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Interactions Of Carbon Nanotubes With Human Lung Epithelial Cells In Vitro, Assessed By Raman Spectroscopy, Peter Knief
Interactions Of Carbon Nanotubes With Human Lung Epithelial Cells In Vitro, Assessed By Raman Spectroscopy, Peter Knief
Doctoral
Current methods for the evaluation of cellular interactions with nanoparticles are non-specific, relatively slow and invasive to the cell. Raman spectroscopy is a non invasive technique whose potential in the biosciences has already been demonstrated and has been used in the investigation of cell interactions with various external agents. The main focus of this study is to employ Raman spectroscopy to investigate the interaction of A549 human lung cells with single walled carbon nanotubes. · Carbon nanotubes have attracted considerable interest not only for their outstanding physical and electronic properties, promising a potentially vast number of applications, but also for …
Toxicity Assessment Of Single-Walled Carbon Nanotubes, Eva Herzog
Toxicity Assessment Of Single-Walled Carbon Nanotubes, Eva Herzog
Doctoral
The objective of this study was to investigate the potential adverse health effects of occupational exposure to SWCNT dust using various in vitro approaches. Lung epithelium (represented by A549 and NHBE cells) was chosen as target cell model and exposed to minimally processed particle samples under submerse conditions and effects were compared to that of carbon black and crocidolite asbestos exposure. Cytotoxicity studies indicated low acute cytotoxicity of SWCNT. Morphological changes included decreases in microvilli and increased numbers of surfactant storing lamellar bodies and changes in cytoskeleton. Due to interactions of SWCNT and toxicity indicator dyes, the clonogenic assay was …