Physical Sciences and Mathematics Commons^™

Efficacy Analysis In Clinical Trials: A Comprehensive Review Of Statistical And Machine Learning Approaches, Dhrubajyoti Ghosh, Samhita Pal

Faculty Articles

Efficacy testing is a cornerstone of clinical trials, ensuring that medical interventions achieve their intended therapeutic effects. Over the decades, a wide range of statistical methodologies have been developed to address the complexities of clinical trial data, including parametric, nonparametric, Bayesian, and machine learning approaches. Parametric methods, such as t-tests, ANOVA, and LMMs, have traditionally been the foundation of efficacy testing due to their efficiency under well-defined assumptions. Nonparametric techniques, including the Friedman test, Brunner-Munzel test, and modern extensions like nparLD, have emerged as robust alternatives, particularly for skewed, ordinal, or non-normal data. Bayesian methodologies have enabled the incorporation of …

Rethinking News Classification Through A Multi-Dimensional Framework, Luana De Jesus Ferreira

Honors Theses

This thesis proposes a multi-dimensional framework for news classification that evaluates articles across three independent dimensions: headline accuracy, language neutrality, and content reliability. These dimensions produce both a continuous reliability score and a five-tier interpretive scale, while additionally classifying articles by genre and topic. To operationalize this framework, a structured annotation protocol was developed and applied to a dataset of 373 news articles drawn from 79 outlets spanning a wide range of contemporary media ecosystem. A binary Logistic Regression classifier trained on the ISOT Fake News Dataset was then evaluated against this dataset to examine how a model trained on …

Machine Learning And Multisensor Data Fusion For Forest Above Ground Biomass Estimation In Arkansas, Abdullah Al Saim, Mohamed Aly

Geosciences Faculty Publications and Presentations

Forests are essential for biodiversity conservation, climate change, natural education, scientific research, and carbon sequestration. This study uses machine learning-based Random Forest (RF) regression to estimate the Above Ground Biomass (AGB) of the Ozark and Ouachita forests at a 10-meter resolution by combining data from Sentinel-2, Sentinel-1, and GEDI (Global Ecosystem Dynamics Investigation) on Google Earth Engine. The RF model included 34 out of 154 variables representing topographical, spectral, and textural factors demonstrating strong correlations with measured biomass. The RF model showed strong performance with R-squared and RMSE values of 0.95 and 18.46 for the training dataset and 0.75 and …

Pushing High-Performance Private Inference Towards Resource-Constrained Edge Clients, Xiangrui Xu

Computer Science Theses & Dissertations

The widespread adoption of Machine Learning as a Service (MLaaS) has enabled resource constrained edge clients, such as mobile and IoT devices, to leverage powerful deep learning mod els hosted on the cloud. However, this paradigm introduces critical privacy challenges regarding the client’s sensitive input data and the server’s proprietary model parameters. While cryptographic techniques like Homomorphic Encryption (HE) and Multi-Party Computation (MPC) enable Private Inference (PI), existing frameworks impose prohibitive computational and communication overheads that render them impractical for edge deployment. This dissertation introduces three novel frameworks—SPOT, LUTless, and PrivShap—to systematically address the efficiency bottlenecks of PI in edge …

Addressing The Problems Of Data Variations, Quality, And Scarcity In Training Deep Neural Networks, Jian Sun

Electronic Theses and Dissertations

The performance of deep neural networks (DNNs) is strongly influenced by the characteristics and quality of the underlying datasets. This Ph.D. dissertation addresses three pervasive data challenges-imbalance, quality degradation, and scarcity-that commonly hinder the effectiveness of DNNs in computer vision (CV) and natural language processing (NLP) applications.

