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Microwave-Assisted Polystyrene Sulfonatecatalyzed Synthesis Of Novel Pyrroles, Rosario Astrid Vargas Cardenas, Blanca Olinda Quintanilla Leal, Ashwini Reddy, Debasish Bandyopadhyay, Bimal K. Banik
Microwave-Assisted Polystyrene Sulfonatecatalyzed Synthesis Of Novel Pyrroles, Rosario Astrid Vargas Cardenas, Blanca Olinda Quintanilla Leal, Ashwini Reddy, Debasish Bandyopadhyay, Bimal K. Banik
Chemistry Faculty Publications and Presentations
Background: Pyrroles are widely distributed in nature and important biologically active molecules. The reaction of amines with 2,5-dimethoxytetrahydrofuran is a promising pathway for the synthesis of pharmacologically active pyrroles under microwave irradiation.
Results: Microwave-induced polystyrenesulfonate-catalyzed synthesis of pyrroles from amines and 2,5- diemthoxytetrahydrofuran has been accomplished with excellent yield. This method produces pyrroles with polyaromatic amines.
Conclusion: The present procedure for the synthesis of N-aromatic substituted pyrroles will find useful application in the area of pharmacologically active molecules.