Open Access. Powered by Scholars. Published by Universities.®

Physical Sciences and Mathematics Commons

Open Access. Powered by Scholars. Published by Universities.®

Health and environmental sciences

Discipline
Institution
Publication Year
Publication
Publication Type

Articles 1 - 30 of 104

Full-Text Articles in Physical Sciences and Mathematics

Effects Of Elevated Temperature On Gonadal Functions, Cellular Apoptosis, And Oxidative Stress In Atlantic Sea Urchin (Arbacia Punctulata), Jackson B. Johnstone May 2019

Effects Of Elevated Temperature On Gonadal Functions, Cellular Apoptosis, And Oxidative Stress In Atlantic Sea Urchin (Arbacia Punctulata), Jackson B. Johnstone

Theses and Dissertations

Increasing surface sea water temperatures effect on growth, reproduction and development in marine organisms. Sea urchins are excellent indicator species and ideal model organisms to focus on. In this study, I tested the effect of higher temperatures on reproductive functions, heat shock protein (HSP, a chaperone protein produced by cells in response to heat stress) and nitrotyrosine protein (NTP, an indicator of reactive nitrogen species, RNS) expressions, cellular apoptosis, and ceolomic fluid (CF, a body fluid which regulates important physiological processes) conditions in Atlantic sea urchin at three different temperatures. Ten sea urchins were placed in each of six aquariums …


Effects Of Global Warming On Gonadal Functions, Cellular Apoptosis, And Oxidative Stress In The American Oyster, Sarah B. Nash May 2019

Effects Of Global Warming On Gonadal Functions, Cellular Apoptosis, And Oxidative Stress In The American Oyster, Sarah B. Nash

Theses and Dissertations

Global warming due to climate change is predicted to intensify the heat stress in marine and coastal organisms, affecting their development, growth and reproductive functions. In this study. I analyzed gonadal development, heat shock protein 70 (HSP70), nitrotyrosine protein (NTP), dinitrophenyl (DNP) expressions, cellular apoptosis, and coelomic fluid (CF) conditions in American oyster. Oysters were placed in six aquariums and exposed to control (24°C), medium (28°C), and high (32°C) temperatures for one week. Higher temperature significantly decreased the number of eggs and sperm. CF protein concentrations also declined compared to control. In contrast, CF pH and HSP70 expression in gonad …


A Snapshot Of The Age, Growth, And Reproductive Status Of Gray Triggerfish (Balistes Capriscus, Gmelin 1789) On Three Artificial Reefs In The Northwest Gulf Of Mexico, Adam M. Lee May 2019

A Snapshot Of The Age, Growth, And Reproductive Status Of Gray Triggerfish (Balistes Capriscus, Gmelin 1789) On Three Artificial Reefs In The Northwest Gulf Of Mexico, Adam M. Lee

Theses and Dissertations

Age, growth, and reproductive status of gray triggerfish (Balistes capriscus) were identified from 2015-2016 on artificial reefs in the northwest Gulf of Mexico. Individuals ranged from 232-432 mm fork length with and a mean fork length of 319 mm. Individuals from age 0.2 to 5.2 yrs were observed with a weight to length relationship of Wg = 1.1 x -104 x FL2.7 (r2 = 0.94, n = 112), where FL = fork length (mm) and Wg = weight (g). A von Bertalanffy growth equation of Lt = 326(1 - e - 0.9 (t + 1.71)) was calculated irrespective …


Measuring Connective Capacity Throughout The Gulf Of Mexico Fishery Management Network, Anthony Rocha Lima Dec 2018

Measuring Connective Capacity Throughout The Gulf Of Mexico Fishery Management Network, Anthony Rocha Lima

Theses and Dissertations

The Gulf of Mexico provides substantial resources along its 1,680-mile coastline, spanning 5 U.S. states and providing millions of pounds of seafood and hundreds of millions in revenue annually. Continued success of the fishery relies on the ability of a large, complex, multiagency network to find the best solutions to balance the needs of humans, as well as ensure long-term sustainability. Organizations with varying objectives require effective communication when addressing intricate ecosystem-based management topics such as endangered species and regional economies.

