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Articles 91 - 120 of 933
Full-Text Articles in Environmental Health and Protection
Developing A Miniature Smart Boat For Marine Research, Michael Isaac Eirinberg
Developing A Miniature Smart Boat For Marine Research, Michael Isaac Eirinberg
Computer Engineering
This project examines the development of a smart boat which could serve as a possible marine research apparatus. The smart boat consists of a miniature vessel containing a low-cost microcontroller to live stream a camera feed, GPS telemetry, and compass data through its own WiFi access point. The smart boat also has the potential for autonomous navigation. My project captivated the interest of several members of California Polytechnic State University, San Luis Obispo’s (Cal Poly SLO) Marine Science Department faculty, who proposed a variety of fascinating and valuable smart boat applications.
Big Business, Small Plastic, Hannah Johnson
Big Business, Small Plastic, Hannah Johnson
Senior Honors Projects
No abstract provided.
Changes In Western U.S. Streamflow Extremes Under Climate Change, Rama Bedri
Changes In Western U.S. Streamflow Extremes Under Climate Change, Rama Bedri
Student Scholar Symposium Abstracts and Posters
We are analyzing streamflow extremes in Western U.S. rivers due to climate change. Global warming causes natural disasters to reach extreme points and affects river volumes, snowfall, and precipitation amounts. We analyze the data for 17 stations in the Colorado River Basin, whose rivers provide Southern California’s drinking water supply. Disruptions in streamflow due to climate change affect the region’s water availability and make it difficult to predict future trends. We compared historical streamflow data to eight possible climate scenarios. The different scenarios are Warm Dry, Cool Wet, Average, and Other at emission levels of RCP 4.5 and 8.5. First, …
Identifying Associations Between Human-Environmental Factors And Water Quality Trends Observed At Perennial Headwater Streams Of The San Bernardino National Forest, California, Anna Frey
Electronic Theses, Projects, and Dissertations
Anthropogenic factors related to landscape activities, infrastructure, and alterations, coupled with severe climatic fluctuations (i.e., droughts and extreme hydrological events) are increasingly impairing the quality of surface water resources across multiple geographic scales, warranting the need for comprehensive investigations of the cumulative effects of human-environmental stressors at multiple scales within a watershed. This study assessed three perennial headwater streams of the San Bernardino National Forest, California. The streams were tested for one year from October 2019 to September 2020 for conductivity, dissolved oxygen (DO), pH, turbidity, temperature, ammonium (NH4+), nitrate (NO3-), total coliform (TC), Escherichia coli …
The Effectiveness Of Best Management Practices Implemented At Lake Gregory, Crestline, Ca, Devin Darrow
The Effectiveness Of Best Management Practices Implemented At Lake Gregory, Crestline, Ca, Devin Darrow
Electronic Theses, Projects, and Dissertations
Water quality deterioration of recreational surface waters from excess pollution inputs is a significant concern for the health of the public and aquatic ecosystem. This study will examine the effectiveness of Best Management Practices (BMPs) in reducing pollution inputs into Lake Gregory, Crestline, CA. The effectiveness of the BMPs was examined by testing for water quality parameters including dissolved oxygen, temperature, pH, conductivity, turbidity, nitrate (NO3-), ammonium (NH4+), total coliform, and Escherichia coli on weekly to bi-weekly basis for a period of 1 year. A statistical analysis involving descriptive statistics, Pearson’s correlation, the Efficient Ratios (ER) and Percent Removal Rates …
Identification And Analysis Of The Contribution Of Various Sources Of Total Dissolved Solids (Tds) In Lake Elsinore Potable Water And Wastewater, Lenai Hunter
Electronic Theses, Projects, and Dissertations
Total Dissolved Solids (TDS) are primarily inorganic salts that can pass through a 2-micron (or smaller) filter and, when found in high concentrations, can cause adverse effects on aquatic organisms and the surrounding environment. The agency servicing Lake Elsinore and surrounding areas is the Elsinore Valley Municipal Water District (EVMWD). EVMWD’s wastewater treatment facilities are not equipped to remove TDS from the wastewater. Therefore, the influent TDS values are often similar to the final treated effluent recycled water TDS values. EVMWD has permit limits at the wastewater treatment plants relating to TDS, and due to the higher influent TDS concentrations …
Floating Treatment Wetlands For Brackish Waters: Plant Selection And Nutrient Uptake Potential., Andrea Landaverde
Floating Treatment Wetlands For Brackish Waters: Plant Selection And Nutrient Uptake Potential., Andrea Landaverde
All Theses
