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Label-Free Raman Imaging To Monitor Breast Tumor Signatures, John Ciubuc
Label-Free Raman Imaging To Monitor Breast Tumor Signatures, John Ciubuc
Open Access Theses & Dissertations
Methods built on Raman spectroscopy have shown major potential in describing and discriminating between malignant and benign specimens. Accurate, real-time medical diagnosis benefits in substantial improvements through this vibrational optical method. Not only is acquisition of data possible in milliseconds and analysis in minutes, Raman allows concurrent detection and monitoring of all biological components. Besides validating a significant Raman signature distinction between non-tumorigenic (MCF-10A) and tumorigenic (MCF-7) breast epithelial cells, this study reveals a label-free method to assess overexpression of epidermal growth factor receptors (EGFR) in tumor cells. EGFR overexpression sires Raman features associated with phosphorylated threonine and serine, and …
Bragg Gratings In Polarization Maintaining Optical Fiber As Three Dimensional Strain Sensor, Joel Quintana
Bragg Gratings In Polarization Maintaining Optical Fiber As Three Dimensional Strain Sensor, Joel Quintana
Open Access Theses & Dissertations
Fiber-Bragg Gratings (FBG) for Structural Health Monitoring (SHM) have been studied extensively as they offer electrically passive operation, electromagnetic interference (EMI) immunity, high sensitivity and multiplexing as compared to conventional electric strain sensors. FBG sensors written within polarization maintaining (PM) optical fiber offer ad- ditional dimensions of strain measurement, greatly reducing the number of sensors needed to properly monitor a structure. This reduction however, adds complexity to the dis- crimination of the sensorâ??s optical response to its corresponding applied strains. This Dissertation defines the set of algorithms needed to measure planar strain using PM-FBGs exclusively. It defines the minimum number …