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Bifurcation

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Full-Text Articles in Applied Mathematics

Dynamics Of Prey-Prey Mutualism With Varying Carrying Capacity And Herd Behavior In The Presence Of Predator, Felix Dela Djokoto Jan 2025

Dynamics Of Prey-Prey Mutualism With Varying Carrying Capacity And Herd Behavior In The Presence Of Predator, Felix Dela Djokoto

UNF Graduate Theses and Dissertations

This study investigates the dynamics of mutualistic relationships between two prey species in the presence of a predator, by taking into account herding in one species along with the influence of carrying capacities between two prey species. These mutualistic dynamics are presented by constructing two mathematical models, namely an indirect and direct mutualism model. As the strength of the symbiotic relationship increases the indirect model goes through transcritical bifurcation to Hopf bifurcation whereas in the direct mutualism model goes through saddle-node bifurcation to Hopf bifurcation.


(R2102) Chaos Measure In A Discrete Sir Epidemic Model With Constant Recovery, Sonia Aneja, Itendra Kumar, Sada Nand Prasad Dec 2024

(R2102) Chaos Measure In A Discrete Sir Epidemic Model With Constant Recovery, Sonia Aneja, Itendra Kumar, Sada Nand Prasad

Applications and Applied Mathematics: An International Journal (AAM)

A discrete SIR epidemic model with constant recovery and bilinear incidence rate is investigated for emergence of regular and chaotic behaviour in the context of non linear dynamics and different viable settings. The Euler’s discretization method is employed to transform the continuous epidemic model into discrete model which has been used as the study model. Attention is paid to various bifurcation plots obtained by varying certain system parameters while keeping other parameters constant. Bifurcations indicate regular evolution followed by chaos. Regular and chaotic attractors have been drawn in the process. As part of chaos measure, numerical studies are extended to …


The Computational Search For Unidentified Central Configurations Of The Newtonian N-Body Problem, Hannah G. Havel Jan 2024

The Computational Search For Unidentified Central Configurations Of The Newtonian N-Body Problem, Hannah G. Havel

CURE Proceedings

The N-body problem is a field of study in mathematics and physics that involves predicting the motion of particles moving under their mutual gravitational attraction. It is vital in celestial mechanics, such as planning collision-free satellite orbit trajectories. When beginning to understand the N-body problem, we can start by looking at equal masses of these particles or celestial bodies. As particles move, their position and velocity change, both energy and angular momentum are conserved. Sets of constant energy and angular momentum, known as integral manifolds, are higher-dimensional figures that represent constraints of movement to a system. Integral manifolds are described …


Bifurcation Levels Of The Integral Manifolds Of The Newtonian N-Body Problem, Hannah G. Havel Jan 2023

Bifurcation Levels Of The Integral Manifolds Of The Newtonian N-Body Problem, Hannah G. Havel

CURE Proceedings

The N-body problem, first proposed by Isaac Newton, is a field of study in mathematics and physics that involves predicting the motion of particles moving under their mutual gravitational attraction. It has significance to many areas of science, including physics and computer science, and is crucial in understanding how the universe works. In fact, it was a primary motivation for Newton's development of calculus. An important application of the N-body problem is within celestial mechanics and involves how planets and other celestial bodies move with mutual gravitational attraction. It is important in developing how satellites behave in space using complicated …


(Si10-056) Fear Effect In A Three Species Prey-Predator Food-Web System With Harvesting, R. P. Gupta, Dinesh K. Yadav Oct 2022

(Si10-056) Fear Effect In A Three Species Prey-Predator Food-Web System With Harvesting, R. P. Gupta, Dinesh K. Yadav

Applications and Applied Mathematics: An International Journal (AAM)

Some recent studies and field experiments show that predators affect their prey not only by direct capture; they also induce fear in prey species, which reduces their reproduction rate. Considering this fact, we propose a mathematical model to study the fear effect of a middle predator on its prey in a three-species food web system with harvesting. The ecological feasibility of solutions to the proposed system is guaranteed in terms of positivity and boundedness. The local stability of stationary points in the proposed system is derived. Multiple co-existing stationary points for the proposed system are observed, which makes the problem …