Brackish water bodies in coastal regions provide critical ecosystem services that support human and environmental health. Anthropogenic activities such as agricultural and industrial activities, construction, urban settlements, and tourism contribute to increased inputs of nitrogen (N) and phosphorus (P) in brackish coastal ecosystems. Excess nutrients can lead to impaired water quality and affect marine organisms. Floating treatment wetlands (FTWs) are a vegetated-base technology used to remove contaminants from water column, that has been mainly studied and applied in freshwater systems. Application of FTWs in brackish systems requires further investigation, as high salinity in brackish waters could result in toxicity to …
Safe Water For All: A Multi-Modal Approach To North Alabama's Water Resources, Elijah Walker
Safe Water For All: A Multi-Modal Approach To North Alabama's Water Resources, Elijah Walker
Theses
Environmental degradation is a destructive force produced by the human disturbance of pollution. It is a phenomenon that gradually evolves landscapes over time resulting in irreversible outcomes. Environmental degradation physically affects spaces’ resources, objects, and inhabiting humans. This study observes the impacts of pollution beyond physical boundaries and how it affects human identity/sense of place through the utilization of geographic information systems. Specifically, it examines cultural identity developed through human experiences and connections to landscapes containing water resources. Following, pollution contaminates water resources disrupting experiences and connections thus causing the cultural identity to disappear. The case study applied to this …
Nebraska Water Center Annual Report 2022, Nebraska Water Center, Daugherty Water For Food Global Institute
Nebraska Water Center Annual Report 2022, Nebraska Water Center, Daugherty Water For Food Global Institute
Nebraska Water Center: Administrative Materials
CONTENTS
Overview: The Nebraska Water Center (https://watercenter.unl.edu)
Fast Facts: NWC 2022 Snapshot
Our Work
Water Sciences Lab Sees Rapid Growth in 2022 (https://watercenter.unl.edu/water-sciences-laboratory2)
WSL is Key to AltEn Contamination Monitoring (https://go.unl.edu/mead)
Know Your Well Project Enters Third Phase (https://knowyourwell.unl.edu)
Computer Science Students Build New Platform for Know Your Well Data Collection
Water Sciences Laboratory Helps Nebraska Tackle Nitrate (https://watercenter.unl.edu/water-sciences-laboratory2)
Nebraska Rural Poll Includes Water Quality Questions (https://ruralpoll.unl.edu and https://go.unl.edu/nitrate_strategy)
NWC Holds Platte River Basin Conference (https://watercenter.unl.edu/2022-nebraska-water-conference)
Spring Seminar Series (https://watercenter.unl.edu/spring-seminar-series)
Water Center Undergoes Five-Year …
Carli Creek Regional Water Quality Project: Assessing Water Quality Improvement At An Urban Stormwater Constructed Wetland, Christopher L. Desiderati
Carli Creek Regional Water Quality Project: Assessing Water Quality Improvement At An Urban Stormwater Constructed Wetland, Christopher L. Desiderati
Environmental Science and Management Professional Master's Project Reports
Stormwater management is an ongoing challenge in the United States and the world at-large. As state and municipal agencies grapple with conflicting interests like encouraging land development, complying with permits to control stormwater discharges, “urban stream syndrome” effects, and charges to steward natural resources for the long-term, some agencies may turn to constructed wetlands (CWs) as aesthetically pleasing and functional natural analogs for attenuating pollution delivered by stormwater runoff to rivers and streams. Constructed wetlands retain pollutants via common physical, physicochemical, and biological principles such as settling, adsorption, or plant and algae uptake. The efficacy of constructed wetlands for pollutant …
Largemouth Bass In The Upper Mississippi River: An Evaluation Of Management Strategies And Understanding Potential Factors Influencing Dynamic Rate Functions, Kylie Beth Sterling
Largemouth Bass In The Upper Mississippi River: An Evaluation Of Management Strategies And Understanding Potential Factors Influencing Dynamic Rate Functions, Kylie Beth Sterling
Graduate Theses/Dissertations
The Upper Mississippi River (UMR) supports ecologically and economically important commercial and recreational fisheries. One recreational fishery in the UMR is the Largemouth Bass fishery. Recreational fisheries can be effectively managed using information on population dynamics, though little is known about Largemouth Bass population dynamics in large river ecosystems. Therefore, the objectives of this study were to 1) evaluate recruitment, growth, and mortality of three Largemouth Bass populations in the UMR, specifically within Pools 4, 8, and 13, and 2) to use those estimates of recruitment, growth and mortality to inform exploitation models to evaluate best management practices for each …
Review Of Analytical Techniques For Arsenic Detection And Determination In Drinking Water, Abhijnan Bhat, Tony O'Hara, Furong Tian, Baljit Singh Dr.
