Data Science Commons^™

Automated Contouring And Planning In Radiation Therapy: What Is 'Clinically Acceptable'?, Hana Baroudi, Kristy K Brock, Wenhua Cao, Xinru Chen, Caroline Chung, Laurence E Court, Mohammad D El Basha, Maguy Farhat, Skylar Gay, Mary P Gronberg, Aashish Chandra Gupta, Soleil Hernandez, Kai Huang, David A Jaffray, Rebecca Lim, Barbara Marquez, Kelly Nealon, Tucker J Netherton, Callistus M Nguyen, Brandon Reber, Dong Joo Rhee, Ramon M Salazar, Mihir D Shanker, Carlos Sjogreen, Mckell Woodland, Jinzhong Yang, Cenji Yu, Yao Zhao

Faculty, Staff and Student Publications

Developers and users of artificial-intelligence-based tools for automatic contouring and treatment planning in radiotherapy are expected to assess clinical acceptability of these tools. However, what is 'clinical acceptability'? Quantitative and qualitative approaches have been used to assess this ill-defined concept, all of which have advantages and disadvantages or limitations. The approach chosen may depend on the goal of the study as well as on available resources. In this paper, we discuss various aspects of 'clinical acceptability' and how they can move us toward a standard for defining clinical acceptability of new autocontouring and planning tools.

Session11: Skip-Gcn : A Framework For Hierarchical Graph Representation Learning, Jackson Cates, Justin Lewis, Randy Hoover, Kyle Caudle

SDSU Data Science Symposium

Recently there has been high demand for the representation learning of graphs. Graphs are a complex data structure that contains both topology and features. There are first several domains for graphs, such as infectious disease contact tracing and social media network communications interactions. The literature describes several methods developed that work to represent nodes in an embedding space, allowing for classical techniques to perform node classification and prediction. One such method is the graph convolutional neural network that aggregates the node neighbor’s features to create the embedding. Another method, Walklets, takes advantage of the topological information stored in a graph …

2d Respiratory Sound Analysis To Detect Lung Abnormalities, Rafia Sharmin Alice, Kc Santosh

SDSU Data Science Symposium

Abstract. In this paper, we analyze deep visual features from 2D data representation(s) of the respiratory sound to detect evidence of lung abnormalities. The primary motivation behind this is that visual cues are more important in decision-making than raw data (lung sound). Early detection and prompt treatments are essential for any future possible respiratory disorders, and respiratory sound is proven to be one of the biomarkers. In contrast to state-of-the-art approaches, we aim at understanding/analyzing visual features using our Convolutional Neural Networks (CNN) tailored Deep Learning Models, where we consider all possible 2D data such as Spectrogram, Mel-frequency Cepstral Coefficients …

Temporal Tensor Factorization For Multidimensional Forecasting, Jackson Cates, Karissa Scipke, Randy Hoover, Kyle Caudle

SDSU Data Science Symposium

In the era of big data, there is a need for forecasting high-dimensional time series that might be incomplete, sparse, and/or nonstationary. The current research aims to solve this problem for two-dimensional data through a combination of temporal matrix factorization (TMF) and low-rank tensor factorization. From this method, we propose an expansion of TMF to two-dimensional data: temporal tensor factorization (TTF). The current research aims to interpolate missing values via low-rank tensor factorization, which produces a latent space of the original multilinear time series. We then can perform forecasting in the latent space. We present experimental results of the proposed …

Emotion Classification Of Indonesian Tweets Using Bidirectional Lstm, Aaron K. Glenn, Phillip M. Lacasse, Bruce A. Cox

Faculty Publications

Emotion classification can be a powerful tool to derive narratives from social media data. Traditional machine learning models that perform emotion classification on Indonesian Twitter data exist but rely on closed-source features. Recurrent neural networks can meet or exceed the performance of state-of-the-art traditional machine learning techniques using exclusively open-source data and models. Specifically, these results show that recurrent neural network variants can produce more than an 8% gain in accuracy in comparison with logistic regression and SVM techniques and a 15% gain over random forest when using FastText embeddings. This research found a statistical significance in the performance of …

