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Full-Text Articles in Data Science

Data Collection And Machine Learning Methods For Automated Pedestrian Facility Detection And Mensuration, Joseph Bailey Luttrell Iv Aug 2022

Data Collection And Machine Learning Methods For Automated Pedestrian Facility Detection And Mensuration, Joseph Bailey Luttrell Iv

Dissertations

Large-scale collection of pedestrian facility (crosswalks, sidewalks, etc.) presence data is vital to the success of efforts to improve pedestrian facility management, safety analysis, and road network planning. However, this kind of data is typically not available on a large scale due to the high labor and time costs that are the result of relying on manual data collection methods. Therefore, methods for automating this process using techniques such as machine learning are currently being explored by researchers. In our work, we mainly focus on machine learning methods for the detection of crosswalks and sidewalks from both aerial and street-view …


Parallel Algorithms For Scalable Graph Mining: Applications On Big Data And Machine Learning, Naw Safrin Sattar Aug 2022

Parallel Algorithms For Scalable Graph Mining: Applications On Big Data And Machine Learning, Naw Safrin Sattar

LSU New Orleans Theses and Dissertations

Parallel computing plays a crucial role in processing large-scale graph data. Complex network analysis is an exciting area of research for many applications in different scientific domains e.g., sociology, biology, online media, recommendation systems and many more. Graph mining is an area of interest with diverse problems from different domains of our daily life. Due to the advancement of data and computing technologies, graph data is growing at an enormous rate, for example, the number of links in social networks is growing every millisecond. Machine/Deep learning plays a significant role for technological accomplishments to work with big data in modern …


Ocean Wave Prediction And Characterization For Intelligent Maritime Transportation, Pujan Pokhrel Aug 2022

Ocean Wave Prediction And Characterization For Intelligent Maritime Transportation, Pujan Pokhrel

LSU New Orleans Theses and Dissertations

The national Earth System Prediction (ESPC) initiative aims to develop the predictions
for the next generation predictions of atmosphere, ocean, and sea-ice interactions in the scale of days to decades. This dissertation seeks to demonstrate the methods we can use to improve the ESPC models, especially the ocean prediction model. In the application side of the weather forecasts, this dissertation explores imitation learning with constraints to solve combinatorial optimization problems, focusing on the weather routing of surface vessels. Prediction of ocean waves is essential for various purposes, including vessel routing, ocean energy harvesting, agriculture, etc. Since the machine learning approaches …


Computer Aided Diagnosis System For Breast Cancer Using Deep Learning., Asma Baccouche Aug 2022

Computer Aided Diagnosis System For Breast Cancer Using Deep Learning., Asma Baccouche

Electronic Theses and Dissertations

The recent rise of big data technology surrounding the electronic systems and developed toolkits gave birth to new promises for Artificial Intelligence (AI). With the continuous use of data-centric systems and machines in our lives, such as social media, surveys, emails, reports, etc., there is no doubt that data has gained the center of attention by scientists and motivated them to provide more decision-making and operational support systems across multiple domains. With the recent breakthroughs in artificial intelligence, the use of machine learning and deep learning models have achieved remarkable advances in computer vision, ecommerce, cybersecurity, and healthcare. Particularly, numerous …


Unsupervised Contrastive Representation Learning For Knowledge Distillation And Clustering, Fei Ding Aug 2022

Unsupervised Contrastive Representation Learning For Knowledge Distillation And Clustering, Fei Ding

All Dissertations

Unsupervised contrastive learning has emerged as an important training strategy to learn representation by pulling positive samples closer and pushing negative samples apart in low-dimensional latent space. Usually, positive samples are the augmented versions of the same input and negative samples are from different inputs. Once the low-dimensional representations are learned, further analysis, such as clustering, and classification can be performed using the representations. Currently, there are two challenges in this framework. First, the empirical studies reveal that even though contrastive learning methods show great progress in representation learning on large model training, they do not work well for small …


Computational Models To Detect Radiation In Urban Environments: An Application Of Signal Processing Techniques And Neural Networks To Radiation Data Analysis, Jose Nicolas Gachancipa Jul 2022

Computational Models To Detect Radiation In Urban Environments: An Application Of Signal Processing Techniques And Neural Networks To Radiation Data Analysis, Jose Nicolas Gachancipa

