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Enhanced Nanopore Detection Via Diffusion Gradients And Optical Tweezers, Kyle T. Brady
Enhanced Nanopore Detection Via Diffusion Gradients And Optical Tweezers, Kyle T. Brady
Theses and Dissertations
Nanopore-based resistive pulse sensing represents an important class of single-molecule measurements. It provides information about many molecules of interest (i.e. DNA, proteins, peptides, clusters, polymers, etc.) without the need for labeling. Two experiments that are especially well suited for studying with nanopore sensors are DNA sequencing and DNA-protein force measurements. This thesis will describe progress that has been made in both areas.
DNA sequencing has become an active area of research for stochastic single-molecule sensing, with many researchers striving for the ultimate goal of single-molecule de novo DNA sequencing. One intriguing method towards that goal involves the use of a …