Hemoglobin Concentration Impacts Viscoelastic Hemostatic Assays In Icu Admitted Patients, David J Roh, Tiffany R Chang, Aditya Kumar, Devin Burke, Glenda Torres, Katherine Xu, Winni Yang, Azzurra Cottarelli, Ernest Moore, Angela Sauaia, Kirk Hansen, Angela Velazquez, Amelia Boehme, Athina Vrosgou, Shivani Ghoshal, Soojin Park, Sachin Agarwal, Jan Claassen, E Sander Connolly, Gebhard Wagener, Richard O Francis, Eldad Hod

Faculty, Staff and Student Publications

Objectives: Low hemoglobin concentration impairs clinical hemostasis across several diseases. It is unclear whether hemoglobin impacts laboratory functional coagulation assessments. We evaluated the relationship of hemoglobin concentration on viscoelastic hemostatic assays in intracerebral hemorrhage (ICH) and perioperative patients admitted to an ICU.

Design: Observational cohort study and separate in vitro laboratory study.

Setting: Multicenter tertiary referral ICUs.

Patients: Two acute ICH cohorts receiving distinct testing modalities: rotational thromboelastometry (ROTEM) and thromboelastography (TEG), and a third surgical ICU cohort receiving ROTEM were evaluated to assess the generalizability of findings across disease processes and testing platforms. A separate in vitro ROTEM laboratory …

Biological Correlates Of The Effects Of Auricular Point Acupressure On Pain, Chao Hsing Yeh, Nada Lukkahatai, Xinran Huang, Hulin Wu, Hongyu Wang, Jingyu Zhang, Xinyi Sun, Thomas J Smith

Faculty, Staff and Student Publications

BACKGROUND: To identify candidate inflammatory biomarkers for the underlying mechanism of auricular point acupressure (APA) on pain relief and examine the correlations among pain intensity, interference, and inflammatory biomarkers.

DESIGN: This is a secondary data analysis.

METHODS: Data on inflammatory biomarkers collected via blood samples and patient self-reported pain intensity and interference from three pilot studies (chronic low back pain, n = 61; arthralgia related to aromatase inhibitors, n = 20; and chemotherapy-induced neuropathy, n = 15) were integrated and analyzed. This paper reports the results based on within-subject treatment effects (change in scores from pre- to post-APA intervention) for …

Machine Learning And Acute Stroke Imaging, Sunil A Sheth, Luca Giancardo, Marco Colasurdo, Visish M Srinivasan, Arash Niktabe, Peter Kan

Faculty, Staff and Student Publications

BACKGROUND: In recent years, machine learning (ML) has had notable success in providing automated analyses of neuroimaging studies, and its role is likely to increase in the future. Thus, it is paramount for clinicians to understand these approaches, gain facility with interpreting ML results, and learn how to assess algorithm performance.

OBJECTIVE: To provide an overview of ML, present its role in acute stroke imaging, discuss methods to evaluate algorithms, and then provide an assessment of existing approaches.

METHODS: In this review, we give an overview of ML techniques commonly used in medical imaging analysis and methods to evaluate performance. …

Alphaviruses Detected In Mosquitoes In The North-Eastern Regions Of South Africa, 2014 To 2018, Milehna M Guarido, Isabel Fourie, Kgothatso Meno, Adriano Mendes, Megan A Riddin, Caitlin Macintyre, Sontaga Manyana, Todd Johnson, Maarten Schrama, Erin E Gorsich, Basil D Brooke, Antonio Paulo G Almeida, Marietjie Venter

Faculty, Staff and Student Publications

The prevalence and distribution of African alphaviruses such as chikungunya have increased in recent years. Therefore, a better understanding of the local distribution of alphaviruses in vectors across the African continent is important. Here, entomological surveillance was performed from 2014 to 2018 at selected sites in north-eastern parts of South Africa where alphaviruses have been identified during outbreaks in humans and animals in the past. Mosquitoes were collected using a net, CDC-light, and BG-traps. An alphavirus genus-specific nested RT-PCR was used for screening, and positive pools were confirmed by sequencing and phylogenetic analysis. We collected 64,603 mosquitoes from 11 genera, …