Review Of Analytical Techniques For Arsenic Detection And Determination In Drinking Water, Abhijnan Bhat, Tony O'Hara, Furong Tian, Baljit Singh Dr.
Articles
Arsenic occurs in the natural environment in four oxidation states: As(V), As(III), As(0) and As(−III). The behavior of arsenic species changes depending on the biotic or abiotic conditions in water. In groundwater, arsenic is predominantly present as As(III) and As(V), with a minor amount of methyl and dimethyl arsenic compounds being reported. Global intake of As(III) and As(V) via drinking water and food has dramatically increased in recent years. The commonly used term inorganic arsenic includes both As(III) and As(V) species and constitutes the highest toxicological risk associated with arsenic in water compared to the organic arsenic species. Inorganic arsenic …
Zebra Mussel Length-Weight Relationships Across Various Substrate Types In Lake Bemidji, Mitch Kehne
Zebra Mussel Length-Weight Relationships Across Various Substrate Types In Lake Bemidji, Mitch Kehne
Journal of Earth and Life Science
As of November 2021, zebra mussels were confirmed in 270 Minnesotan lakes with another 232 lakes listed as infested due to their connection or proximity to where zebra mussels have been found. With lack of effective treatments to impede their spread, zebra mussels continue to colonize new areas causing ecological as well as economic harm. The goal of this study was to establish a length-weight relationship for the zebra mussel population in Lake Bemidji using shell length (SL) and wet weight (WW), as well as to assess substrate type and log transformed shell length as predictors of log transformed zebra …
Combined Effects Of Temperature And Heavy Metals On The Performance Of The Giant Salmonfly., James Frakes, Amanda Andreas, Benjamin P. Colman, Aurthur Woods
Combined Effects Of Temperature And Heavy Metals On The Performance Of The Giant Salmonfly., James Frakes, Amanda Andreas, Benjamin P. Colman, Aurthur Woods
Graduate Student Theses, Dissertations, & Professional Papers
In many freshwater ecosystems, communities of aquatic insects are facing the combined stresses of warmer waters due to climate change and increased exposure to heavy metal toxicants. Although each stressor may threaten aquatic insects independently, they also likely interact in important ways to affect insect physiology and performance. Here we investigate this potential interaction using two populations of aquatic nymphs of the giant salmonfly, Pteronarcys californica, collected from adjacent rivers in Montana: naïve individuals from Rock Creek, a relatively pristine stream, and individuals from the Upper Clark Fork River, which has a history of heavy metal pollution and higher …
Feasibility Of Development Of Flood Resiliency Clearinghouse Program, Commonwealth Center For Recurrent Flooding Resiliency, Mujde Erten-Unal, Carol Considine, Mark W. Luckenbach, Elizabeth Armistead Andrews
Feasibility Of Development Of Flood Resiliency Clearinghouse Program, Commonwealth Center For Recurrent Flooding Resiliency, Mujde Erten-Unal, Carol Considine, Mark W. Luckenbach, Elizabeth Armistead Andrews
Commonwealth Center for Recurrent Flooding Resiliency (CCRFR): Reports
[Introduction]
House Bill 2187i, introduced by Delegate Keith Hodges in the 2021 session of the Virginia General Assembly, directed the Commonwealth Center for Recurrent Flooding Resiliency (CCRFR), a partnership between Old Dominion University, the Virginia Institute of Marine Science (VIMS) and the William & Mary Law School’s Virginia Coastal Policy Center (VCPC) established by Virginia Chapter 440 of the 2016 Acts of Assembly (HB 903), to evaluate the development of a Flood Resiliency Clearinghouse Program (henceforth Clearinghouse). The bill stipulated that the Center should work with the Department of Conservation and Recreation (DCR) to evaluate solutions that manage …
An Assessment Of Nutrient Improvement In Surface Water Due To The Conversion Of Onsite Sewage Treatment And Disposal Systems To Sewerage, Jenelle A. Mohammed
An Assessment Of Nutrient Improvement In Surface Water Due To The Conversion Of Onsite Sewage Treatment And Disposal Systems To Sewerage, Jenelle A. Mohammed