To better understand the connectivity within the Gulf fishery management network, an IRB reviewed survey was dispersed to the …


Longitudinal And Temporal Comparison Of Beach Sand On The Rio Grande Delta System, Samantha B. Moore Dec 2018

Longitudinal And Temporal Comparison Of Beach Sand On The Rio Grande Delta System, Samantha B. Moore

Theses and Dissertations

The Rio Grande is the 5th longest river in North America and defines a significant extent of the United States-Mexico border. It extends for 2830 km from its headwaters in the Rocky Mountains of Colorado to the Gulf of Mexico. The Rio Grande is fed by streams from the Sangre de Cristo Mountains, the Rio Conchos, the Pecos River, runoff from the Sacramento Mountains area, Devils River, the Rio Salado, and the Rio San Juan. This study addresses how the composition of sand forming the Rio Grande river delta into the Gulf of Mexico at Boca Chica Beach is changed …


Impacts Of Habitat Attributes And Community Gardens On Urban Bird Communities, Samuel Glenn Ortiz Dec 2018

Impacts Of Habitat Attributes And Community Gardens On Urban Bird Communities, Samuel Glenn Ortiz

Theses and Dissertations

The Rio Grande Valley of Southern Texas is a major agricultural region yet has some of the highest hunger rates in the USA. Urbanization and agriculture affect biodiversity, which is well studied, but little is known about how agriculture affects biodiversity in urban areas. We investigated how different urban attributes, including those related to urban farming, impact bird communities in Brownsville and Harlingen, TX, and compared sites that have community gardens to those that do not. To study three key urban habitat characteristics, we identified sites that exhibited all possible combinations of these factors, quantified land cover classes related to …


Characterizing Polychlorinated Biphenyl Degradation Potential In Surface Water Bacteria From Rio Grande Valley, Texas Reservoirs, Alisha M. Janiga Aug 2018

Characterizing Polychlorinated Biphenyl Degradation Potential In Surface Water Bacteria From Rio Grande Valley, Texas Reservoirs, Alisha M. Janiga

Theses and Dissertations

The Donna Reservoir in Donna, Texas is contaminated with polychlorinated biphenyl (PCB) pollution. This reviews the current understanding of PCBs and investigate the potential of PCB degradation by native bacteria communities in the Donna Reservoir. The metabolic diversity, biphenyl tolerance, bphA1 presence were tested on surface water samples from the Donna Reservoir. The Ecoplate data suggest that the communities have a diverse metabolic capacity and the degree of plant life may interact with carbon type metabolism but not the rate of growth. Biphenyl growth curves showed that all the samples from the Donna Reservoir are tolerant to the average PCB …


Removal Of Chromium(Vi) And Chromium(Iii) Ions From Aqueous Solution Using Bio-Char Generated From Agricultural Waste Products, Diego Fernando Gonzalez May 2018

Removal Of Chromium(Vi) And Chromium(Iii) Ions From Aqueous Solution Using Bio-Char Generated From Agricultural Waste Products, Diego Fernando Gonzalez

Theses and Dissertations

Heavy metals are one of the most persistent and prevalent contaminants in the aquatic environment. The removal of chromium from aqueous solution, especially in the hexavalent form is difficult. New technologies, techniques and/or new materials have been designed in order to effectively and efficiently remove chromium from the aqueous environment. The project focuses on the comparison of the effects of pH, time, temperature, binding capacity on bio-char’ generated from agricultural waste produces vs an amino modified derivative of the bio-char. Pineapple skins were dried, ground, sieved, and pyrolyzed to produce a bio-char material. The bio-char was analyzed using FTIR to …


