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Full-Text Articles in Physical Sciences and Mathematics

Non-Human Primates In Neuroscience Research: The Case Against Its Scientific Necessity, Jarrod Bailey, Katy Taylor Sep 2016

Non-Human Primates In Neuroscience Research: The Case Against Its Scientific Necessity, Jarrod Bailey, Katy Taylor

Jarrod Bailey, PhD

Public opposition to non-human primate (NHP) experiments is significant, yet those who defend them cite minimal harm to NHPs and substantial human benefit. Here we review these claims of benefit, specifically in neuroscience, and show that: a) there is a default assumption of their human relevance and benefit, rather than robust evidence; b) their human relevance and essential contribution and necessity are wholly overstated; c) the contribution and capacity of non-animal investigative methods are greatly understated; and d) confounding issues, such as species differences and the effects of stress and anaesthesia, are usually overlooked. This is the case in NHP …


Reverse-Engineering The Brain: The Parts Are As Complex As The Whole., Jens G. Pohl Aug 2016

Reverse-Engineering The Brain: The Parts Are As Complex As The Whole., Jens G. Pohl

Collaborative Agent Design (CAD) Research Center

The purpose of this paper is to review the current state of neuroscience research with a focus on what has been achieved to date in unraveling the mysteries of brain operations, major research initiatives, fundamental challenges, and potentially realizable objectives. General research approaches aimed at constructing a wiring diagram of the brain (i.e., connectome), determining how the brain encodes and computes information, and whole brain simulation attempts are reviewed in terms of strategies employed and difficulties encountered. While promising advances have been made during the past 50 years due to electron microscopy, the development of new experimental methods, and the …


Symmetries Constrain Dynamics In A Family Of Balanced Neural Networks, Andrea Barreiro, J Nathan Kutz, Eli Shlizerman May 2016

Symmetries Constrain Dynamics In A Family Of Balanced Neural Networks, Andrea Barreiro, J Nathan Kutz, Eli Shlizerman

Biology and Medicine Through Mathematics Conference

No abstract provided.


Abrupt Transitions From Low To High Firing Frequencies In Neurons And Neuronal Networks, Ryusei Melody Takeuchi, Christoph Borgers May 2016

Abrupt Transitions From Low To High Firing Frequencies In Neurons And Neuronal Networks, Ryusei Melody Takeuchi, Christoph Borgers

Biology and Medicine Through Mathematics Conference

No abstract provided.


Hill's Diagrammatic Method And Reduced Graph Powers, Gregory D. Smith, Richard Hammack May 2016

Hill's Diagrammatic Method And Reduced Graph Powers, Gregory D. Smith, Richard Hammack

Biology and Medicine Through Mathematics Conference

No abstract provided.


Wilson-Cowan Coupled Dynamics In A Model Of The Cortico-Striato-Thalamo-Cortical Circuit, Anca R. Radulescu May 2016

Wilson-Cowan Coupled Dynamics In A Model Of The Cortico-Striato-Thalamo-Cortical Circuit, Anca R. Radulescu

Biology and Medicine Through Mathematics Conference

No abstract provided.


Robust Traveling Waves In Chains Of Simple Neural Oscillators, Stanislav M. Mintchev May 2016

Robust Traveling Waves In Chains Of Simple Neural Oscillators, Stanislav M. Mintchev

Biology and Medicine Through Mathematics Conference

No abstract provided.


Non-Human Primates In Neuroscience Research: The Case Against Its Scientific Necessity, Jarrod Bailey, Katy Taylor Mar 2016

Non-Human Primates In Neuroscience Research: The Case Against Its Scientific Necessity, Jarrod Bailey, Katy Taylor

Experimentation Collection

Public opposition to non-human primate (NHP) experiments is significant, yet those who defend them cite minimal harm to NHPs and substantial human benefit. Here we review these claims of benefit, specifically in neuroscience, and show that: a) there is a default assumption of their human relevance and benefit, rather than robust evidence; b) their human relevance and essential contribution and necessity are wholly overstated; c) the contribution and capacity of non-animal investigative methods are greatly understated; and d) confounding issues, such as species differences and the effects of stress and anaesthesia, are usually overlooked. This is the case in NHP …