USF Tampa Graduate Theses and Dissertations
Florida represents approximately 12% of all onsite sewage treatment and disposal systems (OSTDS) in the United States. Properly designed, constructed and maintained OSTDS are effective eco- friendly alternatives for the treatment of domestic wastewater from households not serviced by public sewer systems. However, conventional OSTDS are not designed to effectively remove nitrogen. If installed and improperly used, they may contribute other pollutants. OSTDS have also been linked to degraded water quality in some regions. However, it has been difficult to quantify OSTDS impacts on water quality because of various confounding factors such as point and non-point sources of nutrient input. …
Taking The Waste Out Of Wastewater: Evaluation And Implementation Of Sustainability Measures At Base Aérea N.°5’S Wastewater Treatment Plant, Abigail Monahan
Taking The Waste Out Of Wastewater: Evaluation And Implementation Of Sustainability Measures At Base Aérea N.°5’S Wastewater Treatment Plant, Abigail Monahan
Independent Study Project (ISP) Collection
Wastewater treatment is a critical process by which the concentration of pollutants in wastewater are reduced to minimize the resulting effluent’s impact on human health and the environment. Base Aérea N.°5, an airbase located in Monte Real, Portugal, is striving to enhance their wastewater treatment methods to decrease the impact of the treated effluent on the environment. They can reduce the effluent’s impact by implementing more advanced wastewater treatment to decrease the concentration of micropollutants and pathogens in the effluent, and they can reuse the treated effluent to decrease the volume of freshwater they extract. This work seeks to evaluate …
Do Environmental Toxins Predict Violent Crimes?, Tyler Stahl
Do Environmental Toxins Predict Violent Crimes?, Tyler Stahl
Symposium of Student Scholars
Do chemical pollutants that persistent in the environment and bioaccumulate in the body affect human health and behavior? Could these Persistent, Bioaccumulative, and Toxic (PBT) chemicals play a role in the cause of violent crimes due to deterioration of mental and cognitive functions? In the past, Mercury, a PBT chemical, has been shown in salmon to be associated with aggression. Could similar aggression occur in humans exposed to mercury through a toxic spill? Two sources of data are utilized in this analysis. The Environmental Protection Agency’s (EPA) Annual Toxic Release Inventory publishes data on toxic releases into the environment and …
Spatial Analysis Of Landscape Characteristics, Anthropogenic Factors, And Seasonality Effects On Water Quality In Portland, Oregon, Katherine Gelsey, Daniel Ramirez
Spatial Analysis Of Landscape Characteristics, Anthropogenic Factors, And Seasonality Effects On Water Quality In Portland, Oregon, Katherine Gelsey, Daniel Ramirez
REU Final Reports
Urban areas often struggle with deteriorated water quality as a result of complex interactions between landscape factors such as land cover, use, and management as well as climatic variables such as weather, precipitation, and atmospheric conditions. Green stormwater infrastructure (GSI) has been introduced as a strategy to reintroduce pre-development hydrological conditions in cities, but questions remain as to how GSI interacts with other landscape factors to affect water quality. We conducted a statistical analysis of six relevant water quality indicators in 131 water quality stations in four watersheds around Portland, Oregon using data from 2015 to 2021. Indiscriminate of station …
Impacts Of Oil And Gas Wastes On Landfill Leachate, Sewage Treatment Plants, And The Environment, Lauren Badertscher
Impacts Of Oil And Gas Wastes On Landfill Leachate, Sewage Treatment Plants, And The Environment, Lauren Badertscher
Electronic Theses and Dissertations
Between January 2011 and March 2021 oil and gas wells in Pennsylvania produced
305,637,795 barrels of liquid waste and 6,992,957 tons of solid waste with the majority from
Marcellus Shale unconventional wells. This waste is not considered hazardous and over 89% of