Social Impacts Of Robotics On The Labor And Employment Market, Kelvin Espinal

Dissertations, Theses, and Capstone Projects

Robotics have been introduced into the workplace to perform tasks that human beings have traditionally fulfilled. Complementing or substituting human labor with robotics eliminates human involvement in functions attributable to hazardous environments, heavy lifting, toxic substances, and repetitive low-level tasks. On the other hand, they are meant to be more efficient and cost-effective, saving money, time, and labor. However, since the introduction of robotics in the workforce, societal opposition has been towards this branch of technology in fear of losing employment, wages, and purpose.

Previous studies have reported an overarching societal fear that adopting robotics in the workplace and industry …

Analyzing Relationships With Machine Learning, Oscar Ko

Dissertations, Theses, and Capstone Projects

Procedurally, this project aims to take a dataset, analyze it, and offer insights to the audience in an easy-to-digest format. Conceptually, this project will seek to explore questions like: “Do couples that meet through online dating or dating apps have higher or lower quality relationships?”, “Can any features in this dataset help predict how a subject would rate their relationship quality?”, and “What other insights can I derive from using machine learning for exploratory analysis?” The intended audience for this project is anyone interested in romantic relationships or machine learning.

The dataset is from a Stanford University survey, “How Couples …

Revealing The Three-Dimensional Magnetic Texture With Machine Learning Models, Shihua Zhao

Dissertations, Theses, and Capstone Projects

Revealing three-dimensional (3D) magnetic textures with vector field electron tomography (VFET) is essential in studying novel magnetic materials with topologically protected spin textures potentially being used in the next-generation semiconductor industry. In this dissertation, we use machine learning (ML) models to reconstruct 3D magnetic textures from electron holography (EH) data.

We can feed the EH data, a series of two-dimensional (2D) phasemaps, into a neural network (NN) architecture directly or feed the EH data into a conventional VFET and then feed the reconstructed results into a NN. Thus, perceptive NN, either a simple convolutional neural network (CNN) or Unet architecture, …

Skeleton-Based Hand Gesture Recognition Using Data-Level Fusion, Oluwaleke Yusuf

Theses and Dissertations

Hand Gesture Recognition (HGR) is a form of perceptual computing that allows artificial systems to capture and interpret human gestures. HGR has applications in human-machine interaction, virtual reality, augmented reality, and human behavior analysis. The human hand can assume a near-infinite number of poses and orientations to form myriad gestures, thus increasing the difficulty of the HGR task.

The hand skeleton of connected joints effectively describes the hand’s geometric shape and thus contains richer semantic gesture information while eliminating noise from individual differences in physical hand characteristics. The efficacy and computational efficiency of skeleton-based HGR frameworks can be significantly enhanced …

Data Science Transfer Pathways From Associate's To Bachelor's Programs, Benjamin S. Baumer, Nicholas J. Horton

Statistical and Data Sciences: Faculty Publications

A substantial fraction of students who complete their college education at a public university in the United States begin their journey at one of the 935 public 2-year colleges. While the number of 4-year colleges offering bachelor’s degrees in data science continues to increase, data science instruction at many 2-year colleges lags behind. A major impediment is the relative paucity of introductory data science courses that serve multiple student audiences and can easily transfer. In addition, the lack of predefined transfer pathways (or articulation agreements) for data science creates a growing disconnect that leaves students who want to study data …

Determining The Proportionality Of Ischemic Stroke Risk Factors To Age, Elizabeth Hunter, John D. Kelleher

