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2023

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Articles 13501 - 13530 of 14121

Full-Text Articles in Physical Sciences and Mathematics

Optimal Adaptive Tracking Control Of Partially Uncertain Nonlinear Discrete-Time Systems Using Lifelong Hybrid Learning, Behzad Farzanegan, Rohollah Moghadam, Sarangapani Jagannathan, Pappa Natarajan Jan 2023

Optimal Adaptive Tracking Control Of Partially Uncertain Nonlinear Discrete-Time Systems Using Lifelong Hybrid Learning, Behzad Farzanegan, Rohollah Moghadam, Sarangapani Jagannathan, Pappa Natarajan

Electrical and Computer Engineering Faculty Research & Creative Works

This article addresses a multilayer neural network (MNN)-based optimal adaptive tracking of partially uncertain nonlinear discrete-time (DT) systems in affine form. By employing an actor–critic neural network (NN) to approximate the value function and optimal control policy, the critic NN is updated via a novel hybrid learning scheme, where its weights are adjusted once at a sampling instant and also in a finite iterative manner within the instants to enhance the convergence rate. Moreover, to deal with the persistency of excitation (PE) condition, a replay buffer is incorporated into the critic update law through concurrent learning. To address the vanishing …


Lifelong Learning-Based Multilayer Neural Network Control Of Nonlinear Continuous-Time Strict-Feedback Systems, Irfan Ahmad Ganie, S. (Sarangapani) Jagannathan Jan 2023

Lifelong Learning-Based Multilayer Neural Network Control Of Nonlinear Continuous-Time Strict-Feedback Systems, Irfan Ahmad Ganie, S. (Sarangapani) Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

In This Paper, We Investigate Lifelong Learning (LL)-Based Tracking Control for Partially Uncertain Strict Feedback Nonlinear Systems with State Constraints, employing a Singular Value Decomposition (SVD) of the Multilayer Neural Networks (MNNs) Activation Function based Weight Tuning Scheme. the Novel SVD-Based Approach Extends the MNN Weight Tuning to (Formula Presented.) Layers. a Unique Online LL Method, based on Tracking Error, is Integrated into the MNN Weight Update Laws to Counteract Catastrophic Forgetting. to Adeptly Address Constraints for Safety Assurances, Taking into Account the Effects Caused by Disturbances, We Utilize a Time-Varying Barrier Lyapunov Function (TBLF) that Ensures a Uniformly Ultimately …


Introduction To Contemporary Mathematics Syllabus (Spring 2023), Heather Nunnally Jan 2023

Introduction To Contemporary Mathematics Syllabus (Spring 2023), Heather Nunnally

Open Textbooks and Course Materials

This syllabus was used in the Spring of 2023 for MATH 131: Introduction to Contemporary Mathematics. There were no textbook costs for this course; instead, MyOpenMath was used for the textbook and homework.


Efficient High Order Ensemble For Fluid Flow, John Carter Jan 2023

Efficient High Order Ensemble For Fluid Flow, John Carter

Doctoral Dissertations

"This thesis proposes efficient ensemble-based algorithms for solving the full and reduced Magnetohydrodynamics (MHD) equations. The proposed ensemble methods require solving only one linear system with multiple right-hand sides for different realizations, reducing computational cost and simulation time. Four algorithms utilize a Generalized Positive Auxiliary Variable (GPAV) approach and are demonstrated to be second-order accurate and unconditionally stable with respect to the system energy through comprehensive stability analyses and error tests. Two algorithms make use of Artificial Compressibility (AC) to update pressure and a solenoidal constraint for the magnetic field. Numerical simulations are provided to illustrate theoretical results and demonstrate …


An Unmanned Aircraft System For Marking Live Power Lines To Prevent Bird Collisions, Mattheuns D. Pretorius, Lourens Leeuwner, Kaajial Durgapersad, Constant Hoogstad, Peter Beckedahl, Michael D. Michael, Kishaylin Chetty Jan 2023

An Unmanned Aircraft System For Marking Live Power Lines To Prevent Bird Collisions, Mattheuns D. Pretorius, Lourens Leeuwner, Kaajial Durgapersad, Constant Hoogstad, Peter Beckedahl, Michael D. Michael, Kishaylin Chetty

