Other Chemistry Commons^™

Forensic Toxicological Screening And Confirmation Of 800+ Novel Psychoactive Substances By Lc-Qtof-Ms And 2d-Lc Analysis, Melanie N. Eckberg

FIU Electronic Theses and Dissertations

Novel psychoactive substances (NPS) represent a great challenge to toxicologists due to the ability of illicit drug manufacturers to alter NPS chemical structures quickly and with ease to circumvent legislation regulating their use. Each time a new structure is introduced, there is a possibility that it has not been previously recorded in law enforcement or scientific databases. Many toxicology laboratories use targeted analytical methods that rely on libraries of known compounds to identify drugs in samples. However, these libraries do not include large numbers of NPS which could result in non-identification or detection.

High-resolution mass spectrometry (HRMS) has been suggested …