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Full-Text Articles in Chemistry
Synthesis And Protection Of Nitrogen Containing Heterocycles, Timothy I. Elwell
Synthesis And Protection Of Nitrogen Containing Heterocycles, Timothy I. Elwell
Undergraduate Honors Capstone Projects
The pyrrolo[2,3-d] pyrimidine ring systems are present in a variety of antibacterial/anticancer compounds. A scarcity of natural sources has made necessary the need for researchers to find more efficient methodologies to synthesize such compounds.1 The Edstrom research group is currently exploring new routes to these compounds, varying the protecting groups and the precursors used to make them.
Efficient And General Synthesis Of Novel Β-Polyfluoroalkoxy Vinamidinium Salts, Koichiro Kase, Mitsuyoshi Katayama, Takashi Ishihara, Hiroki Yamanaka, John T. Gupton
Efficient And General Synthesis Of Novel Β-Polyfluoroalkoxy Vinamidinium Salts, Koichiro Kase, Mitsuyoshi Katayama, Takashi Ishihara, Hiroki Yamanaka, John T. Gupton
Chemistry Faculty Publications
Novel β-polyfluoroalkoxy vinamidinium salts 3 and/or 4 were synthesized in good yields by the reaction of N-(2- polyfluoroalkoxy-3 ,3-difluoro-1-propenyI)trimethylammonium iodides (2), prepared from N-(2,3,3-trifluoro-1-propenyl)trimethylammonium iodide (1), with secondary amines in MeCN at 70 °C for 1 h. The salts were also obtainable in comparable yields by the one-pot reaction of 1 with sodium polyfluoroalkoxide followed by treatment with amines.