(R1889) Analysis Of Resonant Curve In The Earth-Moon System Under The Effect Of Resistive Force And Earth’S Equatorial Ellipticity, Sushil Yadav, Mukesh Kumar, Rajiv Aggarwal Jun 2022

(R1889) Analysis Of Resonant Curve In The Earth-Moon System Under The Effect Of Resistive Force And Earth’S Equatorial Ellipticity, Sushil Yadav, Mukesh Kumar, Rajiv Aggarwal

Applications and Applied Mathematics: An International Journal (AAM)

In the present paper, we have determined the equations of motion of the Moon in spherical coordinate system using the gravitational potential of Earth. Using perturbation, equations of motion are reduced to a second order differential equation. From the solution, two types of resonance are observed: (i) due to the frequencies–rate of change of Earth’s equatorial ellipticity parameter and Earth’s rotation rate, and (ii) due to the frequencies–angular velocity of the bary-center around the sun and Earth’s rotation rate. Resonant curves are drawn where oscillatory amplitude becomes infinitely large at the resonant points. The effect of Earth’s equatorial ellipticity parameter …


Examining Bias Against Women In Professional Settings Through Bifurcation Theory, Lauren Cashdan Jan 2022

Examining Bias Against Women In Professional Settings Through Bifurcation Theory, Lauren Cashdan

CMC Senior Theses

When it comes to women in professional hierarchies, it is important to recognize the lack of representation at the higher levels. By modeling these situations we hope to draw attention to the issues currently plaguing professional atmospheres. In a paper by Clifton et. al. (2019), they model the fraction of women at any level in a professional hierarchy using the parameters of hiring gender bias and internal homophily on behalf of the applicant. This thesis will focus on a key theory in Clifton et. al.’s analysis and explain its role in the model, specifically bifrucation analysis. In order to analyze …


(R1493) Discussion On Stability And Hopf-Bifurcation Of An Infected Prey Under Refuge And Predator, Moulipriya Sarkar, Tapasi Das Dec 2021

(R1493) Discussion On Stability And Hopf-Bifurcation Of An Infected Prey Under Refuge And Predator, Moulipriya Sarkar, Tapasi Das

Applications and Applied Mathematics: An International Journal (AAM)

The paper deals with the case of non-selective predation in a partially infected prey-predator system, where both the susceptible prey and predator follow the law of logistic growth and some preys avoid predation by hiding. The disease-free preys get infected in due course of time by a certain rate. However, the carrying capacity of the predator population is considered proportional to the sum-total of the susceptible and infected prey. The positivity and boundedness of the solutions of the system are studied and the existence of the equilibrium points and stability of the system are analyzed at these points. The effect …


Qualitative Analysis Of A Modified Leslie-Gower Predator-Prey Model With Weak Allee Effect Ii, Manoj K. Singh, B. S. Bhadauria Jun 2021

Qualitative Analysis Of A Modified Leslie-Gower Predator-Prey Model With Weak Allee Effect Ii, Manoj K. Singh, B. S. Bhadauria

Applications and Applied Mathematics: An International Journal (AAM)

The article aims to study a modified Leslie-Gower predator-prey model with Allee effect II, affecting the functional response with the assumption that the extent to which the environment provides protection to both predator and prey is the same. The model has been studied analytically as well as numerically, including stability and bifurcation analysis. Compared with the predator-prey model without Allee effect, it is found that the weak Allee effect II can bring rich and complicated dynamics, such as the model undergoes to a series of bifurcations (Homoclinic, Hopf, Saddle-node and Bogdanov-Takens). The existence of Hopf bifurcation has been shown for …


Supercritical And Subcritical Pitchfork Bifurcations In A Buckling Problem For A Graphene Sheet Between Two Rigid Substrates, Jake Grdadolnik Jan 2021

Supercritical And Subcritical Pitchfork Bifurcations In A Buckling Problem For A Graphene Sheet Between Two Rigid Substrates, Jake Grdadolnik

Williams Honors College, Honors Research Projects

In this paper we study a model of the buckling of a sheet of graphene between two rigid substrates. We seek to understand the buckling of the sheet as the substrate separation is varied with a fixed load on each end of the sheet. We write down the expression for total energy of the system and from it derive a 2-point nonlinear boundary-value problem whose solutions are equilibrium configurations of the sheet. We cannot get an explicit solution. Instead, we perform a bifurcation analysis by using asymptotics to approximate solutions on the bifurcating branches near the bifurcation points. The bifurcating …