Class imbalance remains one of the most frequent causes of degraded model generalization. While Focal Loss effectively mitigates inter-class imbalance by assigning higher weights to minority classes, it struggles with intra-class imbalance, particularly in video datasets where longer clips dominate feature representation. To address this, I implement and utilize …

Clinical Prediction Of Posttreatment Migraine Recurrence Using Biofeedback Data: A Machine Learning Framework For Enhanced Patient Stratification And Treatment Monitoring, Shibbir Ahmed Arif, Ferdib-Al-Islam, Mehidy Hasan Sium

School of Computing Faculty Scholarship and Creative Works

Migraine is a complex neurological disorder with significant implications for individual well-being and public health. Predicting migraine occurrences after treatment is crucial for evaluating therapeutic efficacy and enabling personalized care, yet remains largely underexplored. This study proposes a robust machine learning framework to predict posttreatment migraine headache occurrences using real-world headache log data collected from 133 patients undergoing biofeedback therapy. The methodology includes rigorous data preprocessing, outlier removal via the interquartile range (IQR) method, and class imbalance correction through the synthetic minority oversampling technique (SMOTE). A total of 10 classical and a hybrid ensemble machine learning models were developed and …

Evolving Solutions For Red Blood Cell Preservation, Ali Alkafaji, Charles A. Elder, Mohammad Zaidi, Kavin Parthiv, Michael A. Menze

The Cardinal Edge

In emergencies such as natural disasters, armed conflicts, or during outer space missions, the availability of transfusable blood can mean the difference between life and death. Red blood cells (RBCs) must be stored at +4 ± 2 °C and have a shelf life of just 42 days, which makes maintaining a stable blood supply during adverse conditions extraordinarily challenging. This challenge was especially apparent during the COVID-19 pandemic when hospitals faced severe blood shortages. Freeze-drying, or lyophilization, offers a promising avenue to extend the shelf life of RBCs for transfusion during crises. However, a significant hurdle in dry preservation is …

Automated Machine Learning For High-Resolution Daily And Hourly Methane Emission Mapping For Rice Paddies Over South Korea: Integrating Modis, Era5-Land, And Soil Data, Jiah Jang, Seung Hee Kim, Menas Kafatos, Jaeil Cho, Gayoung Yoo, Sujong Jeong, Yangwon Lee

Institute for ECHO Articles and Research

Agriculture is a major global source of methane (CH4), and accurate emission estimates are essential for refining national greenhouse gas inventories and supporting climate-resilient policies. This study develops a high-resolution estimation framework for CH4 emissions from Korean rice paddies by integrating multi-source datasets, including Moderate Resolution Imaging Spectroradiometer (MODIS) vegetation indices, European Centre for Medium-Range Weather Forecasts (ECMWF) Reanalysis Version 5 (ERA5)-Land meteorological variables, and Harmonized World Soil Database (HWSD) soil properties. Using CH4 flux observations from four global rice ecosystems (Italy, Japan, South Korea, and USA), we constructed parallel daily and hourly machine learning models using an automated machine …

Improving Public Transport Through Machine Learning Influence Flow Analysis (Mifa): Southern England Bus Case Study, Benjamin Lee, Wolfgang Garn, Masoud Fakhimi, Nick F. Ryman-Tubb

Research Collection School Of Accountancy

Public transport (PT) is crucial for enhancing the quality of life and enabling sustainable urban development. As part of the UK Transport Investment Strategy, increasing PT usage is critical to achieving efficient and sustainable mobility. This paper introduces Machine Learning Influence Flow Analysis (MIFA), a novel framework for identifying the key influencers of PT usage. Using survey data from bus passengers in Southern England, we evaluate machine learning models. Subsequently, MIFA uncovers that easy payments, e-ticketing, and mobile applications can substantially improve the PT service. MIFA’s implementation demonstrates that strength and importance lead to specific insights into how service characteristics …

Deep Learning Approaches For Anti-Money Laundering On Mobile Transactions: Review, Framework, And Directions, Jiani Fan, Lwin Khin Shar, Ruichen Zhang, Ziyao Liu, Wenzhuo Yang, Dusit Niyato, Kwok-Yan Lam

Research Collection School Of Computing and Information Systems

Money laundering is a financial crime that obscures the origin of illicit funds, necessitating the development and enforcement of anti-money laundering (AML) policies by governments and organizations. The proliferation of mobile payment platforms and smart IoT devices has significantly complicated AML investigations. As payment networks become more interconnected, there is an increasing need for efficient real-time detection to process large volumes of transaction data on heterogeneous payment systems by different operators such as digital currencies, cryptocurrencies, and account-based payments. Most of these mobile payment networks are supported by connected devices, many of which are considered loT devices in the FinTech …

