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Stable Evolutionary Signal In A Yeast Protein Interaction Network, Stefan Wuchty, Albert-László Barabási, Michael T. Ferdig
Stable Evolutionary Signal In A Yeast Protein Interaction Network, Stefan Wuchty, Albert-László Barabási, Michael T. Ferdig
Albert-László Barabási
Background: The recently emerged protein interaction network paradigm can provide novel and important insights into the innerworkings of a cell. Yet, the heavy burden of both false positive and false negative protein-protein interaction data casts doubt on the broader usefulness of these interaction sets. Approaches focusing on one-protein-at-a-time have been powerfully employed to demonstrate the high degree of conservation of proteins participating in numerous interactions; here, we expand his 'node' focused paradigm to investigate the relative persistence of 'link' based evolutionary signals in a protein interaction network of S. cerevisiae and point out the value of this relatively untapped source …