Human–Wildlife Interactions

Collisions with overhead power lines represent a significant cause of mortality for a number of large bird species worldwide. Certain threatened species are severely impacted by power line collisions, particularly those for which there are no other known significant threats. In South Africa, bird collisions with overhead power line cables, including collisions with phase conductors and shield wires, contribute significantly to annual threatened bird species mortalities associated with Eskom power lines. The most practical mitigation measure is to attach bird anti-collision devices as markers on the cables. Current marking methods involve installations by hand, where linemen are hoisted up to …


Impacts Of Land Cover Change On Urban Heat Island (Uhi) In Denver From 1985 To 2020, Sadia Islam Ritu Jan 2023

Impacts Of Land Cover Change On Urban Heat Island (Uhi) In Denver From 1985 To 2020, Sadia Islam Ritu

Electronic Theses and Dissertations

Rapid urbanization due to land use and land cover change has become one of the major problems in the fastest-growing cities during the past few decades. Land surface temperature has changed dramatically due to urban expansion, and it is a major driver of urban eco-environmental change. Increasing temperature leads to the Urban Heat Island (UHI) problem in rapidly growing cities like Denver, contributing to global warming at multiple scales. UHI study is significant to monitor and mitigate the urban heat islandrelated problem in the study area Denver. Satellite remote sensing analysis ready data (ARD) with 30 m resolution based on …


Some 2-Color Rado Numbers For A Linear Equation With A Negative Constant, Rachel Bergjord Jan 2023

Some 2-Color Rado Numbers For A Linear Equation With A Negative Constant, Rachel Bergjord

Electronic Theses and Dissertations

An r-coloring is a function Δ that assigns a color to each natural number from 1 to some number n using colors 0, 1, . . . , r − 1. A monochromatic solution (in Δ) to an equation L with m variables is an ordered m-tuple (x1, x2, . . . , xm) where Δ(x1) = Δ(x2) = · · · = Δ(xm) and (x1, x2, . . . , xm−1, xm) solves L. Given a linear equation L and t ∈ N, the t-color Rado number for L is the least integer n (if it exists) such that …


Identification And Quantification Of Novel Antimicrobials, Hazera Khatun Koly Jan 2023

Identification And Quantification Of Novel Antimicrobials, Hazera Khatun Koly

Electronic Theses and Dissertations

No abstract provided.


Methods For Improving Potassium Fertilizer Recommendations For Corn In South Dakota, Andrew J. Ahlersmeyer Jan 2023

Methods For Improving Potassium Fertilizer Recommendations For Corn In South Dakota, Andrew J. Ahlersmeyer

Electronic Theses and Dissertations

Corn (Zea mays L.) is a vital commodity in South Dakota’s agricultural sector. Optimal corn production occurs when there are sufficient mineral nutrients in the soil, especially potassium (K). Applications of K fertilizer are used when soil test K (STK) levels are deficient. Therefore, producers need reliable, thoroughly tested fertilizer recommendations to make profitable decisions and maintain environmental stewardship. South Dakota K fertilizer recommendations have not been updated in nearly 20 years. Simultaneously, changes in corn genetics, management practices, and climate patterns suggest that the critical soil test value (CSTV) for STK may have shifted in that same time frame. …


Cytotoxicity Profiling And Apoptotic Potential Of Carboxylic Acids-Based Deep Eutectic Solvents On Mammalian Cell Lines, Mavis Korankye Jan 2023

Cytotoxicity Profiling And Apoptotic Potential Of Carboxylic Acids-Based Deep Eutectic Solvents On Mammalian Cell Lines, Mavis Korankye

Electronic Theses and Dissertations

In the past few years, there has been a notable surge in demand for high-purity medicines due to the prevalence of chronic diseases such as cancer, hypertension, diabetes, cardiovascular diseases, and neurological disorders. Considerable efforts have been dedicated to discovering new solvents that are environmentally friendly and cost-effective that are well-suited for industrial applications. Deep eutectic solvents have gained recognition as a highly promising alternative to organic solvents and ionic liquids due to their easily sourced raw materials, simple and cheap preparation methods, high tunability, low volatility, low toxicity, and biodegradability. The industrial utilization of deep eutectic solvents (DESs) is …


The Live Bait Trade As A Pathway Of Inland Invasive Fish Species Introductions, Hannah Mulligan Jan 2023

The Live Bait Trade As A Pathway Of Inland Invasive Fish Species Introductions, Hannah Mulligan