Remediation Of Trivalent And Hexavalent Chromium Ions From Aqueous Solutions Using Titanium Dioxide Polymorphs, Yvette Cantu Dec 2017

Remediation Of Trivalent And Hexavalent Chromium Ions From Aqueous Solutions Using Titanium Dioxide Polymorphs, Yvette Cantu

Theses and Dissertations

Three titanium dioxide (TiO2) polymorphs were synthesized and used for the removal of chromium (III) and chromium (VI) from aqueous solutions. Various solution parameters were studied to determine the effects of pH, temperature, time, possible interfering ions, and capacities on the binding of Cr(III) and Cr(VI) to all three polymorphs. pH assays determined the optimum pH for the binding of both Cr(III) and Cr(VI) to each polymorph. Adsorption isotherms determined that the adsorption of Cr(III) was non-spontaneous for the three polymorphs with ΔG values ranging from 6.03 to 12.89 kJ/mol. Furthermore, the binding of Cr(VI) to anatase was also non-spontaneous …


Remediation Of Lead And Copper Ions From Water Solutions Using Transition Metal Sulfides, Jesus M. Cantu Jr. Dec 2017

Remediation Of Lead And Copper Ions From Water Solutions Using Transition Metal Sulfides, Jesus M. Cantu Jr.

Theses and Dissertations

Heavy metal contamination in water solutions has been a major concern since many transition metals don’t play a role in any biological function and are actually detrimental to human health. There have been several techniques that have been implemented for the remediation of heavy metal contaminants. For this project, three metal sulfides—Fe7S8, ZnS, TiS 2—were synthesized and studied for their capabilities to remove Pb(II) and Cu(II) from water solutions. Several parameters were investigated to determine the effects of pH, time, temperature, binding capacities, and interfering ions. The room temperature adsorption capacities ranged 6.23–333.3 mg/g for Pb(II) and 1.31–250 mg/g for …


Development Of Lower Rio Grande River Water Quality Transportation Numerical Model For Bi-National River Management, Jose O. Gonzalez Aug 2017

Development Of Lower Rio Grande River Water Quality Transportation Numerical Model For Bi-National River Management, Jose O. Gonzalez

Theses and Dissertations

Traditionally, water quality modelling has focused on modelling individual water bodies. However, water quality management problems must be analyzed at the larger scale to include influences from various water bodies that are interconnected. This paper provides a study on the hydrologic and quality transportation calculation by developing a hydrodynamic (unsteady state) channel routing model using a water-balanced approach. A one dimension Lagrangian river model was developed and applied to the 210 plus miles for the lower Rio Grande River Basin from the Falcon Dam to the head water of Brownsville that pours onto the Gulf of Mexico. This model can …


Removal Of Lead And Arsenic From Aqueous Solution By Biochar Produced From Locally-Sourced Biomass, Sergio I. Mireles Jul 2017

Removal Of Lead And Arsenic From Aqueous Solution By Biochar Produced From Locally-Sourced Biomass, Sergio I. Mireles

Theses and Dissertations

This study evaluated the effectiveness of four adsorbent materials, pyrolyzed corn stover, orange peel, pistachio shell, and magnetic biochar for their ability to adsorb lead (Pb) and arsenic (As III, As V) from aqueous solution. An increase in adsorption was seen as the pH of the solution increased from pH 2 to pH 6. Magnetic orange peel biochar with Fe3O4 particles precipitated on the surface of biochar was synthetized by co-precipitation and used for arsenic adsorption. Initial pH value had an influence on the adsorption behavior of As (III) and As (V). In the pH range of 2–6, As (V) …


Multi-Type Branching Processes Model Of Nosocomial Epidemic, Zeinab Nageh Mohamed May 2017

Multi-Type Branching Processes Model Of Nosocomial Epidemic, Zeinab Nageh Mohamed

Theses and Dissertations

The potency of an infectious disease to spread between different types of susceptible individuals in a hospital determines the fate of controlling nosocomial epidemics. I use a multi-type branching process with a joint negative binomial offspring distribution to study nosocomial epidemics. In particular, I estimate the basic reproduction number R0 and study its relationship with the offspring distribution’s parameters at different and fixed number of generations. Also, I study the effect of contact tracing on estimates of R0.