Beyond: Undergraduate Research Journal

Radioactive sources, such as uranium-235, are nuclides that emit ionizing radiation, and which can be used to build nuclear weapons. In public areas, the presence of a radioactive nuclide can present a risk to the population, and therefore, it is imperative that threats are identified by radiological search and response teams in a timely and effective manner. In urban environments, such as densely populated cities, radioactive sources may be more difficult to detect, since background radiation produced by surrounding objects and structures (e.g., buildings, cars) can hinder the effective detection of unnatural radioactive material. This article presents a computational model …


Toward A Standard Formal Semantic Representation Of The Model Card Report, Muhammad Tuan Amith, Licong Cui, Degui Zhi, Kirk Roberts, Xiaoqian Jiang, Fang Li, Evan Yu, Cui Tao Jul 2022

Toward A Standard Formal Semantic Representation Of The Model Card Report, Muhammad Tuan Amith, Licong Cui, Degui Zhi, Kirk Roberts, Xiaoqian Jiang, Fang Li, Evan Yu, Cui Tao

Faculty, Staff and Student Publications

BACKGROUND: Model card reports aim to provide informative and transparent description of machine learning models to stakeholders. This report document is of interest to the National Institutes of Health's Bridge2AI initiative to address the FAIR challenges with artificial intelligence-based machine learning models for biomedical research. We present our early undertaking in developing an ontology for capturing the conceptual-level information embedded in model card reports.

RESULTS: Sourcing from existing ontologies and developing the core framework, we generated the Model Card Report Ontology. Our development efforts yielded an OWL2-based artifact that represents and formalizes model card report information. The current release of …


A Comparative Study On Deep Learning Models For Text Classification Of Unstructured Medical Notes With Various Levels Of Class Imbalance, Hongxia Lu, Louis Ehwerhemuepha, Cyril Rakovski Jul 2022

A Comparative Study On Deep Learning Models For Text Classification Of Unstructured Medical Notes With Various Levels Of Class Imbalance, Hongxia Lu, Louis Ehwerhemuepha, Cyril Rakovski

Mathematics, Physics, and Computer Science Faculty Articles and Research

Background

Discharge medical notes written by physicians contain important information about the health condition of patients. Many deep learning algorithms have been successfully applied to extract important information from unstructured medical notes data that can entail subsequent actionable results in the medical domain. This study aims to explore the model performance of various deep learning algorithms in text classification tasks on medical notes with respect to different disease class imbalance scenarios.

Methods

In this study, we employed seven artificial intelligence models, a CNN (Convolutional Neural Network), a Transformer encoder, a pretrained BERT (Bidirectional Encoder Representations from Transformers), and four typical …


Leveraging Context Patterns For Medical Entity Classification, Garrett Johnston Jun 2022

Leveraging Context Patterns For Medical Entity Classification, Garrett Johnston

Computer Science Senior Theses

The ability of patients to understand health-related text is important for optimal health outcomes. A system that can automatically annotate medical entities could help patients better understand health-related text. Such a system would also accelerate manual data annotation for this low-resource domain as well as assist in down- stream medical NLP tasks such as finding textual similarity, identifying conflicting medical advice, and aspect-based sentiment analysis. In this work, we investigate a state-of-the-art entity set expansion model, BootstrapNet, for the task of medical entity classification on a new dataset of medical advice text. We also propose EP SBERT, a simple model …


Effect Of Monetary Policy Rate On Market Interest Rates In Nigeria: A Threshold And Nardl Approach, Oluwafemi E. Awopegba, Joseph O. Afolabi, Lydia T. Adeoye, Godwin O. Akpokodje Jun 2022

Effect Of Monetary Policy Rate On Market Interest Rates In Nigeria: A Threshold And Nardl Approach, Oluwafemi E. Awopegba, Joseph O. Afolabi, Lydia T. Adeoye, Godwin O. Akpokodje

CBN Journal of Applied Statistics (JAS)

This study examines the effect of monetary policy rate (MPR) on market interest rates in Nigeria. For parsimony, we develop two indexes called the short-term interest rate (SINT) and Lending interest rate (LINT) to represent deposit and lending rates respectively. The nonlinear autoregressive distributed lag (NARDL) and threshold regression models are adopted. The study uses monthly data from 2002:M1 to 2019:M12. The results of the threshold regression model indicate that the degree of the effect of MPR on SINT and LINT above the estimated threshold of 11 and 13 percent respectively is greater and significant than if MPR were to …


