Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Physics
Bubble Nucleation And Cooperativity In Duplex Stretching Of A Helicoidal Dna Model, Pawan Kumar Thapaliya
Bubble Nucleation And Cooperativity In Duplex Stretching Of A Helicoidal Dna Model, Pawan Kumar Thapaliya
Theses and Dissertations
Denaturation of DNA means separation of dsDNA into ssDNA due to the breaking of hydrogen bond by the application of heat or another mechanical method to carry out the processes like translation,transcription, and replication. Single-molecule DNA stretching experiments displayed a force-induced transition at a force of 65pN for long dsDNA molecules. In these experiments, double stranded DNA molecules are stretched by a force applied to opposite ends of the DNA, e.g., in anatomic force microscope or an optical tweezers instrument. Here we study the thermal and force-induced denaturation of the helicoidal DNA bubble-in-the middle sequence by Monte-Carlo simulations technique. We …