Disease Modeling Using Fractional Differential Equations And Estimation, Daniel P. Medina May 2017

Disease Modeling Using Fractional Differential Equations And Estimation, Daniel P. Medina

Theses and Dissertations

Ordinary differential equations has been the most conventional approach when modeling spread of infectious diseases. Effective research has shown that using fractional-order differentiation can be a very useful and efficient extension for some mathematical models. In this thesis, fractional calculus is used to depict an SEIR model with a system of fractional-order differential equations. I also simulate the fractional-order SEIR using integer-order numerical methods. I also establish the estimation framework and show that it is accurately working.


Coupled Telegraph And Sir Model Of Information And Diseases, Jose De Jesus Galarza May 2017

Coupled Telegraph And Sir Model Of Information And Diseases, Jose De Jesus Galarza

Theses and Dissertations

In this work, the effect of information propagation on disease spread and vaccination uptake through networks is studied. In this model the information reaches different people at different distances from the center of information containing the health data. We use a pair of Telegraph equations to depict the vaccine and disease information propagation on a network embedded into a straight line. The Telegraph equation is coupled with an SIR (Susceptible-Infected-Recovered) model to examine the anticipated mutual influence. Numerical simulations and stability analysis were made to study the model. We show how the propagation of information about the disease impacts the …


Mathematical Modeling Of Mers-Cov Nosocomial Epidemic, Adriana Quiroz May 2017

Mathematical Modeling Of Mers-Cov Nosocomial Epidemic, Adriana Quiroz

Theses and Dissertations

This thesis concerns about the analysis and modeling of spread of an infectious disease inside a hospital. We begin from the basic knowledge of the simple models: SIR and SEIR, to show an appropriate understanding of the epidemic dynamic process. We consider the Middle East Respiratory Syndrome Corona Virus (MERS-CoV), in Saudi Arabia, to introduce MERS-CoV SEIR ward model by developing different systems of equations in each ward (unit). We use the Next Generation Matrix method to calculate the basic reproduction number R0. Simulations of different scenarios are done using different combination of parameters.

To model MERS-CoV we established …


Investigating The Application Of Multibeam Sonar And Remotely Operated Vehicles In Fish Population Monitoring On Artificial Reefs, Robert Figueroa-Downing May 2017

Investigating The Application Of Multibeam Sonar And Remotely Operated Vehicles In Fish Population Monitoring On Artificial Reefs, Robert Figueroa-Downing

Theses and Dissertations

Implementation of ROVs and multibeam imaging sonar in fisheries research has the potential to improve the accuracy and efficiency of current monitoring practices. This study aimed to 1) compare ROV video and diver abundance estimates; 2) evaluate fish length measurement accuracy from sonar; 3) investigate key differentiating sonar characteristics. Results indicate: 1) Diver surveys captured greater diversity of species; survey methods were comparable with regards to conspicuous species (r = 0.089, p = 0.074); 2) Length measurements from multibeam imaging sonar had high predictive power (Rho = 0.998; p < 0.001) of actual standard lengths and; 3) variations between samples were largely due to swim bladder echo, relative position of the target fish, and schooling characteristics. We conclude that 1) ROVs are less apt at observing cryptic species; 2) The Blueview P900-90 sonar can accurately measure fish length; and 3) swim bladder morphology plays an important role in fish identification.