Electronic Theses and Dissertations

Freshwater systems are susceptible to numerous anthropogenic pathways of invasive species introductions and subsequent establishment. Once establishment occurs, invasive species not only impact biodiversity, ecosystem function, and human health, but also cost the global economy billions of dollars every year. Recreational fishing is one of the most prevalent pathways for invasive species introductions in freshwater systems due to increased propagule pressure from boating and angling activity. Within recreational fishing, the live bait trade represents a secondary pathway whereby anglers illegally release baitfish (and water) that may contain invasive species. Preventative actions, including regulations, education, and inspections have been implemented to …


Understanding The Role Of Hba/Hbd Variations On Deep Eutectic Solvent Properties And Activity Using Acetylsalicylic Acid As A Model Drug, Michael Frimpong Jan 2023

Understanding The Role Of Hba/Hbd Variations On Deep Eutectic Solvent Properties And Activity Using Acetylsalicylic Acid As A Model Drug, Michael Frimpong

Electronic Theses and Dissertations

Deep eutectic solvents (DES) are emerging as a versatile class of solvents, attracting considerable attention for their unique solvent properties and potential applications. This study examines the effects of variations in combinations as well as molar ratios of hydrogen-bond acceptor (HBA) and hydrogen-bond donor (HBD) on the structure of DES. It further explores the structure-activity relationship, measured using the rate of acetylsalicylic acid (ASA) degradation in the solvent. The project is based on the model that variations in HBA/HBD combinations and their relative molar ratios impact the solvent structure (hydrogen bonding), observable in physicochemical measurements, infrared (IR), and nuclear magnetic …


Effects Of Agricultural Chemicals On Native Plants Of The Northern Great Plains, Gabrielle Bolwerk Jan 2023

Effects Of Agricultural Chemicals On Native Plants Of The Northern Great Plains, Gabrielle Bolwerk

Electronic Theses and Dissertations

Agricultural chemicals are ubiquitous on the Northern Great Plains landscape and have negative impacts on non-target plant communities, even at small doses. Northern Great Plains grassland plant communities may experience herbicide drift from agricultural fields or be subject to livestock pharmaceuticals in grazing lands. My research objective was to evaluate if and how native plants are affected by agricultural chemical presence at different concentrations. In Chapter 2, I studied the effect of different concentrations of three common agricultural herbicides (2,4-D, atrazine, and trifluralin) on the germination, emergence, and growth of native plant species of the Northern Great Plains. I performed …


Investigations Into The Electronic And Magnetic Properties Of (Crps4)N Layers, Alexandria R. Alcantara Jan 2023

Investigations Into The Electronic And Magnetic Properties Of (Crps4)N Layers, Alexandria R. Alcantara

UNF Graduate Theses and Dissertations

2D magnetic semiconductors have become of interest due to their magneto-optical effects in lower dimensionality. More specifically, CrPS4 has gained renewed attention due to its A-type AFM order and air stability prompting analysis and stability studies in its layered forms for use in scalable technology such as spintronic and optoelectronic devices. In this study, we benchmark our approach using the SCAN meta-GGA functional used without U-parameterization on bulk CrPS4 to demonstrate the accuracy of our methodology to use as tools to go beyond current CrPS4 theoretical studies. We examine the 2D electronic nature and optical spectrum for use in experimental …


Elliptic Functions And Iterative Algorithms For Π, Eduardo Jose Evans Jan 2023

Elliptic Functions And Iterative Algorithms For Π, Eduardo Jose Evans

UNF Graduate Theses and Dissertations

Preliminary identities in the theory of basic hypergeometric series, or `q-series', are proven. These include q-analogues of the exponential function, which lead to a fairly simple proof of Jacobi's celebrated triple product identity due to Andrews. The Dedekind eta function is introduced and a few identities of it derived. Euler's pentagonal number theorem is shown as a special case of Ramanujan's theta function and Watson's quintuple product identity is proved in a manner given by Carlitz and Subbarao. The Jacobian theta functions are introduced as special kinds of basic hypergeometric series and various relations between them derived using the triple …