Social Dimension Of Inclusive Growth In Ecowas: Implication For Poverty Reduction, Toriola K. Anu, Goerge O. Emmanuel, Ajayi O. Felix Jun 2022

Social Dimension Of Inclusive Growth In Ecowas: Implication For Poverty Reduction, Toriola K. Anu, Goerge O. Emmanuel, Ajayi O. Felix

CBN Journal of Applied Statistics (JAS)

This study investigates the implication of the social dimension of inclusive growth on poverty reduction in Economic Community of West African States (ECOWAS) countries. It specifically examines how social indices of inclusive growth comprising of income inequality, education, and health outcomes affect poverty reduction. The study uses a panel dataset of the six (6) lower-middle income countries in ECOWAS which was analysed via panel Difference Generalised Method of Moment (D-GMM). The results show that GDP per capita exerts significant negative effect on poverty while inequality, education and health outcomes do not show significant effect on poverty. Although, the estimates of …


Effect Of Fdi Inflows On Employment Generation In Selected Ecowas Countries: Heterogeneous Panel Analysis, Timothy A. Aderemi, Olawunmi Omitogun, Bukonla G. Osisanwo Jun 2022

Effect Of Fdi Inflows On Employment Generation In Selected Ecowas Countries: Heterogeneous Panel Analysis, Timothy A. Aderemi, Olawunmi Omitogun, Bukonla G. Osisanwo

CBN Journal of Applied Statistics (JAS)

The aim of this study is to examine the effect of FDI on employment in ECOWAS sub region between 1990 and 2019. The study utilizes a panel autoregressive distributed lag model to analyse the short run and long run relationship between FDI and employment across ECOWAS sub region. In the short run, the impact of FDI on employment is negative and statistically not significant. Meanwhile, in the long run FDI has a positive and statistically significant impact on employment rate. This implies that FDI has the capacity to generate employment in countries in ECOWAS sub region. Therefore, this study recommends …


Impact Of Covid-19 Pandemic On The Nigeria Stock Market: A Sectoral Stock Prices Analysis, Peter A. Adekunle, Yakubu A. Bello, Udochukwu G. Nwachukwu Jun 2022

Impact Of Covid-19 Pandemic On The Nigeria Stock Market: A Sectoral Stock Prices Analysis, Peter A. Adekunle, Yakubu A. Bello, Udochukwu G. Nwachukwu

CBN Journal of Applied Statistics (JAS)

This study examines the impact of the COVID-19 pandemic on sectoral stock prices in Nigeria stock market using daily data covering from February 28, 2020 to June 26, 2020. Applying the autoregressive distributed lag (ARDL) bounds test, the study finds that COVID-19 pandemic had adverse impact on the stock market indices in the short run. Furthermore, the study documents negative response of sectoral stock prices to the pandemic while the stock prices of the banking sub-sector are the worst hit. Compared to the consumer goods, and industrial subsector indices, the speed of adjustment to long run equilibrium is faster for …


Representation Learning In Finance, Ajim Uddin May 2022

Representation Learning In Finance, Ajim Uddin

Dissertations

Finance studies often employ heterogeneous datasets from different sources with different structures and frequencies. Some data are noisy, sparse, and unbalanced with missing values; some are unstructured, containing text or networks. Traditional techniques often struggle to combine and effectively extract information from these datasets. This work explores representation learning as a proven machine learning technique in learning informative embedding from complex, noisy, and dynamic financial data. This dissertation proposes novel factorization algorithms and network modeling techniques to learn the local and global representation of data in two specific financial applications: analysts’ earnings forecasts and asset pricing.