Environmental And Climatic Constraints On Large-Scale Camelina Production In Eastern Arkansas, Benjamin Robert Tracy May 2017

Environmental And Climatic Constraints On Large-Scale Camelina Production In Eastern Arkansas, Benjamin Robert Tracy

Graduate Theses and Dissertations

Camelina sativa is a cold weather crop that is typically grown in semi-arid environments in the Western United States, usually as a spring crop, but sometimes during the winter. Research analyzing climate data and soil hydrology is important to better understand the environmental and terrain conditions necessary for Camelina farming wherever it is proposed for large-scale production. This study focused on various conditions and constraints pertaining to the potential for Camelina as a crop biofuel in Eastern Arkansas. Due to interest in the economic potential of crop biofuels in this area, and in particular the low input costs for Camelina, …


Ambient Ionization - Mass Spectrometry: Advances Toward Intrasurgical Cancer Detection, Alan Keith Jarmusch Dec 2016

Ambient Ionization - Mass Spectrometry: Advances Toward Intrasurgical Cancer Detection, Alan Keith Jarmusch

Open Access Dissertations

My dissertation research has focused on the development of ambient ionization – mass spectrometry (MS) for clinical measurements, specifically intrasurgical cancer detection. The molecular differences between normal and cancerous tissue were detected via direct tissue analysis in vitro by touch spray ionization (TS) or by analyzing sectioned or smeared tissue using desorption electrospray ionization (DESI). The physical form of the tissue, e.g. in vitro sampling, sectioned, or smeared, was inconsequential in differentiating normal from cancerous tissue; however, the spectra acquired by TS and DESI differed due to differences in ionization processes. We envision that TS-MS and DESI-MS could impact diagnostic …


Quantifying Terrestrial Ecosystem Carbon Dynamics With Mechanistically-Based Biogeochemistry Models And In Situ And Remotely Sensed Data, Shaoqing Liu Dec 2016

Quantifying Terrestrial Ecosystem Carbon Dynamics With Mechanistically-Based Biogeochemistry Models And In Situ And Remotely Sensed Data, Shaoqing Liu

Open Access Dissertations

Terrestrial ecosystem plays a critical role in the global carbon cycle and climate system. Therefore, it is important to accurately quantify the carbon dynamics of terrestrial ecosystem under future climatic change condition. This dissertation evaluates the regional carbon dynamics by using upscaling approach, mechanistically-based biogeochemistry models and in situ and remotely sensed data.

The upscaling studies based on FLUXNET network has provided us the spatial and temporal pattern of the carbon fluxes but it fails to consider the atmospheric CO2 effect given its important physiological role in carbon assimilation. In the second chapter, we consider the effect of atmospheric CO2 …


Lower Food Web Dynamics In Lakes Michigan And Huron: Spatial And Temporal Responses To Recent Oligotrophication, Margaret Hutton Stadig Dec 2016

Lower Food Web Dynamics In Lakes Michigan And Huron: Spatial And Temporal Responses To Recent Oligotrophication, Margaret Hutton Stadig

Open Access Theses

Nutrient abatement programs, originally enacted to counter eutrophication have successfully suppressed nutrient loads and relative primary production in marine and freshwater systems. Recently, the additive impacts of invasive filter feeders have further reduced offshore primary production in several aquatic systems throughout the world. It has been hypothesized that the biological activity of these invasive species may sequester nutrients within the nearshore benthic environment, creating steep gradients in primary production between nearshore and offshore habitats. In the Laurentian Great Lakes, past studies of oligotrophication have primarily focused on food web responses in offshore habitats. Organisms at higher trophic levels have been …


Mathematical Analysis Of Feedback Targets Of Bmp Signaling In Drosophila Embryonic Development, Yan Luo Dec 2016

Mathematical Analysis Of Feedback Targets Of Bmp Signaling In Drosophila Embryonic Development, Yan Luo

Open Access Theses

Bone morphogenetic proteins (BMPs) drive a range of cellular processes especially in the early stages of embryonic development. This family of proteins acts as one of the most important extracellular signals in development pattern formation across the animal kingdom. Cells in embryos differentiate into different cell types in response to the concentration level of BMP. This complex process is regulated by multiple regulators that serve to tune the signal response.