Uranium Chemical Compound Classification Using Sub-Images And Statistical Machine Learning For Nuclear Forensics, Lee C. Lambert, Brett J. Borghetti, Abigail A. Bickley

Faculty Publications

Uranium particle analysis from Scanning Electron Microscope (SEM) imagery is a crucial tool in nuclear forensics. The particle morphology lexicon proposed by Tamasi et al. in J Radioanal Nucl Chem 307, 1611–1619 (2016) follows a standardized, manual identification process to identify particle morphology features. The present work seeks to mirror this methodology using computer feature selection from the scikit-image Python library rather than human classification. Using a random forest classifier, a 56% overall uranium true positive classification accuracy (a 39.6% balanced classification accuracy) was achieved on a test set outperforming a naïve (chance) model by 48%. The methodology introduced splits …

Hybrid 3d Modelling Framework For Indoor Navigation Using Federated Learning And Internet Of Things-Enabled Edge Devices, Noopur Tyagi, Jaiteg Singh, Saravjeet Singh, Ahmad Ali Alzubi, Farman Ali, Sukhjit Singh Sehra, Babar Shah

All Works

Background There has been a recent trend towards using three-dimensional (3D) models to enhance spatial awareness and maximize resource utilization in complex environments. 3D building model can be used in various applications, such as real-time guidance and tracking the positions of individuals in multi storied buildings. Cities are now being modeled and studied in three dimensions as an improved method of urban planning. Method This study proposes an advanced indoor navigation framework that combines 3D modelling, federated learning (FL), and Internet of Things (IoT) integration to deliver reliable floor-level localization and real-time guidance. In Phase 1, highly accurate 3D models …

An Ai Approach To Lunar Phase Detection: Enhancing The Identification Of The New Crescent With Astronomical Data Integration, Murad Al-Rajab, Samia Loucif, Raed Abu Zitar, Mubarak Gwaza Abdu-Aguye

All Works

Introduction: The observation of the lunar crescent is significant in astronomy, cultural traditions, and religious lunar calendar determinations. However, earth-based imaging that captures all lunar phases, particularly the new crescent across multiple months, remains limited. This study explores the feasibility of using artificial intelligence (AI) techniques to detect and analyze the birth of the new lunar crescent using space-borne imagery from NASA’s Lunar Reconnaissance Orbiter (LRO), spanning over 13 years. Methods: This study evaluates both deep learning and traditional machine learning approaches for new crescent detection. Convolutional Neural Networks (CNN), Random Forests (RF), and Support Vector Machines (SVM) were applied …

Flaplet: A Full-Stack Web Platform For End-To-End Time Series Data Processing And Machine Learning In Solar Flare Prediction, Mohammadreza Eskandarinasab, Shah Muhammad Hamdi, Soukaina Filali Boubrahimi

Computer Science Student Research

Solar flare prediction is a central challenge in space weather forecasting, with direct implications for satellite operations, aviation safety, and power grid reliability. Machine learning has achieved state-of-the-art performance for this task, particularly when applied to photospheric magnetic field parameters. FlaPLeT is an open-source, full-stack web platform that supports end-to-end machine learning workflows for multivariate time-series–based solar flare prediction without requiring any coding expertise. Built with React, Django, Celery, and PostgreSQL, the system integrates dataset preprocessing, data augmentation, functional network (graph) construction, and machine learning model training into modular asynchronous tasks that generate downloadable datasets, trained models, and structured JSON …

Hybrid Data-Driven Cement-Stabilized Soil Design: An Integration Of Machine Learning, Multi-Objective Optimization, And Life Cycle Assessment, Chikezie Chimere Onyekwena, Yunli Li, Ikenna J. Okeke, Ubani Obinna Uzodimma, Monday Uchenna Okoronkwo, Wenping Wu

Chemical and Biochemical Engineering Faculty Research & Creative Works

Soil stabilization is crucial in geotechnical engineering, yet conventional methods are often time-consuming, resource-intensive, and environmentally unsustainable. Despite growing interest in Machine Learning (ML) and optimization tools for mix design, few studies integrate these methods with decision-making techniques and environmental assessment to support practical implementation. This study proposes a hybrid data-driven framework for predicting strength, optimizing mix compositions, and evaluating environmental impacts via life cycle assessment of cement-stabilized soft soils. Six ML models were evaluated, and the top-performing eXtreme Gradient Boosting (XGB) model was further improved using the Grey Wolf Optimizer (GWO). The optimized XGB-GWO model, integrated with a polynomial …