the solid waste generated by unconventional and conventional oil and gas extraction has been
disposed of in landfills over the past decade. This study examined trends in the quantity of waste
produced and methods of disposal. Landfills accepting this waste were identified and their
general method of leachate treatment, using onsite facilities or offsite at wastewater treatment
plants, …
Spatial Variability Of Nonpoint Source Yields In Ozark Highlands Watersheds Under Historical And Recent Land Use Conditions, Tyler J. Pursley
Spatial Variability Of Nonpoint Source Yields In Ozark Highlands Watersheds Under Historical And Recent Land Use Conditions, Tyler J. Pursley
Graduate Theses/Dissertations
Many of the environmental problems facing communities today stem from historical as well as present land use disturbances related to agriculture, urbanization, and resource extraction. It is important to evaluate a range of land use and soil effects on nonpoint source (NPS) pollution to fully understand land use-water quality relationships. The Ozark Highlands region has undergone significant phases of land use change throughout its settlement history and is actively developing today (2020). This study used nonpoint nitrogen (TN), phosphorus (TP), and sediment (TSS) yields predicted by the US EPA’s Spreadsheet Tool for Estimating Pollutant Loads (STEPL) model to evaluate human …
Mapping Plastic Pollution In The Amite Watershed, Louisiana, Gourav Divan
Mapping Plastic Pollution In The Amite Watershed, Louisiana, Gourav Divan
LSU Master's Theses
Microplastics have quickly emerged as a concerning pollutant in both freshwater and marine environments. Their recent discovery means that their impacts are still being studied, however, it is important to continuously monitor their concentrations. An important conduit of plastic pollution to marine environments are rivers and streams. Previous models have estimated the transport of plastics from land to sea in many parts of the world. Most of these models, however, have been conducted at coarse spatial resolutions that make it difficult to establish tractable management programs to minimize this impact. Here, a previously existing model was applied to model for …
Re: Annual Quality Assurance Project Plan Updates For Butte Reduction Works Smelter Area Mine Waste Remediation And Contaminated Groundwater Hydraulic Control Site, Josh Bryson
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Presence Of Severe Acute Respiratory Syndrome Coronavirus 2 In Urban Streams Receiving Sewer Overflow, Louisville, Kentucky, Usa., Cullen Hunter
Presence Of Severe Acute Respiratory Syndrome Coronavirus 2 In Urban Streams Receiving Sewer Overflow, Louisville, Kentucky, Usa., Cullen Hunter
Electronic Theses and Dissertations
Pathogens may enter surface waters as they are shed in human feces and potentially delivered to surface waters via sewer overflows, particularly in the eastern United States. This study examined of the presence of fecal indicators in two forks of Beargrass Creek in Louisville, Kentucky. Surface water grab samples (N=30), sediment samples, water quality, and a paired wastewater surveillance study were analyzed. SARS-CoV-2 was detected in a single stream sample despite ubiquitous presence of the virus within the area in wastewater and consistent evidence of a human fecal indicator. These findings demonstrate the need for more green and gray infrastructure …
Investigative Study Of Microalgal And Electrochemical Wastewater Treatment Systems And Modeling Of The Wafer-Enhanced Electrodeionization Using Supervised Learning, Humeyra Betul Ulusoy Erol
Investigative Study Of Microalgal And Electrochemical Wastewater Treatment Systems And Modeling Of The Wafer-Enhanced Electrodeionization Using Supervised Learning, Humeyra Betul Ulusoy Erol
Graduate Theses and Dissertations
Wastewater has a serious impact on environment and public health due to its high concentration of nutrients and toxic contaminants. Without proper treatment, excess nutrients discharged in wastewater can cause a damage to the ecosystem such as undesirable pH shifts, cyanotoxin production, and low dissolved oxygen concentrations.