The Lie Algebra Sl2(C) And Krawtchouk Polynomials, Nkosi Alexander Jan 2023

The Lie Algebra Sl2(C) And Krawtchouk Polynomials, Nkosi Alexander

UNF Graduate Theses and Dissertations

The Lie algebra L = sl2(C) consists of the 2 × 2 complex matrices that have trace zero, together with the Lie bracket [y, z] = yz − zy. In this thesis we study a relationship between L and Krawtchouk polynomials. We consider a type of element in L said to be normalized semisimple. Let a, a^∗ be normalized semisimple elements that generate L. We show that a, a^∗ satisfy a pair of relations, called the Askey-Wilson relations. For a positive integer N, we consider an (N + 1)-dimensional irreducible L-module V consisting of the homogeneous polynomials in two variables …


Breast Density Classification Using Deep Learning, Conrad Thomas Testagrose Jan 2023

Breast Density Classification Using Deep Learning, Conrad Thomas Testagrose

UNF Graduate Theses and Dissertations

Breast density screenings are an accepted means to determine a patient's predisposed risk of breast cancer development. Although the direct correlation is not fully understood, breast cancer risk increases with higher levels of mammographic breast density. Radiologists visually assess a patient's breast density using mammogram images and assign a density score based on four breast density categories outlined by the Breast Imaging and Reporting Data Systems (BI-RADS). There have been efforts to develop automated tools that assist radiologists with increasing workloads and to help reduce the intra- and inter-rater variability between radiologists. In this thesis, I explored two deep-learning-based approaches …


Assessing The Performance Of A Particle Swarm Optimization Mobility Algorithm In A Hybrid Wi-Fi/Lora Flying Ad Hoc Network, William David Paredes Jan 2023

Assessing The Performance Of A Particle Swarm Optimization Mobility Algorithm In A Hybrid Wi-Fi/Lora Flying Ad Hoc Network, William David Paredes

UNF Graduate Theses and Dissertations

Research on Flying Ad-Hoc Networks (FANETs) has increased due to the availability of Unmanned Aerial Vehicles (UAVs) and the electronic components that control and connect them. Many applications, such as 3D mapping, construction inspection, or emergency response operations could benefit from an application and adaptation of swarm intelligence-based deployments of multiple UAVs. Such groups of cooperating UAVs, through the use of local rules, could be seen as network nodes establishing an ad-hoc network for communication purposes.

One FANET application is to provide communication coverage over an area where communication infrastructure is unavailable. A crucial part of a FANET implementation is …


Apparent Contours For Piecewise Smooth Surfaces, Sarah Marie Jackman Jan 2023

Apparent Contours For Piecewise Smooth Surfaces, Sarah Marie Jackman

UNF Graduate Theses and Dissertations

The set of points on an embedded surface $M$ that are tangent to a set viewing direction $\mathbf{v}$ is called the contour generator of $M$. The projection of those points to an image plane is called a surface's apparent contour. Apparent contours hold certain properties that allow for reconstruction of the original surface using only the information of the apparent contour. In this paper, we explore the structure of the apparent contour through contact classes and singularity types. Additionally we examine the properties of apparent contours that allow for 3 dimensional reconstruction. Our goal is to extend the properties of …


Exploring Mottness And Electronic Order In Strongly Correlated Vanadate Thin Films, Nathan Bairen Jan 2023

Exploring Mottness And Electronic Order In Strongly Correlated Vanadate Thin Films, Nathan Bairen

UNF Graduate Theses and Dissertations

Mott insulators provide a window into some of the most intensely investigated phenomena in physics. Recent discoveries—including the emergence of high-temperature superconductivity in doped Mott insulators not from the cuprate family of superconductors—have inspired investigation into systems with strong electron-electron interactions. One of these systems is La1-xSrxVO3, in which one end-member, LaVO3, is a Mott insulator and the other, SrVO3, is a strongly correlated metal.

Herein, we detail two studies regarding this system. In our oxidation study, we optimized the growth parameters for LaVO3, finding that the ultra-high vacuum technique …


Ovulation Prediction Using Random Forest Algorithm On Physiological Data, Kimberly D. Laynes Jan 2023

Ovulation Prediction Using Random Forest Algorithm On Physiological Data, Kimberly D. Laynes

UNF Graduate Theses and Dissertations

Human infertility rates are on the rise -- studies have shown that one in every four women have trouble conceiving and every year those rates are rising [Halleran22]. This trend motivates procedures such as in-vitro fertilization (IVF) and intrauterine insemination (IUI) to produce a pregnancy. Such procedures are not only intricate and expensive but also carry potential unintended consequences for women's physical and mental well-being. A more profound comprehension of the menstrual cycle and its multiple phases, particularly detecting the ovulation period itself, promotes optimized treatment outcomes and reduces associated risks. To facilitate ovulation detection, new sensing technologies built into …