Stochastic Delay Differential Equations With Applications In Ecology And Epidemics, Hebatallah Jamil Alsakaji Nov 2020

Stochastic Delay Differential Equations With Applications In Ecology And Epidemics, Hebatallah Jamil Alsakaji

Dissertations

Mathematical modeling with delay differential equations (DDEs) is widely used for analysis and predictions in various areas of life sciences, such as population dynamics, epidemiology, immunology, physiology, and neural networks. The memory or time-delays, in these models, are related to the duration of certain hidden processes like the stages of the life cycle, the time between infection of a cell and the production of new viruses, the duration of the infectious period, the immune period, and so on. In ordinary differential equations (ODEs), the unknown state and its derivatives are evaluated at the same time instant. In DDEs, however, the …


Complexity Dynamics Of Gumowski-Mira Map, Sada Nand Prasad, K. R. Meena, Abdullah A. Ansari Jun 2020

Complexity Dynamics Of Gumowski-Mira Map, Sada Nand Prasad, K. R. Meena, Abdullah A. Ansari

Applications and Applied Mathematics: An International Journal (AAM)

In the context of nonlinear dynamics, interesting dynamic behavior of Gumowski-Mira Map has been noted under various feasible circumstances. Evolutionary phenomena are discussed through the study of bifurcation analysis leading to period-doubling and chaos. The appearance of chaos in the method is identified by plotting Lyapunov characteristic exponents (LCE) and Topological Entropy within certain parameter range. Dynamic Lyapunov Indicator (DLI) has been procured for further identification of regular and chaotic motions of the Gumowski-Mira Map. The numerical results through the indicator DLI clearly demonstrate the behavior of our map. The correlation dimension has been calculated numerically for the dimension of …


The Impact Of Nonlinear Harvesting On A Ratio-Dependent Holling-Tanner Predator-Prey System And Optimum Harvesting, Manoj Kumar Singh, B. S. Bhadauria Jun 2020

The Impact Of Nonlinear Harvesting On A Ratio-Dependent Holling-Tanner Predator-Prey System And Optimum Harvesting, Manoj Kumar Singh, B. S. Bhadauria

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, a Holling-Tanner predator-prey model with ratio-dependent functional response and non-linear prey harvesting is analyzed. The mathematical analysis of the model includes existence, uniqueness and boundedness of positive solutions. It also includes the permanence, local stability and bifurcation analysis of the model. The ratio-dependent model always has complex dynamics in the vicinity of the origin; the dynamical behaviors of the system in the vicinity of the origin have been studied by means of blow up transformation. The parametric conditions under which bionomic equilibrium point exist have been derived. Further, an optimal harvesting policy has been discussed by using …


The Long Time Behavior Of The Predator-Prey Model With Holling Type Iii, Regen S. Mcgee May 2020

The Long Time Behavior Of The Predator-Prey Model With Holling Type Iii, Regen S. Mcgee

Honors Theses

In this paper, the classical Lotka-Volterra model is expanded based on functional response of Holling type III to analyze a dynamical predator-prey relationship with hunting cooperation (a) and the Allee effect among predators. The stability of equilibrium solutions was first analyzed by deriving a Jacobian matrix from partial derivatives of our model. Newly derived eigenvalues are then used to determine the stability. The viability of the model is then demonstrated by using MATLAB. The numerical results show a clear Allee effect and a variety of possible phenomena related to stability when carrying capacity (k) is varied. Two different types of …


Mathematical Modelling Of The Tuberculosis Epidemiology, Ally Yeketi Ayinla Feb 2020

Mathematical Modelling Of The Tuberculosis Epidemiology, Ally Yeketi Ayinla

Student Works (2020-2029)

This project analyses the tuberculosis (TB) epidemic mathematically using compartmental modelling approach. Three models are presented to discuss drug susceptible and multi-drug resistant TB. The first model presented has 4 compartments; susceptible, exposed, infectious and recovered. The relevance of the exposed class in managing TB is analysed and found to be useful in delaying the eventual onset of the infection. Compared to previous researches, our results significantly show that when efforts are made such that no infected individual bypasses the exposed class and progresses directly to the infectious, the TB epidemic is successfully combatted. Also, the model is used to …