Main objectives of this dissertation work were to investigate i) the biofuel potential of P. cruentum when grown in swine wastewater, ii) the influence of four most commonly used ion exchange resins on the system efficiency and selectivity for the removal of sodium, calcium, and magnesium ions, and iii) the modeling of wafer-enhanced …
Moving Beyond ‘More Crop Per Drop’: Insights From Two Decades Of Research On Agricultural Water Productivity, Meredith Giordano, Susanne M. Scheierling, David O. Tréguer, Hugh Turral, Peter G. Mccornick
Moving Beyond ‘More Crop Per Drop’: Insights From Two Decades Of Research On Agricultural Water Productivity, Meredith Giordano, Susanne M. Scheierling, David O. Tréguer, Hugh Turral, Peter G. Mccornick
Daugherty Water for Food Global Institute: Faculty Publications
Concern over increasing water scarcity has led to the introduction of the concept of agricultural water productivity and an emphasis on interventions to achieve ‘more crop per drop’. Yet, a strong debate continues on how the concept is to be defined and used. Drawing largely from the irrigation literature, the origins of the concept and its methodological developments are reviewed, and its use in applied work over two decades is discussed. Based on this analysis of conceptual and applied research, key insights into the concept’s contributions and limitations are presented, as well as opportunities for further refinements.
Nebraska Water Center Annual Report 2019-2020
Nebraska Water Center Annual Report 2019-2020
Nebraska Water Center: Administrative Materials
Contents
Introduction: Foreword • Director’s Letter • Nebraska Water Center (NWC) Overview and Timeline • In Memoriam: Kyle Hoagland
Research • Water Sciences Laboratory • Nebraska Vadose Zone Program • Ogallala Water Coordinated Agriculture Project • Water for Agriculture Project • Greeley Award • U.S. Geological Survey 104b Projects
Extension & Outreach: NWC Events • Nebraska Nitrate Initiative • Bazile Groundwater Management Area • Water and Integrated Crops Hub • Water Faculty Directory • State Legislative Funding • Water Resources Advisory Panel
Teaching: Know Your Well • Sorab Panday Spotlight • NWC Postdoc Profiles • NWC Student Intern Profiles • …
Long Term Nutrient And Chlorophyll A Dynamics Across Long Island Sound And Impacts On Dissolved Oxygen Conditions Within The Western Sound (1991-2019), Sherry Perreira
Long Term Nutrient And Chlorophyll A Dynamics Across Long Island Sound And Impacts On Dissolved Oxygen Conditions Within The Western Sound (1991-2019), Sherry Perreira
Dissertations and Theses
Nitrogen overload, eutrophication, and hypoxia have been challenging and persistent water quality problems in Long Island Sound (LIS) over the past decades with major impacts on commercial industries, ecology, and recreational activities in the region. Recognizing these problems, the EPA enforced three phases of the Clean Water Act (CWA) to reduce nitrogen loads in an effort to improve this important estuary. This study examines how nitrogen (NH3, NOx & TDN), chlorophyll a (CHLA), and dissolved oxygen (DO) concentrations changed in LIS over the past 30 years, in response to water quality regulations as well as changes in …
The Quantitative Assessment Of Pond Scum: An Examination Of The Biogeochemistry Of Phosphorus Cycling In The Belgrade Lakes, Abbey M. Sykes
The Quantitative Assessment Of Pond Scum: An Examination Of The Biogeochemistry Of Phosphorus Cycling In The Belgrade Lakes, Abbey M. Sykes
Honors Theses
The internal recycling phosphorus in freshwater lake bottom sediments represents a significant source of hypolimnetic phosphorus (P) release for many of Maine’s lakes. In summer months, Maine lakes often thermally stratify and the lake hypolimnion develops anoxia, leading to a reduction in redox potential at the sediment-water interface. These reducing conditions facilitate the reductive dissolution of ferric iron, and, since phosphorus is often present in freshwater lake sediments as solid FeOOH-PO4 complexes, results in release of soluble phosphorus into the water column. Our current study presents field and laboratory data from sediment fractionation extractions designed to quantify concentrations of …
Exploring The Genetic Variability Of Zebra Mussels Dreisenna Polymoprha, Maxwell Carr
Exploring The Genetic Variability Of Zebra Mussels Dreisenna Polymoprha, Maxwell Carr
Journal of Earth and Life Science
Zebra Mussels Dreisenna polymorpha are one of the most well-known invasive species here in the United States. This species can take over watersheds very quickly, causing damage to both the ecosystem and man-made structures. The basic physical behavior of this species has been well documented, but the invasive North American Zebra Mussel is much more aggressive and therefore causes more damage in the Great Lakes region compared to its native waters. Genetic variation may be playing a very large role in how and why D. polymorpha is causing such large problems for stakeholders in the United States. This review cites …