Extensive experimental and computational research has been performed to analyze BMP regulation in Drosophila, a widely studied model organism, and has advanced our understanding of animal development. Because of …


Gonadal Intersex In Teleosts: Mechanisms, Molecular Biomarkers And Diagnostic Assays, Ahmed M.E. Abdel-Moneim Mohamed Dec 2016

Gonadal Intersex In Teleosts: Mechanisms, Molecular Biomarkers And Diagnostic Assays, Ahmed M.E. Abdel-Moneim Mohamed

Open Access Dissertations

Natural and synthetic estrogenic and androgenic compounds are continuously released into aquatic ecosystems. Exposure of teleost fishes to these contaminants can negatively impact sex differentiation and reproductive output. Specifically, development of gonadal intersex in gonochoristic (fixed sex) fish species has been studied extensively in relation to exposure to this class of compounds. The main objectives of this dissertation were to: 1) conduct field and laboratory studies to investigate the molecular signaling pathways behind the development of gonadal intersex; and 2) establish molecular biomarkers and assays for testing the ability of environmental pollutants to develop this condition using a battery of …


Unraveling The Fingerprints Of Nox Using Stable Isotopes: Implications For Nox Source Partitioning And Oxidation Chemistry, Wendell William Walters Dec 2016

Unraveling The Fingerprints Of Nox Using Stable Isotopes: Implications For Nox Source Partitioning And Oxidation Chemistry, Wendell William Walters

Open Access Dissertations

The nitrogen (N) and oxygen (O) stable isotope composition (δ15N & δ18O) of nitrogen oxides (NOx )may be a useful tool for constraining NOx emission sources as well as for understanding the atmospheric oxidation pathways responsible for its removal if various NOx sources and sink processes exhibit characteristic isotopic compositions (“fingerprints”). However, this requires (1) an accurate and complete inventory of δ15N(NOx) values from major emission sources, (2) an assessment of the kinetic and equilibrium isotope effects that can impact δ15N and δ18O values of NOx, (3) and test these assumptions by conducting accurate in situ δ15N and δ18O measurements …


Willingness To Pay For Irrigation Water Under Scarcity Conditions, Tyler Robert Knapp Dec 2016

Willingness To Pay For Irrigation Water Under Scarcity Conditions, Tyler Robert Knapp

Graduate Theses and Dissertations

Reliance of Arkansas agricultural producers on groundwater for irrigation has led to depletion of the Mississippi River Valley alluvial aquifer. Without intervention, consequences include insufficient groundwater to meet irrigation demand as well as drawdown of the deeper Sparta Aquifer, upon which communities in eastern Arkansas rely for non-agricultural use. Among proposed solutions to combat groundwater decline is the construction of off-farm surface water infrastructure to meet the irrigation needs of producers. Despite the importance of irrigated agriculture to Arkansas, there is little know about the economic value of irrigation water to producers. Thus, we implement a double-bounded dichotomous choice contingent …


Gastrointestinal Health As A Stimulus For Native American Attraction To Medicinal Asteraceae And Further Implications For Human Evolution, Christopher David Stiegler Dec 2016

Gastrointestinal Health As A Stimulus For Native American Attraction To Medicinal Asteraceae And Further Implications For Human Evolution, Christopher David Stiegler

Graduate Theses and Dissertations

The Asteraceae, or the daisy family, is the largest family of flowering plants in the world, and its ethnobotanical, medical, and economic value is readily apparent cross-culturally. The aim of this thesis is to examine why constituent genera of the Aster family have remained such an integral part of human medicinal plant knowledge, and thereby to reveal any potential physiological, biological, or evolutionary mechanisms underlining human patterns of use regarding the Asteraceae. The present study focuses specifically on Native American plant knowledge made available by the expansive database in the works Daniel Moerman (Moerman 2003). Frequencies of plant use and …


Liming Characteristics Of A High-Calcium, Dry Flue Gas Desulfurization By-Product And Its Effects On Runoff Water Quality, Jason Richard Burgess-Conforti Dec 2016

