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Beta-Peptides With Improved Affinity For Hdm2 And Hdmx, Elizabeth A. Harker, Douglas S. Daniels, Danielle A. Guarracino, Alanna S. Schepartz
Beta-Peptides With Improved Affinity For Hdm2 And Hdmx, Elizabeth A. Harker, Douglas S. Daniels, Danielle A. Guarracino, Alanna S. Schepartz
Chemistry Faculty Publications
We previously described a series of 314-helical β-peptides that bind the hDM2 protein and inhibit its interaction with a p53-derived peptide in vitro. Here we present a detailed characterization of the interaction of these peptides with hDM2 and report two new β-peptides in which non-natural side chains have been substituted into the hDM2-recognition epitope. These peptides feature both improved affinity and inhibitory potency in fluorescence polarization and ELISA assays. Additionally, one of the new β-peptides also binds the hDM2-related protein, hDMX, which has been identified as another key therapeutic target for activation of the p53 pathway in tumors.
Preparation And Characterization Of Some Substituted Benzyl N-Nitrosocarbamates Containing An N-2-(Methylthio)Ethyl Or A Bis(2-Aminoethyl)Sulfide Functionality, Satya Venkata, Eric Shamo, Vladimir Benin
Preparation And Characterization Of Some Substituted Benzyl N-Nitrosocarbamates Containing An N-2-(Methylthio)Ethyl Or A Bis(2-Aminoethyl)Sulfide Functionality, Satya Venkata, Eric Shamo, Vladimir Benin
Chemistry Faculty Publications
The synthesis and characterization of some substituted benzyl N-nitrosocarbamates with an N-2-(methylthio)ethyl or a bis(2-aminoethyl)sulfide functionality is reported, as a part of a long-term goal to design and prepare novel photolabile structures that could be used as substances for controlled release of alkylating and/or crosslinking agents. The synthesis was accomplished by reaction of benzyl chloroformates with the corresponding amines, resulting in the preparation of carbamates. The latter were subsequently nitrosated, utilizing two different N-nitrosation methods, to yield the target structures.
Radical Bonding: Structure And Stability Of Bis(Phenalenyl) Complexes Of Divalent Metals From Across The Periodic Table, Smaranda Craciun, Kelling J. Donald
Radical Bonding: Structure And Stability Of Bis(Phenalenyl) Complexes Of Divalent Metals From Across The Periodic Table, Smaranda Craciun, Kelling J. Donald
Chemistry Faculty Publications
We examine the bonding possibilities of the bis(phenalenyl) MP2 sandwich complexes of the divalent metals M = Be, Mg, Ca, Sr, Ba, Zn, Cd, and Hg, at the B3LYP level of theory. The outcome is an extraordinarily diverse class of low symmetry bis(phenalenyl)metal complexes in which bonding preferences and binding enthalpies differ dramatically. The lowest energy group 2 metal MP2 complexes include an intriguing η1,η3 BeP2 structure, and bent η6,η6 systems for M = Ca, Sr, and Ba. The group 12 bis(phenalenyl) complexes are thermodynamically unstable η1, …