Financial analysts’ earnings forecast …


Un-Fair Trojan: Targeted Backdoor Attacks Against Model Fairness, Nicholas Furth May 2022

Un-Fair Trojan: Targeted Backdoor Attacks Against Model Fairness, Nicholas Furth

Theses

Machine learning models have been shown to be vulnerable against various backdoor and data poisoning attacks that adversely affect model behavior. Additionally, these attacks have been shown to make unfair predictions with respect to certain protected features. In federated learning, multiple local models contribute to a single global model communicating only using local gradients, the issue of attacks become more prevalent and complex. Previously published works revolve around solving these issues both individually and jointly. However, there has been little study on the effects of attacks against model fairness. Demonstrated in this work, a flexible attack, which we call Un-Fair …


Real Time Call-Flagging System To Respond To Suicidal Ideation In Call Centers, Vishnu Menon, Joseph Carrigan, Charles Floeder, Thomas Walton, Devin Mcguire May 2022

Real Time Call-Flagging System To Respond To Suicidal Ideation In Call Centers, Vishnu Menon, Joseph Carrigan, Charles Floeder, Thomas Walton, Devin Mcguire

Honors Program: Senior Projects (Public)

The 2021-2022 Signature Performance Design Studio team developed a live audio call-flagging system that enables faster responses and new response pathways to veteran crises by call service representatives and their management team. Using a custom made deep learning model, live audio streaming server, and Teams broadcasting add-on, the system empowers Signature Performance call service representatives to make quicker and more well informed decisions to provide veteran’s the best care possible.


Building An Artificial Intelligence Framework For Hypertension Diagnosis: A Use Case Of The Problem List Curation, Ketemwabi Yves Shamavu May 2022

Building An Artificial Intelligence Framework For Hypertension Diagnosis: A Use Case Of The Problem List Curation, Ketemwabi Yves Shamavu

Theses & Dissertations

Hypertension is the world's leading factor in cardiovascular disease. Forty-seven percent or close to one in two Americans aged 18 and older are affected. It predicts approximately a thousand deaths per day. Based on recent statistics from the Centers for Disease Control and Prevention, one in three patients with hypertension does not know they are hypertensive. Seventy-five percent of hypertensive patients have uncontrolled hypertension - meaning that they are not treated to target. While there is extensive literature on hypertension diagnosis and management, there is an apparent gap in understanding and acknowledging that a person is hypertensive. Moreover, blood pressure …


Computational Approaches To Facilitate Automated Interchange Between Music And Art, Rao Hamza Ali May 2022

Computational Approaches To Facilitate Automated Interchange Between Music And Art, Rao Hamza Ali

Computational and Data Sciences (PhD) Dissertations

Recently, there has been a tremendous increase in generating and synthesizing music and art using various computational techniques. An area that is still under-researched, however, is how one medium can be converted into the other, while maintaining the overall aesthetics. Over the last few centuries, artists, composers, and scholars, have attempted to use substitute one form of art for the other: by proposing techniques where music notes are synonymous to colors, by inventing instruments that combine the aesthetics of music and visual art, and by incorporating the two media in live performances. A widely accepted computational approach, for the conversion, …


Data And Algorithmic Modeling Approaches To Count Data, Andraya Hack May 2022

Data And Algorithmic Modeling Approaches To Count Data, Andraya Hack

Honors College Theses

Various techniques are used to create predictions based on count data. This type of data takes the form of a non-negative integers such as the number of claims an insurance policy holder may make. These predictions can allow people to prepare for likely outcomes. Thus, it is important to know how accurate the predictions are. Traditional statistical approaches for predicting count data include Poisson regression as well as negative binomial regression. Both methods also have a zero-inflated version that can be used when the data has an overabundance of zeros. Another procedure is to use computer algorithms, also known as …


New Debiasing Strategies In Collaborative Filtering Recommender Systems: Modeling User Conformity, Multiple Biases, And Causality., Mariem Boujelbene May 2022

New Debiasing Strategies In Collaborative Filtering Recommender Systems: Modeling User Conformity, Multiple Biases, And Causality., Mariem Boujelbene

Electronic Theses and Dissertations

Recommender Systems are widely used to personalize the user experience in a diverse set of online applications ranging from e-commerce and education to social media and online entertainment. These State of the Art AI systems can suffer from several biases that may occur at different stages of the recommendation life-cycle. For instance, using biased data to train recommendation models may lead to several issues, such as the discrepancy between online and offline evaluation, decreasing the recommendation performance, and hurting the user experience. Bias can occur during the data collection stage where the data inherits the user-item interaction biases, such as …