Articles

While age is an important risk factor, there are some disadvantages to including it in a stroke risk model: age can dominate the risk score and lead to over-or under-predictions in some age groups. There is evidence to suggest that some of these disadvantages are due to the non-proportionality of other risk factors with age, eg, risk factors contribute differently to stroke risk based on an individual’s age. In this paper, we present a framework to test if risk factors are proportional with age. We then apply the framework to a set of risk factors using Framingham heart study data …

Synthesize Heterogeneous Biological Knowledge Via Representation Learning For Alzheimer’S Disease Drug Repurposing, Kang-Lin Hsieh, German Plascencia-Villa, Ko-Hong Lin, George Perry, Xiaoqian Jiang, Yejin Kim

Faculty, Staff and Student Publications

Developing drugs for treating Alzheimer's disease has been extremely challenging and costly due to limited knowledge of underlying mechanisms and therapeutic targets. To address the challenge in AD drug development, we developed a multi-task deep learning pipeline that learns biological interactions and AD risk genes, then utilizes multi-level evidence on drug efficacy to identify repurposable drug candidates. Using the embedding derived from the model, we ranked drug candidates based on evidence from post-treatment transcriptomic patterns, efficacy in preclinical models, population-based treatment effects, and clinical trials. We mechanistically validated the top-ranked candidates in neuronal cells, identifying drug combinations with efficacy in …

A Bidirectional Deep Lstm Machine Learning Method For Flight Delay Modelling And Analysis, Desmond B. Bisandu, Irene Moulitsas

National Training Aircraft Symposium (NTAS)

Flight delays can be prevented by providing a reference point from an accurate prediction model because predicting flight delays is a problem with a specific space. Only a few algorithms consider predicted classes' mutual correlation during flight delay classification or prediction modelling tasks. None of these existing methods works for all scenarios. Therefore, the need to investigate the performance of more models in solving the problem of flight delay is vast and rapidly increasing. This paper presents the development and evaluation of LSTM and BiLSTM models by comparing them for a flight delay prediction. The LSTM does the feature extraction …

Integrated Organizational Machine Learning For Aviation Flight Data, Michael J. Pritchard, Paul Thomas, Eric Webb, Jon Martin, Austin Walden

National Training Aircraft Symposium (NTAS)

An increased availability of data and computing power has allowed organizations to apply machine learning techniques to various fleet monitoring activities. Additionally, our ability to acquire aircraft data has increased due to the miniaturization of small form factor computing machines. Aircraft data collection processes contain many data features in the form of multivariate time-series (continuous, discrete, categorical, etc.) which can be used to train machine learning models. Yet, three major challenges still face many flight organizations 1) integration and automation of data collection frameworks, 2) data cleanup and preparation, and 3) embedded machine learning framework. Data cleanup and preparation has …

Integrated Mrna Sequence Optimization Using Deep Learning, Haoran Gong, Jianguo Wen, Ruihan Luo, Yuzhou Feng, Jingjing Guo, Hongguang Fu, Xiaobo Zhou

Faculty, Staff and Student Publications

The coronavirus disease of 2019 pandemic has catalyzed the rapid development of mRNA vaccines, whereas, how to optimize the mRNA sequence of exogenous gene such as severe acute respiratory syndrome coronavirus 2 spike to fit human cells remains a critical challenge. A new algorithm, iDRO (integrated deep-learning-based mRNA optimization), is developed to optimize multiple components of mRNA sequences based on given amino acid sequences of target protein. Considering the biological constraints, we divided iDRO into two steps: open reading frame (ORF) optimization and 5' untranslated region (UTR) and 3'UTR generation. In ORF optimization, BiLSTM-CRF (bidirectional long-short-term memory with conditional random …

Ontologies Applied In Clinical Decision Support System Rules: Systematic Review, Xia Jing, Hua Min, Yang Gong, Paul Biondich, David Robinson, Timothy Law, Christian Nohr, Arild Faxvaag, Lior Rennert, Nina Hubig, Ronald Gimbel

Faculty, Staff and Student Publications

BACKGROUND: Clinical decision support systems (CDSSs) are important for the quality and safety of health care delivery. Although CDSS rules guide CDSS behavior, they are not routinely shared and reused.

