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Full-Text Articles in Physics

Modeling Residence Time Distribution Of Chromatographic Perfusion Resin For Large Biopharmaceutical Molecules: A Computational Fluid Dynamic Study, Kevin Vehar Dec 2020

Modeling Residence Time Distribution Of Chromatographic Perfusion Resin For Large Biopharmaceutical Molecules: A Computational Fluid Dynamic Study, Kevin Vehar

KGI Theses and Dissertations

The need for production processes of large biotherapeutic particles, such as virus-based particles and extracellular vesicles, has risen due to increased demand in the development of vaccinations, gene therapies, and cancer treatments. Liquid chromatography plays a significant role in the purification process and is routinely used with therapeutic protein production. However, performance with larger macromolecules is often inconsistent, and parameter estimation for process development can be extremely time- and resource-intensive. This thesis aimed to utilize advances in computational fluid dynamic (CFD) modeling to generate a first-principle model of the chromatographic process while minimizing model parameter estimation's physical resource demand. Specifically, …


A Study Of The Design Of Adaptive Camber Winglets, Justin J. Rosescu Jun 2020

A Study Of The Design Of Adaptive Camber Winglets, Justin J. Rosescu

Master's Theses

A numerical study was conducted to determine the effect of changing the camber of a winglet on the efficiency of a wing in two distinct flight conditions. Camber was altered via a simple plain flap deflection in the winglet, which produced a constant camber change over the winglet span. Hinge points were located at 20%, 50% and 80% of the chord and the trailing edge was deflected between -5° and +5°. Analysis was performed using a combination of three-dimensional vortex lattice method and two-dimensional panel method to obtain aerodynamic forces for the entire wing, based on different winglet camber configurations. …