Machine Learning In Peak Demand Forecasting: Foundations, Trends, And Insights, Shuang Dai, Fanlin Meng, Hongsheng Dai, Qian Wang, Xizhong Chen, Wenlei Bai, Peizhi Shi, Richard Allmendinger, Yuchen Zhang, Jian Liu

Electrical and Computer Engineering Faculty Research & Creative Works

Peak demand forecasting involves predicting the maximum electricity demand within a specific period, which plays a key role in maintaining the efficiency and stability of power systems. The rapid evolution of power systems, driven by advanced metering infrastructure, local energy applications such as electric vehicles, and the increasing adoption of intermittent renewable energy, has introduced greater randomness and reduced predictability in peak demand. Given the pressing need to address more diverse implementation requirements across different contexts, accurate and reliable peak demand forecasting has become increasingly important. To the best of our knowledge, this study is the first to provide a …

Cellscout: Visual Analytics For Mining Biomarkers In Cell State Discovery, Rui Sheng, Zelin Zang, Jiachen Wang, Yan Luo, Zixin Chen, Yan Zhou, Shaolun Ruan, Huamin Qu

Research Collection School Of Computing and Information Systems

Cell state discovery is crucial for understanding biological systems and enhancing medical outcomes. A key aspect of this process is identifying distinct biomarkers that define specific cell states. However, difficulties arise from the co-discovery process of cell states and biomarkers: biologists often use dimensionality reduction to visualize cells in a two-dimensional space. Then they usually interpret visually clustered cells as distinct states, from which they seek to identify unique biomarkers. However, this assumption is often this assumption often fails to hold due to internal inconsistencies in a cluster, making the process trial-and-error and highly uncertain. Therefore, biologists urgently need effective …

Xgboost-Powered Predictive Analytics For Early Identification Of Thermal Runaway In Lithium-Ion Batteries, Isslam Alhasan, Mohd H.S. Alrashdan

All Works

Lithium-ion batteries are pivotal in powering modern technology, from electric vehicles to portable electronics. However, their safety is challenged by the risk of thermal runaway, a critical failure mode leading to catastrophic consequences such as fires and explosions. This study presents a machine learning framework for the early detection of thermal runaway events using sensor data from over 210 open-source battery tests. The framework utilizes voltage, temperature, and force measurements from experimental mechanical indentation tests, with force data providing additional predictive value beyond standard BMS sensors. Key features such as the rate of temperature change and voltage change were engineered …

Ai-Driven Automatic Fault Detection Systems: Revolutionizing Modern Smart Grids, Aravind Sanikommu

Student Theses and Dissertations

The increasing complexity of current power systems, resulting from the integration of distributed generators and renewable energy sources, necessitates intelligent and adaptive fault detection schemes. Traditional protection using impedance and phasor analysis is usually weak when operating in nonlinear and transient operating conditions. Consequently, the tools of Data-driven fault classification and decision-making have gained strength under artificial intelligence (AI) and machine learning (ML) to improve grid reliability. This thesis is a proposal of an automatic fault detection and classification system based on AI applied to a smart mini-grid setting built in MATLAB/Simulink. A complete set of voltage and current data …

Improving Rail System Signaling Efficiency Through Ai-Based Driving Profile Generation: A Comparative Performance Analysis, Mehmet Taci̇ddi̇n Akçay, Abdurrahi̇m Akgündoğdu

Turkish Journal of Electrical Engineering and Computer Sciences

In this study, a dataset comprising 3600 discrete operational snapshots (rather than continuous time-series data) derived from real-field operations is used to obtain a high-accuracy driving profile equation using a second-degree Polynomial Regression method. This equation demonstrates the model’s interpretability. The performance metrics obtained with the second-degree polynomial regression model’s equation are as follows: a coefficient of determination (R2) of 0.84, a Pearson Correlation Coefficient of 0.91, and an RMSE of 11.13. These results indicate the effectiveness of artificial intelligence-based approaches in improving the efficiency of the railway signaling system. The same dataset is also utilized with other machine learning …

