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Human Disease Classification In The Postgenomic Era: A Complex Systems Approach To Human Pathobiology, Joseph Loscalzo, Isaac Kohane, Albert-László Barabási
Human Disease Classification In The Postgenomic Era: A Complex Systems Approach To Human Pathobiology, Joseph Loscalzo, Isaac Kohane, Albert-László Barabási
Albert-László Barabási
Contemporary classification of human disease derives from observational correlation between pathological analysis and clinical syndromes. Characterizing disease in this way established a nosology that has served clinicians well to the current time, and depends on observational skills and simple laboratory tools to define the syndromic phenotype. Yet, this time-honored diagnostic strategy has significant shortcomings that reflect both a lack of sensitivity in identifying preclinical disease, and a lack of specificity in defining disease unequivocally. In this paper, we focus on the latter limitation, viewing it as a reflection both of the different clinical presentations of many diseases (variable phenotypic expression), …
Human Disease Classification In The Postgenomic Era: A Complex Systems Approach To Human Pathobiology, Joseph Loscalzo, Isaac Kohane, Albert-László Barabási
Human Disease Classification In The Postgenomic Era: A Complex Systems Approach To Human Pathobiology, Joseph Loscalzo, Isaac Kohane, Albert-László Barabási
Albert-László Barabási
Contemporary classification of human disease derives from observational correlation between pathological analysis and clinical syndromes. Characterizing disease in this way established a nosology that has served clinicians well to the current time, and depends on observational skills and simple laboratory tools to define the syndromic phenotype. Yet, this time-honored diagnostic strategy has significant shortcomings that reflect both a lack of sensitivity in identifying preclinical disease, and a lack of specificity in defining disease unequivocally. In this paper, we focus on the latter limitation, viewing it as a reflection both of the different clinical presentations of many diseases (variable phenotypic expression), …