Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Physical Sciences and Mathematics
Atp Binding Cassette Sub-Family Member 2 (Abcg2) And Xenobiotic Exposure During Early Mouse Embryonic Stem Cell Differentiation, Mitchell B. Rosen, Susan C. Jeffay, Harriette P. Nichols, Maria R. Hoopes, E. Sidney Hunter Iii
Atp Binding Cassette Sub-Family Member 2 (Abcg2) And Xenobiotic Exposure During Early Mouse Embryonic Stem Cell Differentiation, Mitchell B. Rosen, Susan C. Jeffay, Harriette P. Nichols, Maria R. Hoopes, E. Sidney Hunter Iii
United States Environmental Protection Agency: Staff Publications
Background: ATP binding cassette sub-family member 2 (ABCG2) is a welldefined efflux transporter found in a variety of tissues. The role of ABCG2 during early embryonic development, however, is not established. Previous work which compared data from the ToxCast screening program with that from in-house studies suggested an association exists between exposure to xenobiotics that regulate Abcg2 transcription and differentiation of mouse embryonic stem cells (mESC), a relationship potentially related to redox homeostasis.
Methods: mESC were grown for up to 9 days. Pharmacological inhibitors were used to assess transporter function with and without xenobiotic exposure. Proliferation and differentiation were …