Qualitative Analysis Of A Modified Leslie-Gower Predator-Prey Model With Weak Allee Effect Ii, Manoj K. Singh, B. S. Bhadauria Jun 2019

Qualitative Analysis Of A Modified Leslie-Gower Predator-Prey Model With Weak Allee Effect Ii, Manoj K. Singh, B. S. Bhadauria

Applications and Applied Mathematics: An International Journal (AAM)

The article aims to study a modified Leslie-Gower predator-prey model with Allee effect II, affecting the functional response with the assumption that the extent to which the environment provides protection to both predator and prey is the same. The model has been studied analytically as well as numerically, including stability and bifurcation analysis. Compared with the predator-prey model without Allee effect, it is found that the weak Allee effect II can bring rich and complicated dynamics, such as the model undergoes to a series of bifurcations (Homoclinic, Hopf, Saddle-node and Bogdanov-Takens). The existence of Hopf bifurcation has been shown for …


Mathematically Modeling The Role Of Triglyceride Production On Leptin Resistance, Yu Zhao, Daniel Burkow, Baojun Song Jan 2019

Mathematically Modeling The Role Of Triglyceride Production On Leptin Resistance, Yu Zhao, Daniel Burkow, Baojun Song

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

Diet-induced obesity is becoming more common all over the world, which is increasing the prevalence of obesity-induced chronic diseases such as diabetes, coronary heart disease, cancer, and sleep apnea. Many experimental results show that obesity is often associated with an elevated concentration of plasma leptin and triglycerides. Triglycerides inhibit the passage of leptin across the blood–brain barrier (BBB) to signal the hypothalamus to suppress appetite. However, it is still not clear how triglyceride concentration affects leptin transport across the BBB and energy balance. In this paper, we propose a novel ordinary differential equations model describing the role of leptin in …


Hopf Bifurcation Analysis Of Chaotic Chemical Reactor Model, Daniel Mandragona Jan 2018

Hopf Bifurcation Analysis Of Chaotic Chemical Reactor Model, Daniel Mandragona

Honors Undergraduate Theses

Bifurcations in Huang's chaotic chemical reactor system leading from simple dynamics into chaotic regimes are considered. Following the linear stability analysis, the periodic orbit resulting from a Hopf bifurcation of any of the six fixed points is constructed analytically by the method of multiple scales across successively slower time scales, and its stability is then determined by the resulting final secularity condition. Furthermore, we run numerical simulations of our chemical reactor at a particular fixed point of interest, alongside a set of parameter values that forces our system to undergo Hopf bifurcation. These numerical simulations then verify our analysis of …


On The Existence Of Bogdanov-Takens Bifurcations, Zachary Deskin Dec 2017

On The Existence Of Bogdanov-Takens Bifurcations, Zachary Deskin

Graduate Theses/Dissertations

In bifurcation theory, there is a theorem (called Sotomayor's Theorem) which proves the existence of one of three possible bifurcations of a given system, provided that certain conditions of the system are satisfied. It turns out that there is a "similar" theorem for proving the existence of what is referred to as a Bogdanov-Takens bifurcation. The author is only aware of one reference that has the proof of this theorem. However, most of the details were left out of the proof. The contribution of this thesis is to provide the details of the proof on the existence of Bogdanov-Takens bifurcations.


A Study Of The Effect Of Harvesting On A Discrete System With Two Competing Species, Rebecca G. Clark Jan 2016

A Study Of The Effect Of Harvesting On A Discrete System With Two Competing Species, Rebecca G. Clark

Theses and Dissertations

This is a study of the effect of harvesting on a system with two competing species. The system is a Ricker-type model that extends the work done by Luis, Elaydi, and Oliveira to include the effect of harvesting on the system. We look at the uniform bound of the system as well as the isoclines and perform a stability analysis of the equilibrium points. We also look at the effects of harvesting on the stability of the system by looking at the bifurcation of the system with respect to harvesting.


