Physics Commons^™

Producing And Measuring Oscillatory Shear In A Novel Microfluidic Chip, Sanaz Lordfard, Daniel Lorusso, Tamie L. Poepping, Hristo N Nikolov, Kayla Soon, Stephen Sims, Jeffrey Dixon, David Holdsworth

Undergraduate Student Research Internships Conference

Purpose: To demonstrate the effectiveness of a novel microfluidic device mimicking oscillatory blood flow, allowing cell biologists to examine how endothelial cells respond to a range of oscillatory shear stress levels.

Methods: The microfluidic chip consists of a circular-shaped reservoir, leading to a rectangular channel that is examined under a microscope. The plunger is connected to a speaker system and oscilloscope, allowing the plunger to apply a range of frequencies (5-60Hz) and voltages (5-10 V, leading to a variety in oscillation amplitudes) to the reservoir region. 1.1 um fluorescent particles diluted in distilled water were used for tracking. Processing was …

Polymer Translocation Through A Nanopore: Controlling Capture Conformations Using An Electrical Force, Matthew D. Wei

Undergraduate Student Research Internships Conference

Solid-state nanopore sensors remain a promising solution to the rising global demand for genome sequencing. These single-molecule sensing technologies require single-file translocation for high resolution and accurate detection. This study uses molecular dynamics-lattice Boltzmann simulations of the capture of a single polymer chain under pressure-driven hydrodynamic flow to investigate a method of increasing the single-file capture and translocation rate. By using a model force of two oppositely electrically charged rings, single-file capture in hydrodynamic flow can be amplified from about 45% to 51.5%. This paper found that the optimal values of force location, force strength, and system pressure/flow velocity are …

Travelling Wave Solutions On A Cylindrical Geometry, Karnav R. Raval

Undergraduate Student Research Internships Conference

Fluid equations are generally quite difficult and computationally-expensive to solve. However, if one is primarily interested in how the surface of the fluid deforms, we can re-formulate the governing equations purely in terms of free surface variables. Reformulating equations in such a way drastically cuts down on computational cost, and may be useful in areas such as modelling blood flow. Here, we study one such free-boundary formulation on a cylindrical geometry.

Numerical Modelling Of A Novel 3d T-Junction Microfluidic Droplet Generator, Andrew G.H. Roberts

Undergraduate Student Research Internships Conference

No abstract provided.