Utilizing Machine Learning Techniques For Computer-Aided Covid-19 Screening Based On Clinical Data, Honglun Xu, Andrews T. Anum, Michael Pokojovy, Sreenath Chalil Madathil, Yuxin Wen, Md. Fashiar Rahman, Tzu-Liang Bill Tseng, Scott Moen, Eric Walser

Engineering Faculty Articles and Research

The COVID-19 pandemic has highlighted the importance of rapid clinical decision-making to facilitate the efficient usage of healthcare resources. Over the past decade, machine learning (ML) has caused a tectonic shift in healthcare, empowering data-driven prediction and decision-making. Recent research demonstrates how ML was used to respond to the COVID-19 pandemic. This paper puts forth new computer-aided COVID-19 disease screening techniques using six classes of ML algorithms (including penalized logistic regression, random forest, artificial neural networks, and support vector machines) and evaluates their performance when applied to a real-world clinical dataset containing patients’ demographic information and vital indices (such as …

Optimizing Proaftn Classifier With Ant Colony Algorithm: Enhanced Diabetes Detection Benchmarking, Feras Al-Obeidat

All Works

The increasing global prevalence of diabetes highlights the need for accurate diagnostic tools to improve early detection and effective treatment planning. Traditional classification models often struggle to achieve optimal performance due to limitations in parameter tuning and adaptability to complex datasets. To address these limitations, this article introduces PROAnt, an innovative learning approach designed to enhance the robustness and efficiency of the PROAFTN multicriteria classification method. PROAnt leverages the computational power of ant colony optimization (ACO) to dynamically fine-tune and optimize the key parameters, such as intervals and weights, at the core of the PROAFTN classification process. This learning methodology …

A Visualization-Supported, Hierarchical, Action-Learning Model For Driving Behavior In A V2x Environment, Xuantong Wang, Jing Li, Jecca Bowen

Geography and the Environment: Faculty Scholarship

Understanding human driving decisions is crucial for intelligent transportation research. Most existing studies focus on individual vehicles in limited contexts, which restricts broader applicability of results. Leveraging Vehicle-to-Everything (V2X) infrastructure, this study introduces a machine learning framework to model driving actions and detect outliers across diverse environments. This approach features a semantically enabled clustering method that groups similar driving behaviors based on speed and actions. It also adds a time-series learning model to identify typical driving behaviors across various contexts, thereby enabling detection of abnormal driving actions. A suite of visual tools has been developed to help interpret driving patterns, …

Timing, Orbital Pacing, And Provenance Of Late Paleogene Loess In The Western United States, Xiangwei Guo

Earth & Environmental Sciences Dissertations - Archive

This project examines the timing of loess emergence, the nature of the fluvial–eolian transition, orbital forcing on dust accumulation, and sediment recycling in the late Paleogene White River Formation (Group) of Wyoming and Nebraska, western United States. By integrating traditional sedimentology with machine learning–enhanced grain-size analysis, this research shows that loess accumulation at Flagstaff Rim in central Wyoming began during active fluvial deposition at approximately 35.8 Ma, indicating a gradual transition from fluvial to eolian conditions. Machine learning complements field sedimentology and granulometric interpretation while enabling the development of new, testable hypotheses. Extending this framework eastward to Toadstool Geologic Park …

Ai For Life Sciences: From Geometric Protein Modeling To Multimodal Drug Design, Feng Jiang

Computer Science and Engineering Dissertations

Predicting biomolecular interactions, from immune recognition to drug–target binding, is a central problem in the life sciences and computational drug discovery. Deep learning has advanced this area, yet three challenges persist: the topology of large, highly imbalanced interaction networks; structural noise in computationally predicted protein models; and the integration of multimodal information such as functional text and taxonomic annotations. This dissertation develops a coherent set of models spanning immune complex prediction and small-molecule drug design: graph learning that addresses network topology and severe class imbalance; a noise-tolerant method that fuses predicted structures with evolutionary sequence features; and multimodal representation learning …

Comparative Machine Learning Models For Disease Risk Prediction, Mercy Mawusi Agbley

