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Valid Time Rdf, Hsien-Tseng Wang
Valid Time Rdf, Hsien-Tseng Wang
Dissertations, Theses, and Capstone Projects
The Semantic Web aims at building a foundation of semantic-based data models and languages for not only manipulating data and knowledge, but also supporting decision making by machines. Naturally, time-varying data and knowledge are required in Semantic Web applications to incorporate time and further reason about it. However, the original specifications of Resource Description Framework (RDF) and Web Ontology Language (OWL) do not include constructs for handling time-varying data and knowledge. For simplicity, RDF model is confined to binary predicates, hence some form of reification is needed to represent higher-arity predicates. To this date, there are many proposals extending RDF …
Machine Learning Applications For Drug Repurposing, Hansaim Lim
Machine Learning Applications For Drug Repurposing, Hansaim Lim
Dissertations, Theses, and Capstone Projects
The cost of bringing a drug to market is astounding and the failure rate is intimidating. Drug discovery has been of limited success under the conventional reductionist model of one-drug-one-gene-one-disease paradigm, where a single disease-associated gene is identified and a molecular binder to the specific target is subsequently designed. Under the simplistic paradigm of drug discovery, a drug molecule is assumed to interact only with the intended on-target. However, small molecular drugs often interact with multiple targets, and those off-target interactions are not considered under the conventional paradigm. As a result, drug-induced side effects and adverse reactions are often neglected …