Liming Characteristics Of A High-Calcium, Dry Flue Gas Desulfurization By-Product And Its Effects On Runoff Water Quality, Jason Richard Burgess-Conforti

Graduate Theses and Dissertations

In 2013, only 37% of the 32 million Mg of flue gas desulfurization (FGD) by-products generated in the United States were reused beneficially. If FGD by-products could be used as a beneficial soil amendment, millions of megagrams may be diverted away from surface impoundments and landfills. The purpose of this research was to identify the liming characteristics of a high-Ca dry FGD (DFGD) by-product in comparison to a Class-C fly ash (FA) and reagent-grade CaCO3, and to evaluate the effects of land application to a managed grassland on runoff, plant, and soil quality. Liming characteristics were determined by measuring the …


The Associations Between Environmental Quality And Mortality In The Contiguous United States, 2000-2005, Yun Jian, Lynne C. Messer, Jyotsna S. Jagai, Kristen M. Rappazzo, Christine L. Gray, Shannon C. Grabich, Danelle T. Lobdell Oct 2016

The Associations Between Environmental Quality And Mortality In The Contiguous United States, 2000-2005, Yun Jian, Lynne C. Messer, Jyotsna S. Jagai, Kristen M. Rappazzo, Christine L. Gray, Shannon C. Grabich, Danelle T. Lobdell

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background: Assessing cumulative effects of the multiple environmental factors influencing mortality remains a challenging task.

Objectives: This study aimed to examine the associations between cumulative environmental quality and all-cause and leading cause-specific (heart disease, cancer, and stroke) mortality rates.

Methods: We used the overall Environmental Quality Index (EQI) and its five domain indices (air, water, land, built and sociodemographic) to represent environmental exposure. Associations between the EQI and mortality rates (CDC WONDER) for counties in the contiguous United States (n=3109) were investigated using multiple linear regression models, and random intercept, random slope hierarchical models. Urbanicity, climate and their combination were …


Intestinal Adaptation To Repeated Exposure Of Flavonoid-Rich Foods: In Vitro And Clinical Data, Bejamin W. Redan Aug 2016

Intestinal Adaptation To Repeated Exposure Of Flavonoid-Rich Foods: In Vitro And Clinical Data, Bejamin W. Redan

Open Access Dissertations

Interest in application of flavonoids for chronic disease prevention has grown significantly, but the low oral bioavailability of these compounds from acute doses is commonly highlighted as a limitation when considering their biological significance. Still, the impact of broad dietary patterns such as repeated exposure on flavonoid’s absorption, metabolism, and eventual efficacy is critical to consider since evidence suggests that their bioavailability may be enhanced with repeated exposure. To fill this gap in knowledge, this dissertation will focus on three major areas including characterization of flavonoid metabolites, in addition to use of in vitro models and clinical work to test …


A Dose Distribution Study Of Uranyl Nitrate In Zebrafish Using Liquid Scintillation And Passivated Implanted Planar Silicon Detectors, Lee A. Alleman Aug 2016

A Dose Distribution Study Of Uranyl Nitrate In Zebrafish Using Liquid Scintillation And Passivated Implanted Planar Silicon Detectors, Lee A. Alleman

Open Access Theses

Standard curves for a Perkin Elmer TriCarb 2800 liquid scintillation detector (LSC) and a Ludlum 3030p Passivated Implanted Planar Silicon detector have been developed and utilized for studying the dose distribution of depleted uranium (DU) within zebrafish. The DU source was crystallized uranyl nitrate (N2O8U•6H2O) solution, normally used for staining in electron microscopy with a manufactured average specific activity of 0.3 uCi/g. Zebrafish, both larvae and adults, were exposed to three different mass concentrations, dissected, dissolved and counted using an LSC. The counts were compared to the standard curve correlating the measured activity to that of the mass absorbed. It …