Extracting Road Surface Marking Features From Aerial Images Using Deep Learning, Michael Kimollo Jan 2023

Extracting Road Surface Marking Features From Aerial Images Using Deep Learning, Michael Kimollo

UNF Graduate Theses and Dissertations

The traffic and roadway safety agencies spend significant efforts each year collecting roadway data, including lane configurations and other road surface marking data, such as areas with school zone markings, sidewalks, left turns, right turns, bicycle lanes, etc., for safety analysis and planning purposes. The current manual data collection methods pose significant operational and quality control challenges as they are costly and prone to errors. In addition to that the manual data collection is labor intensive and takes too much time involving high equipment costs, questionable data accuracy guarantees, and concerns about the safety of the crew.

This study aims …


Novel Approaches To Compute Manifold Operators With The Radial Basis Functions Method, Jacob James Blazejewski Jan 2023

Novel Approaches To Compute Manifold Operators With The Radial Basis Functions Method, Jacob James Blazejewski

Dissertations, Master's Theses and Master's Reports

The bulk of this dissertation is mainly composed of four chapters, which are organized as follows: Chapter 1 provides an introduction to the Radial Basis Functions (RBF) method by briefly outlining its historical developments and reviewing the RBF interpolation and the RBF-Finite Difference (FD) methodologies, and their advantages/disadvantages. Chapter 2 describes the Orthogonal Gradients (OGr) method and the Fast OGr method and how these can be used to compute differential operators restricted to hypersurfaces and space curves ($\Gamma$) embedded in R3. We will highlight a challenge of pairing Fast OGr with RBF-FD on nearly flat local clusters and how to …


Additive P-Value Combination Test, Xing Ling Jan 2023

Additive P-Value Combination Test, Xing Ling

Dissertations, Master's Theses and Master's Reports

This dissertation includes four Chapters. A brief description of each chapter is organized as follows.

In Chapter 1, some developments on multiple hypotheses tests are introduced. Some preliminaries about the definition and the assumption are included.

In Chapter 2, a Stable Combination Test is proposed to combine $p$-values from multiple hypotheses tests. We show the proposed method controls the family-wise error rate at the target level and maintains asymptotically optimal power even when the elementary p-values from the individual hypotheses are dependent.

In Chapter 3, a deeper dig into the additive p-value combination test is performed. A common idea behind …


Invasive Buckthorn Mapping: A Uav-Based Approach Utilizing Machine Learning, Gis, And Remote Sensing Techniques In The Upper Peninsula Of Michigan, Vikranth Madeppa Jan 2023

Invasive Buckthorn Mapping: A Uav-Based Approach Utilizing Machine Learning, Gis, And Remote Sensing Techniques In The Upper Peninsula Of Michigan, Vikranth Madeppa

Dissertations, Master's Theses and Master's Reports

An Invasive species is a species that is alien or non-native to the ecosystem which causes harm to economic, environmental, or human health (E.O. 13112 of Feb 3, 1999). Invasive species have posed a serious threat to ecosystems across the globe. These invasive species have impacts on the biodiversity and productivity of invaded forests. Remotely sensed data is a valuable resource for understanding and addressing issues related to invasive species. This study presents a novel approach for mapping the distribution of two invasive plant species, Common and Glossy Buckthorn, using unmanned aerial vehicles (UAVs), machine learning algorithms, geographic information systems …


Climate Changes In El Salvador: Impacts Of ‘La Canícula’ (Midsummer Drought) On Agricultural Practices And Decision-Making In Rural Communities, Paola M. Rivera González Jan 2023

Climate Changes In El Salvador: Impacts Of ‘La Canícula’ (Midsummer Drought) On Agricultural Practices And Decision-Making In Rural Communities, Paola M. Rivera González

Dissertations, Master's Theses and Master's Reports

The Central American Dry Corridor (CADC), a tropical, dry-forest region, is characterized by distinct rainy and dry seasons, which influence the local agricultural calendar and planting decisions in rural communities. La canícula is a period of decreased precipitation during the rainy season, which occurs during the corn-planting season in El Salvador. La canícula is expected to change in intensity and duration in the next decades, which would impact small-scale farmers and their livelihoods. Climate variability and uncertainty has led to crop loss, water scarcity, and food insecurity in rural communities dependent on subsistence farming. Farmers’ experiences with a changing climate …