OBJECTIVE: Ontologies have the potential to promote the reuse of CDSS rules. Therefore, we systematically screened the literature to elaborate on the current status of ontologies applied in CDSS rules, such as rule management, which uses captured CDSS rule usage data and user feedback data to tailor CDSS services to be more accurate, and maintenance, which updates CDSS rules. Through this systematic literature review, we aim to identify the frontiers …

Wrapper-Based Deep Feature Optimization For Activity Recognition In The Wearable Sensor Networks Of Healthcare Systems, Karam Kumar Sahoo, Raghunath Ghosh, Saurav Mallik, Arup Roy, Pawan Kumar Singh, Zhongming Zhao

Faculty, Staff and Student Publications

The Human Activity Recognition (HAR) problem leverages pattern recognition to classify physical human activities as they are captured by several sensor modalities. Remote monitoring of an individual's activities has gained importance due to the reduction in travel and physical activities during the pandemic. Research on HAR enables one person to either remotely monitor or recognize another person's activity via the ubiquitous mobile device or by using sensor-based Internet of Things (IoT). Our proposed work focuses on the accurate classification of daily human activities from both accelerometer and gyroscope sensor data after converting into spectrogram images. The feature extraction process follows …

Scalable Causal Structure Learning: Scoping Review Of Traditional And Deep Learning Algorithms And New Opportunities In Biomedicine, Pulakesh Upadhyaya, Kai Zhang, Can Li, Xiaoqian Jiang, Yejin Kim

Faculty, Staff and Student Publications

BACKGROUND: Causal structure learning refers to a process of identifying causal structures from observational data, and it can have multiple applications in biomedicine and health care.

OBJECTIVE: This paper provides a practical review and tutorial on scalable causal structure learning models with examples of real-world data to help health care audiences understand and apply them.

METHODS: We reviewed traditional (combinatorial and score-based) methods for causal structure discovery and machine learning-based schemes. Various traditional approaches have been studied to tackle this problem, the most important among these being the Peter Spirtes and Clark Glymour algorithms. This was followed by analyzing the …

Psychometric Properties Of A Combined Go/No-Go And Continuous Performance Task Across Childhood, Caron A.C. Clark, Kaitlyn Cook, Rui Wang, Michael Rueschman, Jerilynn Radcliffe, Susan Redline, H. Gerry Taylor

Statistical and Data Sciences: Faculty Publications

Despite the critical importance of attention for children’s self-regulation and mental health, there are few task-based measures of this construct appropriate for use across a wide childhood age range including very young children. Three versions of a combined go/no-go and continuous performance task (GNG/CPT) were created with varying length and timing parameters to maximize their appropriateness for age groups spanning early to middle childhood. As part of the baseline assessment of a clinical trial, 452 children aged 3–12 years (50% male, 50% female; 52% White, non-Hispanic, 27% Black, 16% Hispanic/Latinx; 6% other ethnicity/race) completed the task. Confirmatory factor analysis indicated …

Visual Analytics And Modeling Of Materials Property Data, Diwas Bhattarai

LSU Doctoral Dissertations

Due to significant advancements in experimental and computational techniques, materials data are abundant. To facilitate data-driven research, it calls for a system for managing and sharing data and supporting a set of tools for effective data analysis and modeling. Generally, a given material property M can be considered as a multivariate data problem. The dimensions of M are the values of the property itself, the conditions (pressure P, temperature T, and multi-component composition X) that control the concerned property, and relevant metadata I (source, date).

