Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Physical Sciences and Mathematics
Biomimetic Tools In Oxidative Metabolism: Characterization Of Reactive Metabolites From Antithyroid Drugs, Kudzanai Chipiso
Biomimetic Tools In Oxidative Metabolism: Characterization Of Reactive Metabolites From Antithyroid Drugs, Kudzanai Chipiso
Dissertations and Theses
Toxicities of sulfur-based drugs have been attributed to formation of highly reactive sulfur oxo-acids and depletion of glutathione by the formation of reactive metabolites. Metabolic activation of these sulfur centers to conceivably toxic reactive metabolites (RMs) that can covalently modify proteins is considered the initial step in drug-induced toxicity. Despite considerable effort and research, detection and characterization of these RMs during drug development and therapy remains a challenge. Methimazole (MMI) and 6-propyl-2-thiouracil (PTU) are two commonly used antithyroid, sulfur-based drugs. Though effective, these drugs are associated with idiosyncratic toxicity. PTU has acquired a black box warning and physicians are calling …
Peroxynitrite Chemistry: Formation, Decomposition And Possible Deactivation Mechanisms By Thiols, Olufunke Modupe Olagunju
Peroxynitrite Chemistry: Formation, Decomposition And Possible Deactivation Mechanisms By Thiols, Olufunke Modupe Olagunju
Dissertations and Theses
Kinetics of formation and decomposition of peroxynitrite was studied in acidic and buffer solutions. Peroxynitrous acid was formed in acidic media by the reaction of H2O2 with HNO2 and NO +. Bimolecular rate constant for reaction of H2O2 with HNO2 at 25°C was determined to be 3.7 × 10 3 M-1 s-1. Peroxynitrous acid formed is highly unstable with half life of approximately 1 second. Decomposition of peroxynitrite is highly pH-dependent. In acidic media, peroxynitrous acid decomposes to nitrate while at neutral to slightly basic media, products of decomposition …
Surface Area Of Coal As Influenced By Low Temperature Oxidation Processes, Salvador Leon Arredondo
Surface Area Of Coal As Influenced By Low Temperature Oxidation Processes, Salvador Leon Arredondo
Dissertations and Theses
The possibility of increasing the amount of readily accessible surface area by enlarging the 5 A pore was examined via pretreating the PSOC-371 coal with gases such as nitrogen, nitrogen-oxygen, and ozone-oxygen and hydrogen peroxide solutions. Surface areas were obtained from nitrogen adsorption at 77 K and carbon dioxide adsorption at either 298 or 195 K for each sample before and after treatment.