The Effect Of Noise On The Response Of A Vertical Cantilever Beam Energy Harvester, Michael I. Friswell, Onur Bilgen, S. Faruque Ali, Grzegorz Litak, Sondipon Adhikari May 2015

The Effect Of Noise On The Response Of A Vertical Cantilever Beam Energy Harvester, Michael I. Friswell, Onur Bilgen, S. Faruque Ali, Grzegorz Litak, Sondipon Adhikari

Mechanical & Aerospace Engineering Faculty Publications

An energy harvesting concept has been proposed comprising a piezoelectric patch on a vertical cantilever beam with a tip mass. The cantilever beam is excited in the transverse direction at its base. This device is highly nonlinear with two potential wells for large tip masses, when the beam is buckled. For the pre-buckled case considered here, the stiffness is low and hence the displacement response is large, leading to multiple solutions to harmonic excitation that are exploited in the harvesting device. To maximise the energy harvested in systems with multiple solutions the higher amplitude response should be preferred. This paper …


Modeling Contagion In The Eurozone Crisis Via Dynamical Systems, Giuseppe Castellacci, Youngna Choi Jan 2015

Modeling Contagion In The Eurozone Crisis Via Dynamical Systems, Giuseppe Castellacci, Youngna Choi

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

We recently (Castellacci and Choi, 2013) formulated a theoretical framework for the modeling of financial instability contagion using the theories of dynamical systems. Here, our main goal is to model the Eurozone financial crisis within that framework. The underlying system comprises many economic agents that belong to several subsystems. In each instantiation of this framework, the hierarchy and nesting of the subsystems is dictated by the nature of the problem at hand. We describe in great detail how a suitable model can be set up for the Eurozone crisis. The dynamical system is defined by the evolution of the wealths …


Dynamics Of Phytoplankton, Zooplankton And Fishery Resource Model, B. Dubey, Atasi Patra, R. K. Upadhyay Jun 2014

Dynamics Of Phytoplankton, Zooplankton And Fishery Resource Model, B. Dubey, Atasi Patra, R. K. Upadhyay

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, a new mathematical model has been proposed and analyzed to study the interaction of phytoplankton- zooplankton-fish population in an aquatic environment with Holloing’s types II, III and IV functional responses. It is assumed that the growth rate of phytoplankton depends upon the constant level of nutrient and the fish population is harvested according to CPUE (catch per unit effort) hypothesis. Biological and bionomical equilibrium of the system has been investigated. Using Pontryagin’s Maximum Principal, the optimal harvesting policy is discussed. Chaotic nature and bifurcation analysis of the model system for a control parameter have been observed through …


Different Types Of Backward Bifurcations Due To Density-Dependent Treatments, Baojun Song, Wen Du, Jie Lou Oct 2013

Different Types Of Backward Bifurcations Due To Density-Dependent Treatments, Baojun Song, Wen Du, Jie Lou

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

A set of deterministic SIS models with density-dependent treatments are studied to understand the disease dynamics when different treatment strategies are applied. Qualitative analyses are carried out in terms of general treatment functions. It has become customary that a backward bifurcation leads to bistable dynamics. However, this study finds that finds that bistability may not be an option at all; the disease-free equilibrium could be globally stable when there is a backward bifurcation. Furthermore, when a backward bifurcation occurs, the fashion of bistability could be the coexistence of either dual stable equilibria or the disease-free equilibrium and a stable limit …


Uncertainty Quantification Of Film Cooling Effectiveness In Gas Turbines, Hessam Babaee Jan 2013

Uncertainty Quantification Of Film Cooling Effectiveness In Gas Turbines, Hessam Babaee

LSU Master's Theses

In this study the effect of uncertainty of velocity ratio on jet in crossflow and particual- rly film cooling performance is studied. Direct numerical simulations have been combined with a stochastic collocation approach where the parametric space is discretized using Multi-Element general Polynomial Chaos (ME-gPC) method. Velocity ratio serves as a bifurcation parameter in a jet in a crossflow and the dynamical system is shown to have several bifurcations. As a result of the bifurcations, the target functional is observed to have low-regularity with respect to the paramteric space. In that sense, ME-gPC is particularly effective in discretizing the parametric …


Coherent Pattern Prediction In Swarms Of Delay-Coupled Agents, Luis Mier-Y-Teran-Romero, Eric Forgoston, Ira B. Schwartz May 2012