Beyond Accuracy In Machine Learning., Aneseh Alvanpour May 2022

Beyond Accuracy In Machine Learning., Aneseh Alvanpour

Electronic Theses and Dissertations

Machine Learning (ML) algorithms are widely used in our daily lives. The need to increase the accuracy of ML models has led to building increasingly powerful and complex algorithms known as black-box models which do not provide any explanations about the reasons behind their output. On the other hand, there are white-box ML models which are inherently interpretable while having lower accuracy compared to black-box models. To have a productive and practical algorithmic decision system, precise predictions may not be sufficient. The system may need to have transparency and be able to provide explanations, especially in applications with safety-critical contexts …


Intra-Hour Solar Forecasting Using Cloud Dynamics Features Extracted From Ground-Based Infrared Sky Images, Guillermo Terrén-Serrano Apr 2022

Intra-Hour Solar Forecasting Using Cloud Dynamics Features Extracted From Ground-Based Infrared Sky Images, Guillermo Terrén-Serrano

Electrical and Computer Engineering ETDs

Due to the increasing use of photovoltaic systems, power grids are vulnerable to the projection of shadows from moving clouds. An intra-hour solar forecast provides power grids with the capability of automatically controlling the dispatch of energy, reducing the additional cost for a guaranteed, reliable supply of energy (i.e., energy storage). This dissertation introduces a novel sky imager consisting of a long-wave radiometric infrared camera and a visible light camera with a fisheye lens. The imager is mounted on a solar tracker to maintain the Sun in the center of the images throughout the day, reducing the scattering effect produced …


Toward Suicidal Ideation Detection With Lexical Network Features And Machine Learning, Ulya Bayram, William Lee, Daniel Santel, Ali Minai, Peggy Clark, Tracy Glauser, John Pestian Apr 2022

Toward Suicidal Ideation Detection With Lexical Network Features And Machine Learning, Ulya Bayram, William Lee, Daniel Santel, Ali Minai, Peggy Clark, Tracy Glauser, John Pestian

Northeast Journal of Complex Systems (NEJCS)

In this study, we introduce a new network feature for detecting suicidal ideation from clinical texts and conduct various additional experiments to enrich the state of knowledge. We evaluate statistical features with and without stopwords, use lexical networks for feature extraction and classification, and compare the results with standard machine learning methods using a logistic classifier, a neural network, and a deep learning method. We utilize three text collections. The first two contain transcriptions of interviews conducted by experts with suicidal (n=161 patients that experienced severe ideation) and control subjects (n=153). The third collection consists of interviews conducted by experts …


Unsupervised Learning With Word Embeddings Captures Quiescent Knowledge From Covid-19 And Materials Science Literature, Tasnim H. Gharaibeh Apr 2022

Unsupervised Learning With Word Embeddings Captures Quiescent Knowledge From Covid-19 And Materials Science Literature, Tasnim H. Gharaibeh

Dissertations

Millions of scientific papers are produced each year and the scientific literature is continuing to grow at a head-spinning speed. Thus, massive scientific knowledge exists in solid text, but all these publications make it difficult, if not impossible, for researchers to keep in up to date with discoveries, even within a narrow scientific area. This massive amount of information also makes it difficult to find implicit and hidden connections, relationships, and dependencies within the information that may guide the direction of future research or lead to valuable new insights. So, there is a need for algorithms or models that can …


Assessing Photogrammetry Artificial Intelligence In Monumental Buildings’ Crack Digital Detection, Said Maroun, Mostafa Khalifa, Nabil Mohareb Mar 2022

Assessing Photogrammetry Artificial Intelligence In Monumental Buildings’ Crack Digital Detection, Said Maroun, Mostafa Khalifa, Nabil Mohareb

Architecture and Planning Journal (APJ)

Natural and human-made disasters have significant impacts on monumental buildings, threatening them from being deteriorated. If no rapid consolidations took into consideration traumatic accidents would endanger the existence of precious sites. In this context, Beirut's enormous 4th of August 2020 explosion damaged an estimated 640 historical monuments, many volunteers assess damages for more than a year to prevent the more crucial risk of demolitions. This research aims to assist the collaboration ability among photogrammetry science, Artificial Intelligence Model (AIM) and Architectural Coding to optimize the process for better coverage and scientific approach of data specific to the crack disorders to …


Objective Measure Of Working Memory Capacity Using Eye Movements, James Owens, Gavindya Jayawardena, Yasasi Abeysinghe, Vikas G. Ashok, Sampath Jayarathna Mar 2022

