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An Investigation Into The Adduct Forming Potential Of Drugs Of Abuse With Peptides And Proteins, Richard Allen Gilliland
An Investigation Into The Adduct Forming Potential Of Drugs Of Abuse With Peptides And Proteins, Richard Allen Gilliland
FIU Electronic Theses and Dissertations
Hemoglobin and serum albumin, two prevalent proteins in human blood, contain unbound cysteine thiol moieties, creating a nucleophilic site with the potential for covalent modification by reactive chemical species. These covalent modifications, called “adducts”, are stable entities that accumulate during acute and chronic exposure and remain covalently bound for the life-span of the protein. Despite their current use as exposure markers for a variety of compounds, the use of adducts in assessing exposure to drugs of abuse has not yet been explored. The goal of this work was to examine the in vitro adduct forming capability of selected drugs of …
Development Of Presumptive And Confirmatory Analytical Methods For The Simultaneous Detection Of Multiple Improvised Explosives, Kelley L. Peters
Development Of Presumptive And Confirmatory Analytical Methods For The Simultaneous Detection Of Multiple Improvised Explosives, Kelley L. Peters
FIU Electronic Theses and Dissertations
In recent years, there has been a dramatic increase in the use of improvised explosive devices (IEDs) due to ease of synthesis and improved controls placed on commercial/military explosives. Commonly used materials for IED preparations include fertilizers and industrial chemicals containing oxidizers such as ClO3-, ClO4-, and NO3-, as well as other less stable compounds, such as peroxides. Due to these materials having a wide range of volatility, polarity, and composition, detection can be challenging, increasing the amount of time before any analytical information on the identity of the explosive can …