Physical Sciences and Mathematics Commons^™

Initiation And Continuation Of Randomized Trials After The Publication Of A Trial Stopped Early For Benefit Asking The Same Study Question: Stopit-3 Study Design, Gabriela J. Prutsky, Juan Domecq, Patricia J. Erwin, Matthias Briel, Victor M. Montori, Elie A. Akl, Joerg J. Meerpohl, Dirk Bassler, Stefan Schandelmaier, Stephen D. Walter, Qi Zhou, Pablo Coello, Lorenzo Moja, Martin Walter, Kristian Thorlund, Paul Glasziou, Regina Kunz, Ignacio Ferreira-Gonzalez, Jason Busse, Xin Sun, Annette Kristiansen, Benjamin Kasenda, Osama Qasim-Agha, Gennaro Pagano, Hector Pardo-Hernandez, Gerard Urrutia, Mohammad Murad, Gordon Guyatt

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Randomized control trials (RCTs) stopped early for benefit (truncated RCTs) are increasingly common and, on average, overestimate the relative magnitude of benefit by approximately 30%. Investigators stop trials early when they consider it is no longer ethical to enroll patients in a control group. The goal of this systematic review is to determine how investigators of ongoing or planned RCTs respond to the publication of a truncated RCT addressing a similar question.

Methods/design

We will conduct systematic reviews to update the searches of 210 truncated RCTs to identify similar trials ongoing at the time of publication, or started …

Descriptive Statistical Attributes Of Special Education Datasets, Valerie Felder

Wayne State University Dissertations

ABSTRACT

Descriptive Statistical Attributes of Special Education Data Sets

by

VALERIE FELDER

December 2013

Advisor: Dr. Shlomo Sawilowsky

Major: Educational Evaluation and Research

Degree: Doctor of Philosophy

Micceri (1989) examined the distributional characteristics of 440 large-sample achievement and psychometric measures. All the distributions were found to be nonnormal at alpha = .01. Micceri indicated three factors that might contribute to a non-Gaussian error distribution in the population. The first factor is subpopulations within a target population. The second factor is ceiling effects and the third factor is treatment effects that may change the location parameter, variability, or shape of the …

Comparative Power Of The Anova, Randomization Anova, And Kruskal-Wallis Test, Jamie Gleason

Wayne State University Dissertations

The t test has been suggested to be robust to departures from normality as long as group sizes are equal and samples approach 30 or more. The F statistic has also been proposed to have the same robust qualities as the t, though researchers have suggested that because a test is robust to departures from normality, that does not necessarily make it the best test for every situation. With the increase in computing capabilities, the permutation ANOVA has been explored as an alternative to the ANOVA under non-normal conditions to rehabilitate the loss of statistical power. Since the permutation ANOVA …