Coherent Pattern Prediction In Swarms Of Delay-Coupled Agents, Luis Mier-Y-Teran-Romero, Eric Forgoston, Ira B. Schwartz

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

We consider a general swarm model of self-propelling agents interacting through a pairwise potential in the presence of noise and communication time delay. Previous work has shown that a communication time delay in the swarm induces a pattern bifurcation that depends on the size of the coupling amplitude. We extend these results by completely unfolding the bifurcation structure of the mean field approximation. Our analysis reveals a direct correspondence between the different dynamical behaviors found in different regions of the coupling-time delay plane with the different classes of simulated coherent swarm patterns. We derive the spatiotemporal scales of the swarm …


A Discrete Model Of Guided Modes And Anomalous Scattering In Periodic Structures, Natalia Grigoryevna Ptitsyna Jan 2009

A Discrete Model Of Guided Modes And Anomalous Scattering In Periodic Structures, Natalia Grigoryevna Ptitsyna

LSU Doctoral Dissertations

We study a discrete prototype of anomalous scattering associated with the interaction of guided modes of a periodic scatterer and plane waves incident upon the scatterer. The transmission anomalies arise because of the non-robustness of a guided mode, a mode that exists only at a specific frequency and wave number pair. The simplicity of the discrete prototype allows one to make certain explicit calculations and proofs, and to examine details of important resonant phenomena of the open wave guides. The main results are (1) a formula for transmission anomalies near a non-robust guided mode with rigorous error estimates that extends …


Mathematical Analysis Of The Transmission Dynamics Of Hiv/Tb Coinfection In The Presence Of Treatment, Oluwaseun Sharomi, Chandra N. Podder, Abba B. Gumel, Baojun Song Jan 2008

Mathematical Analysis Of The Transmission Dynamics Of Hiv/Tb Coinfection In The Presence Of Treatment, Oluwaseun Sharomi, Chandra N. Podder, Abba B. Gumel, Baojun Song

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

This paper addresses the synergistic interaction between HIV and mycobacterium tuberculosis using a deterministic model, which incorporates many of the essential biological and epidemiological features of the two diseases. In the absence of TB infection, the model (IIIV-only model) is shown to have a globally asymptotically stable, disease-free equilibrium whenever the associated reproduction number is less than unity and has a unique endemic equilibrium whenever this number exceeds unity. On the other hand, the model with TB alone (TB-only model) undergoes the phenomenon of backward bifurcation, where the stable disease-free equilibrium co-exists with a stable endemic equilibrium when the associated …


Raves, Clubs And Ecstasy: The Impact Of Peer Pressure, Baojun Song, Melissa Castillo-Garsow, Karen R. Ríos-Soto, Marcin Mejran, Leilani Henso, Carlos Castillo-Chavez Jan 2006

Raves, Clubs And Ecstasy: The Impact Of Peer Pressure, Baojun Song, Melissa Castillo-Garsow, Karen R. Ríos-Soto, Marcin Mejran, Leilani Henso, Carlos Castillo-Chavez

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

Ecstasy has gained popularity among young adults who frequent raves and nightclubs. The Drug Enforcement Administration reported a 500 percent increase in the use of ecstasy between 1993 and 1998. The number of ecstasy users kept growing until 2002, years after a national public education initiative against ecstasy use was launched. In this study, a system of differential equations is used to model the peer-driven dynamics of ecstasy use. It is found that backward bifurcations describe situations when sufficient peer pressure can cause an epidemic of ecstasy use. Furthermore, factors that have the greatest influence on ecstasy use as predicted …


A Logistic Model Of Periodic Chemotherapy, J. C. Panetta Jan 1995

A Logistic Model Of Periodic Chemotherapy, J. C. Panetta

Mathematics & Statistics Faculty Publications

A logistic differential equation with a time-varying periodic parameter is used to model the growth of cells, in particular cancer cells, in the presences of chemotherapeutic drugs. The chemotherapeutic effects are modeled by a periodic parameter that modifies the growth rate of the cell tissue. A negative growth rate represents the detrimental effects of the drugs. A simple criterion is obtained for the behavior of the chemotherapy.