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Full-Text Articles in Physics
Live Cell Biomass Tracking For Basic, Translational, And Clinical Research, Graeme Murray
Live Cell Biomass Tracking For Basic, Translational, And Clinical Research, Graeme Murray
Theses and Dissertations
Single cell mass is tightly regulated throughout generations and the cell cycle, making it an important marker of cell health. Abnormal changes in cell size can be the first indication of dysfunction in response to environmental stimuli such as cytotoxic drugs. Described here is the further development of high-speed live cell interferometry (HSLCI) to concurrently measure the changes in single cell mass of thousands of cells over time. Critically, the high-throughput nature of HSLCI provides realistic pictures of tumor heterogeneity. This throughput enabled HSLCI to correctly predict in vivo carboplatin sensitivity of three triple negative breast cancer patient derived xenografts, …
Zernike Piston Statistics In Turbulent Multi-Aperture Optical Systems, Joshua J. Garretson
Zernike Piston Statistics In Turbulent Multi-Aperture Optical Systems, Joshua J. Garretson
Theses and Dissertations
There is currently a lack of research into how the atmosphere effects Zernike piston. This Zernike piston is a coefficient related to the average phase delay of a wave. Usually Zernike piston can be ignored over a single aperture because it is merely a delay added to the entire wavefront. For multi-aperture interferometers though piston cannot be ignored. The statistics of Zernike piston could supplement and improve atmospheric monitoring, adaptive optics, stellar interferometers, and fringe tracking. This research will focus on developing a statistical model for Zernike piston introduced by atmospheric turbulence.
Quantitative Analysis And Process Of High Speed Live Cell Interferometry Measurements, Daniel Guest
Quantitative Analysis And Process Of High Speed Live Cell Interferometry Measurements, Daniel Guest
Theses and Dissertations
The application of auto focus, using an optical beam deflection technique, to existing live cell interferometry measurements was developed and examined. The benefit to relevant experiments, currently being performed, is shown as well as its performance across various magnifications. Enough information is given so that the system can be reproduced to fit any end users needs.
Measurement Of Plasma Density In A Gas-Filled Ionizing Laser Focus, Nathan Edward Heilmann
Measurement Of Plasma Density In A Gas-Filled Ionizing Laser Focus, Nathan Edward Heilmann
Theses and Dissertations
We use an interferometric method for measuring the plasma density in a laser-induced plasma as a function of time. Any changes in the density within 5 ns of generation is due plasma expansion and not recombination. The analytic solution for plasma expansion derived for ultracold Neutral Plasmas describes the expansion of our laser produced Neon plasma of densities up to approximately 40 Torr. A model for the utlracold neutral plasmas, in comparison with measurements of our plasmas, can be used to extract an electron temperature. Currently our plasmas have shown to have an electron temperature of approximately 44 eV.
Development Of A Strontium-87 Ion Interferometer, Christopher Joseph Erickson
Development Of A Strontium-87 Ion Interferometer, Christopher Joseph Erickson
Theses and Dissertations
I present the construction of a low-velocity intense source (LVIS) of laser-cooled neutral strontium using permanent ring magnets. The LVIS consists of a magneto-optical trap from which cold strontium is extracted in a well-collimated beam. I also present the development and implementation of a full suite of low-noise, high-bandwidth laser control electronics including a microcontroller unit. This microcontroller remotely controls and monitors the current driver, temperature controller, and PID lock circuit for each diode laser simultaneously. The current driver output is accurate to within 2 micro-amps and repeatable to with a few nano-amps. The noise spectral density of the current …
Tunable Optical Delay In Doppler-Broadened Cesium Vapor, Monte D. Anderson
Tunable Optical Delay In Doppler-Broadened Cesium Vapor, Monte D. Anderson
Theses and Dissertations
Variable-delay tunable optical delay line or optical buffers are critical for the development of all-optical networks components as well as interferometry and analytic instruments. Recent research on slow light may hold the key for the development of the first practical tunable optical delay device. In this research the linear dispersion delay effects in an alkali vapor. The hyperfine relaxation observations present insight into the complex bleach wave dynamics during a high-intensity pulsed pump in DPAL systems.
Oh Megamasers In Merging Galaxies: A Multi-Frequency Study Of Iizw096, Kirstin Marie Cooprider
Oh Megamasers In Merging Galaxies: A Multi-Frequency Study Of Iizw096, Kirstin Marie Cooprider
Theses and Dissertations
OH Megamasers (OHMs) generally appear in luminous infrared regions i.e. merging galaxies. In this study we assume that OHMs may not be represented by their association with star formation solely, because of the possibility of a compact AGN source in the merging galaxies. In fact, previously classified starburst galaxies where OHMs are found are now optically observed as AGN. OHMs may also serve as a reasonable criterion for the evolutionary stage of the merger. This project focuses on observations from a multi-frequency analysis of merging regions with known OHMs. Optically, Hα and BVRI filters provided an environmental perspective of the …
Measuring Dispersion In Laser Cavity Mirrors Using White-Light Interferometry, Allison S. Goodspeed
Measuring Dispersion In Laser Cavity Mirrors Using White-Light Interferometry, Allison S. Goodspeed
Theses and Dissertations
Terahertz radiation is an emerging field that has far reaching applications. There is a need for portable and affordable terahertz sources that may be used for detection of structural weaknesses in aerospace composites. One possibility for terahertz generation is a femtosecond Cr:LiSAF laser. However, controlling intracavity dispersion is necessary in order to get the ultrashort pulses needed to generate terahertz radiation. This research measures dispersion of the chirped femtosecond intracavity mirrors by employing white-light interferometry and explains the theory behind the curve-fitting process used to calculate dispersion. To compensate for the narrow reflectivity band of the mirrors, a CaF2 …
Shockwave Interactions With Argon Glow Discharges, Nicholas S. Siefert
Shockwave Interactions With Argon Glow Discharges, Nicholas S. Siefert
Theses and Dissertations
The purpose of this research was study shock wave interactions with argon glow discharges. Specifically, this thesis sought to answer whether it is possible to compress nonequilibrium electrons at the shock wave. The results in the thesis found that both equilibrium and nonequilibrium electrons could be compressed at the shock front. The double layer at the shock front, normalized by electron temperature, matched the calculated values for the double layer within a factor or two in all cases. The results also demonstrate that excited metastable states can be compressed at the shock front, as well. The culmination of this effort …
Characterization Of Spatial And Temporal Anisotropy In Turbulent Mixing Layers Using Optical Techniques, Patrick J. Gardner
Characterization Of Spatial And Temporal Anisotropy In Turbulent Mixing Layers Using Optical Techniques, Patrick J. Gardner
Theses and Dissertations
The optical aberrations induced by mixing layers of dissimilar gases are recorded and analyzed in order to characterize the spatial and temporal properties of the flow. Laser light was propagated through a mixing layer of Helium and Nitrogen gas, having velocities of 8.5 m/sec and 1.5 m/sec, respectively. The light was propagated in a direction perpendicular to the plane of the mixing layer. The mixing layer was evaluated in two experimental regimes: free turbulent mixing, where the mixing layer spreads into the surrounding air; and channel flow, where the mixing layer is confined to a rectangular channel. The optical perturbations …