Here we present a comprehensive database considering both experimental and computational sources …

Ageanno: A Knowledgebase Of Single-Cell Annotation Of Aging In Human, Kexin Huang, Hoaran Gong, Jingjing Guan, Lingxiao Zhang, Changbao Hu, Weiling Zhao, Liyu Huang, Wei Zhang, Pora Kim, Xiaobo Zhou

Faculty, Staff and Student Publications

Aging is a complex process that accompanied by molecular and cellular alterations. The identification of tissue-/cell type-specific biomarkers of aging and elucidation of the detailed biological mechanisms of aging-related genes at the single-cell level can help to understand the heterogeneous aging process and design targeted anti-aging therapeutics. Here, we built AgeAnno (https://relab.xidian.edu.cn/AgeAnno/#/), a knowledgebase of single cell annotation of aging in human, aiming to provide comprehensive characterizations for aging-related genes across diverse tissue-cell types in human by using single-cell RNA and ATAC sequencing data (scRNA and scATAC). The current version of AgeAnno houses 1 678 610 cells from 28 healthy …

Spascer: Spatial Transcriptomics Annotation At Single-Cell Resolution, Zhiwei Fan, Yangyang Luo, Huifen Lu, Tiangang Wang, Yuzhou Feng, Weiling Zhao, Pora Kim, Xiaobo Zhou

Faculty, Staff and Student Publications

In recent years, the explosive growth of spatial technologies has enabled the characterization of spatial heterogeneity of tissue architectures. Compared to traditional sequencing, spatial transcriptomics reserves the spatial information of each captured location and provides novel insights into diverse spatially related biological contexts. Even though two spatial transcriptomics databases exist, they provide limited analytical information. Information such as spatial heterogeneity of genes and cells, cell-cell communication activities in space, and the cell type compositions in the microenvironment are critical clues to unveil the mechanism of tumorigenesis and embryo differentiation. Therefore, we constructed a new spatial transcriptomics database, named SPASCER (https://ccsm.uth.edu/SPASCER), …

Crow Search Algorithm With Time Varying Flight Length Strategies For Feature Selection, Mohammed Abdullahi, Abdulhameed Adamu, Ibrahim Hayatu Hassan

Future Computing and Informatics Journal

Feature Selection (FS) is an efficient technique use to get rid of irrelevant, redundant and noisy attributes in high dimensional datasets while increasing the efficacy of machine learning classification. The CSA is a modest and efficient metaheuristic algorithm which has been used to overcome several FS issues. The flight length (fl) parameter in CSA governs crows' search ability. In CSA, fl is set to a fixed value. As a result, the CSA is plagued by the problem of being hoodwinked in local minimum. This article suggests a remedy to this issue by bringing five new concepts of time dependent fl …

Metaenhance: Metadata Quality Improvement For Electronic Theses And Dissertations, Muntabir H. Choudhury, Lamia Salsabil, Himarsha R. Jayanetti, Jian Wu

College of Sciences Posters

Metadata quality is crucial for digital objects to be discovered through digital library interfaces. Although DL systems have adopted Dublin Core to standardize metadata formats (e.g., ETD-MS v1.1¹), the metadata of digital objects may contain incomplete, inconsistent, and incorrect values [1]. Most existing frameworks to improve metadata quality rely on crowdsourced correction approaches, e.g., [2]. Such methods are usually slow and biased toward documents that are more discoverable by users. Artificial intelligence (AI) based methods can be adopted to overcome this limit by automatically detecting, correcting, and canonicalizing the metadata, featuring quick and unbiased responses to document metadata. …

X-Disetrac: Distributed Eye-Tracking With Extended Realities, Bhanuka Mahanama, Sampath Jayarathna

College of Sciences Posters

Humans use heterogeneous collaboration mediums such as in-person, online, and extended realities for day-to-day activities. Identifying patterns in viewpoints and pupillary responses (a.k.a eye-tracking data) provide informative cues on individual and collective behavior during collaborative tasks. Despite the increasing ubiquity of these different mediums, the aggregation and analysis of eye-tracking data in heterogeneous collaborative environments remain unexplored. Our study proposes X-DisETrac: Extended Distributed Eye Tracking, a versatile framework for eye tracking in heterogeneous environments. Our approach tackles the complexity by establishing a platform-agnostic communication protocol encompassing three data streams to simplify data aggregation and …

Prevention Research Center For Healthy Neighborhoods, Madeline Panus

Celebration of Scholarship 2023

No abstract provided.