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Stereoselective Synthesis Of 3,7-Diarylaminocholestanes By Titanium-Mediated Reductive Amination, Md Wasi Ahmad, Hong Seok Kim

Dr. Mohammad Wasi Ahmad (Md Wasi Ahmad)

An efficient method for the synthesis of aryl aminocholestanes, using a chlorotriisopropoxytitanium (IV)-mediated reductive amination reaction of 5a-cholestane-3,7-dione, is reported. A series of 3, 7-diarylaminocholestane derivatives were prepared according to this methodology in up to 98% yield. These compounds were primarily characterized by 1H NMR, 13C NMR, and mass spectrometry.