Theses, Dissertations and Capstones

Accurate prediction of disease outcomes is crucial for improving clinical decision-making and enabling early intervention. This study compares the performance of various statistical and machine learning models for clinical risk prediction using two healthcare datasets: diabetic retinopathy and heart disease. The models assessed include Logistic Regression, LASSO, k-Nearest Neighbors (KNN), Support Vector Machines (SVM), Neural Networks, Random Forests, Gradient Boosting Machines (GBM), and a stacked ensemble model. Prior to modeling, datasets were split into train and test sets. Standardization was applied to numeric features whilst categorical features were one-hot encoded. These transformations were later applied to the test set. Principal …

A Hybrid Response Surface Methodology And Machine Learning Framework For Quantifying Effects Of Physicochemical Parameters On Pfas Distribution, Harsh V. Patel, Jazmin Green, Hyoshin Park, Stephanie Luster-Teasley Pass, Renzun Zhao

Engineering Management & Systems Engineering Faculty Publications

Predicting PFAS adsorption across diverse adsorbents and environmental matrices remains challenging because adsorbent physicochemical properties, PFAS molecular descriptors, and operational conditions simultaneously influence adsorption. This study develops and evaluates a unified hybrid modeling framework that integrates Response Surface Model (RSM) with machine-learning algorithms to quantify how six key variables, surface area, Log K_ow, pH_pzc, pK_a, log dose, and log-initial concentration, affect PFAS distribution coefficients (Log K_d). A data set of more than 1000 adsorption observations spanning 15 PFAS compounds, multiple adsorbent types, and a broad operational range was compiled and preprocessed using …

Serum Biomarker Trajectory Clusters Predict Functional Outcome And Quality Of Life For Traumatic Brain Injury, Thanh Son Do, Chantal Carnes, Zhihui Yang, Firas Kobeissy, Hamad Yadikar, Gayla R. Olbricht, Olli Tenovuo, Jussi P. Posti, Ewout W. Steyerberg, Lindsay Wilson, Nicole Von Steinbüchel, Endre Czeiter, Andras Buki, David K. Menon

Mathematics and Statistics Faculty Research & Creative Works

Serum brain-enriched biomarkers are increasingly employed in the clinical evaluation of traumatic brain injury (TBI) to assist with triage, neuroimaging decisions, and prognostication. However, the potential of temporal biomarker trajectories to inform disease monitoring and long-term outcomes remains underexplored. We aim to identify distinct biomarker trajectory (TRAJ) profiles in traumatic brain injury patients and to examine their associations with long-term clinical outcomes. The study included 373, CT-positive Intensive Care Unit (ICU) traumatic brain injury patients (256 with initial Glasgow Coma Scale 3–12) from the Collaborative European Neurotrauma Effectiveness Research in TBI (CENTER-TBI) core study who had at least two serum …

Cybersecurity Center For Offshore Wind Energy (Final Project Round), Sachin Shetty

Center for Secure and Intelligent Critical Systems (CSICS) Publications

This project establishes a Cybersecurity Center for Offshore Wind Energy with the objective of designing and operating a cyber-physical testbed for wind energy farms (WEFs) that enables comprehensive cybersecurity research. The testbed incorporates a Supervisory Control and Data Acquisition (SCADA) system connected to turbine models via industrial-grade programmable logic controllers (PLCs) and remote terminal units (RTUs). It supports side-channel data acquisition, implementation and analysis of various cyberattack scenarios, and development of attack detection, mitigation, and best-practice guidance tailored to wind energy systems. During the project, the team expanded the number and fidelity of mathematical turbine models (MTMs), integrated these models …

Ordered Mini-Batch Training For Differentially Private And Encrypted Logistic Regression, Ryan Leone

Theses, Dissertations and Culminating Projects

Logistic regression has found extensive use as a supervised machine learning algorithm due to its simplicity and efficiency in binary and multivariate classification tasks. As data sharing grows across connected devices, safeguarding sensitive personal and industrial information is of increased importance. Privacy-preserving machine learning techniques such as differential privacy and homomorphic encryption offer mathematically rigorous security guarantees, but introduce difficult accuracy, privacy loss, and computational overhead issues. This thesis investigates PPML for logistic regression through a collaborative mini-batch training framework. I propose and implement an ordered mini-batch strategy, compare it to standard shuffled methods, then integrate differential privacy noise injection …