Physical Sciences and Mathematics Commons^™

Aggregate Nearest Neighbor Queries In Spatial Databases, Dimitris Papadias, Yufei Tao, Kyriakos Mouratidis, Chun Kit Hui

Kyriakos MOURATIDIS

Given two spatial datasets P (e.g., facilities) and Q (queries), an aggregate nearest neighbor (ANN) query retrieves the point(s) of P with the smallest aggregate distance(s) to points in Q. Assuming, for example, n users at locations q1,...qn, an ANN query outputs the facility p belongs to P that minimizes the sum of distances |pqi| for 1 is less than or equal to i is less than or equal to n that the users have to travel in order to meet there. Similarly, another ANN query may report the point p belongs to P that minimizes the maximum distance that …

Role Of Amyloid Beta Assembly State In The Human Immune Response, Deepa Viswanathan

Dissertations

Alzheimer’s disease (AD) is a slowly progressing neurodegenerative disease that leads to dementia. Histopathological hallmarks that characterize AD are senile plaques formed by extracellular deposition of Amyloid beta (Aβ) peptide and intracellular aggregates of hyperphosphorylated tau protein. The plaques, which are found in the brain parenchyma, comprise both 40 and 42 residue Aβ. Aggregation of Aβ is an established pathogenic mechanism in AD, but little is known about the initiation of this process in vivo. Several studies have revealed significant inflammatory markers such as activated microglia and cytokines surrounding the plaques. Plaques are a hallmark of AD, but they are …

Slides: Shale And Air Quality: The View From The Other Side, Jeremy Nichols

Shale Plays in the Intermountain West: Legal and Policy Issues (November 12)

Presenter: Jeremy Nichols, Climate & Energy Program Director, WildEarth Guardians, Denver, CO

18 slides

Activation Of The Innate Immune Response By The Alzheimer's Amyloid Beta Protein Via Toll-Like Receptors, Udan Lourdes Maria

Dissertations

Alzheimer’s Disease (AD) is the most common form of neurodegenerative disease characterized by the generation and deposition of amyloid beta plaques and the formation of neurofibrillary tangles. A wealth of data now demonstrate that inflammation is a prominent feature in AD pathology and a potential therapeutic target for the treatment and prevention of the disease. The emergence of evidence linking amyloid beta protein (Aβ), the primary component of senile plaques, to inflammation has led to new insights into understanding AD pathology. Aβ, a protein fragment resulting from cleavage of human amyloid precursor protein (APP), primarily exists in two forms: a …

Small Heat-Shock Proteins Interact With A Flanking Domain To Suppress Polyglutamine Aggregation, Amy L. Roberston, Stephen J. Headey, Helen M. Saunders, Heath Ecroyd, Martin J. Scanlon, John A. Carver, Stephen P. Bottomley

Faculty of Science - Papers (Archive)

Small heat-shock proteins (sHsps) are molecular chaperones that play an important protective role against cellular protein misfolding by interacting with partially unfolded proteins on their off-folding pathway, preventing their aggregation. Polyglutamine (polyQ) repeat expansion leads to the formation of fibrillar protein aggregates and neuronal cell death in nine diseases, including Huntington disease and the spinocerebellar ataxias (SCAs). There is evidence that sHsps have a role in suppression of polyQ-induced neurodegeneration; for example, the sHsp alphaB-crystallin (αB-c) has been identified as a suppressor of SCA3 toxicity in a Drosophila model. However, the molecular mechanism for this suppression is unknown. In this …

Physical And Microbial Responses Of Dredged Sediment To Two-Soil-Stabilizing Amendments, Xanthan Gum And Guar Gum, For Use In Coastal Wetland Restoration, Lauren Land

LSU Master's Theses

In wetland sediments, organic matter provides a substrate for microbial activity. During metabolism, microbes release extracellular polymeric substances, which accumulate to bind soil particles. A similar concept can be implemented on a large scale to reduce wetland loss in Louisiana. Hypothetically, hydraulically dredged sediment can be amended with polymer and deposited on subsiding marshes as a restoration method where the polymer increases sediment stabilization until plants become established. This lab study focused on investigating the influence of natural polymer additions on particle aggregation to increase sediment stability and the effects on microbial activity. Sediments from three sites (i.e. freshwater, intermediate, …