Objective Measure Of Working Memory Capacity Using Eye Movements, James Owens, Gavindya Jayawardena, Yasasi Abeysinghe, Vikas G. Ashok, Sampath Jayarathna

Undergraduate Research Symposium

Human-autonomy teaming (HAT) has become an important area of research due to the autonomous systems being developed for different applications, such as remotely controlled aircraft. Many remotely controlled vehicles will be controlled by automated systems, with a human monitor that may be monitoring multiple vehicles simultaneously. The attention and working memory capacity of operators of remote-controlled vehicles must be maintained at appropriate levels during operation. However, there is currently no direct method of determining working memory capacity, which is important because it is a measure for how memory is being stored for a short term and interacting with long term …


Autonomous, Long-Range, Sensor Emplacement Using Unmanned Aircraft Systems, Adam Plowcha, Justin Bradley, Jacob Hoberg, Thomas Ammon, Mark Nail, Brittany Duncan, Carrick Detweiler Mar 2022

Autonomous, Long-Range, Sensor Emplacement Using Unmanned Aircraft Systems, Adam Plowcha, Justin Bradley, Jacob Hoberg, Thomas Ammon, Mark Nail, Brittany Duncan, Carrick Detweiler

School of Computing: Faculty Publications

Automated, in-ground sensor emplacement can significantly improve remote, terrestrial, data collection capabilities. Utilizing a multicopter, unmanned aircraft system (UAS) for this purpose allows sensor insertion with minimal disturbance to the target site or surrounding area. However, developing an emplacement mechanism for a small multicopter, autonomy to manage the target selection and implantation process, as well as long-range deployment are challenging to address. We have developed an autonomous, multicopter UAS that can implant subsurface sensor devices. We enhanced the UAS autopilot with autonomy for target and landing zone selection, as well as ensuring the sensor is implanted properly in the ground. …


Leveraging Machine Learning For Large Scale Analysis Of Publicly-Available Data For Gnss Interference Events, David K. Stamper Mar 2022

Leveraging Machine Learning For Large Scale Analysis Of Publicly-Available Data For Gnss Interference Events, David K. Stamper

Theses and Dissertations

This research documents architecture and implementation of an enhanced interference detection and classification analysis system, using both a database and storage solution utilizing machine learning algorithms to detect changes in Carrier-to-Noise strength over multiple GNSS sites. The system uses publicly-available government supported receivers to detect interference, and built using FOSS packaged as a programming library through Python. Two algorithms are discussed in terms of enhancing interference detection using both non-machine learning and machine learning approaches. Two algorithms are also discussed which are used for classification of events. In addition, an approach to Large Scale data analytics is demonstrated via a …


Iseeq: Information Seeking Question Generation Using Dynamic Meta-Information Retrieval And Knowledge Graphs, Manas Gaur, Kalpa Gunaratna, Vijay Srinivasan, Hongxia Jin Feb 2022

Iseeq: Information Seeking Question Generation Using Dynamic Meta-Information Retrieval And Knowledge Graphs, Manas Gaur, Kalpa Gunaratna, Vijay Srinivasan, Hongxia Jin

Publications

Conversational Information Seeking (CIS) is a relatively new research area within conversational AI that attempts to seek information from end-users in order to understand and satisfy users’ needs. If realized, such a system has far-reaching benefits in the real world; for example, a CIS system can assist clinicians in pre-screening or triaging patients in healthcare. A key open sub-problem in CIS that remains unaddressed in the literature is generating Information Seeking Questions (ISQs) based on a short initial query from the end user. To address this open problem, we propose Information SEEking Question generator (ISEEQ), a novel approach for generating …


Representation Learning For Chemical Activity Predictions, Mohamed S. Ayed Feb 2022

Representation Learning For Chemical Activity Predictions, Mohamed S. Ayed

Dissertations, Theses, and Capstone Projects

Computational prediction of a phenotypic response upon the chemical perturbation on a biological system plays an important role in drug discovery and many other applications. Chemical fingerprints derived from chemical structures are a widely used feature to build machine learning models. However, the fingerprints ignore the biological context, thus, they suffer from several problems such as the activity cliff and curse of dimensionality. Fundamentally, the chemical modulation of biological activities is a multi-scale process. It is the genome-wide chemical-target interactions that modulate chemical phenotypic responses. Thus, the genome-scale chemical-target interaction profile will more directly correlate with in vitro and in …