Chemical Decomposition Of Flexible Polyurethane Foam To Generate A Media For Microbial Upcycling, Kaushik Baruah Jan 2023

Chemical Decomposition Of Flexible Polyurethane Foam To Generate A Media For Microbial Upcycling, Kaushik Baruah

Dissertations, Master's Theses and Master's Reports

Polyurethane waste is becoming a global concern as a large amount is being disposed of in landfills every year, and only a fraction is being recycled. Several polyurethane recycling techniques exist, of which ammonolysis and base-catalyzed hydrolysis is the least explored. Flexible polyurethane foam (FPUF) decomposition can generate amines that can act as a carbon source for the growth of microbial consortia. This study aims to generate a novel media capable of microbial upcycling via ammonolysis and base-catalyzed hydrolysis of flexible polyurethane foams (FPUFs) using ammonium hydroxide and subsequently determine the reaction conditions for maximum solubilization of polyurethane foam in …


Structural Analysis And Slip Kinematics Of The Keweenaw Fault System Between Bête Grise Bay And Gratiot Lake, Keweenaw County, Michigan, Daniel J. Lizzadro-Mcpherson Jan 2023

Structural Analysis And Slip Kinematics Of The Keweenaw Fault System Between Bête Grise Bay And Gratiot Lake, Keweenaw County, Michigan, Daniel J. Lizzadro-Mcpherson

Dissertations, Master's Theses and Master's Reports

The Keweenaw fault is perhaps the most significant geologic structure on the Keweenaw Peninsula, with an estimated 7-11 km of reverse slip juxtaposing volcanic strata of the ~1.1 Ga Portage Lake Volcanics above ~1.0 Ga Jacobsville Sandstone. The fault has been interpreted as a rift-bounding normal fault later inverted by compressional pulses of the Grenville Orogeny or, more recently, as part of a detached thrust fault system unrelated to an earlier normal fault. The fault is shown on published maps as a single continuous fault trace whose sinuosity implies multiple fault segments and complex slip dynamics. Mapping along Bête Grise …


Study Of Electronic And Magnetic Properties Of Bilayer Graphene Nanoflakes And Bimetallic Chalcogenides Using First-Principles Density Functional Theory And Machine Learning, Dharmendra Pant Jan 2023

Study Of Electronic And Magnetic Properties Of Bilayer Graphene Nanoflakes And Bimetallic Chalcogenides Using First-Principles Density Functional Theory And Machine Learning, Dharmendra Pant

Dissertations, Master's Theses and Master's Reports

Graphene, a one-atom-thick material, has been a wonder material since its discovery because of its superlative electronic, mechanical, and optical properties. When a layer of graphene is rotated over another layer, it exhibits many intriguing behaviors, ranging from superconductivity to the anomalous Hall effect to ferromagnetism at a magic angle of 1°, and hence the twisted bilayer graphene has been the subject of intense research in recent years. The surge in interest in this moiré structure can be attributed to the emergence of electronic flat minibands near the magic angle. Here, we studied the electronic and magnetic properties of twisted …


Multiscale Molecular Modeling Studies Of The Dynamics And Catalytic Mechanisms Of Iron(Ii)- And Zinc(Ii)-Dependent Metalloenzymes, Sodiq O. Waheed Jan 2023

Multiscale Molecular Modeling Studies Of The Dynamics And Catalytic Mechanisms Of Iron(Ii)- And Zinc(Ii)-Dependent Metalloenzymes, Sodiq O. Waheed

Dissertations, Master's Theses and Master's Reports

Enzymes are biological systems that aid in specific biochemical reactions. They lower the reaction barrier, thus speeding up the reaction rate. A detailed knowledge of enzymes will not be achievable without computational modeling as it offers insight into atomistic details and catalytic species, which are crucial to designing enzyme-specific inhibitors and impossible to gain experimentally. This dissertation employs advanced multiscale computational approaches to study the dynamics and reaction mechanisms of non-heme Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases, including AlkB, AlkBH2, TET2, and KDM4E, involved in DNA and histone demethylation. It also focuses on Zn(II) dependent matrix metalloproteinase-1 (MMP-1), which helps …