Physical Sciences and Mathematics Commons^™

Antibiotic Resistance Of Helicobacter Pylori Strains In The United Arab Emirates And Its Relation To The Gene Associated To Gastric Cancer “Cag A Gene”, Wafa Ali Rashid Al-Tayyari

Theses

Helicobacter pylori is a flagellated corkscrew, slow growing neutrophilic gram negative ureolytic organism. It has an extraordinary ability to establish infection in human stomach that can last for years or decades. Its eradication remains an important public health challenge especially in light of broadening indications and increasing antimicrobial resistance.

AIM: i) Identification of H. pylori in UAE patients ii) Determination of the prevalence of antibiotic resistance genes (mutation in 23S rRNA gene in clarithromycin, and deletion in RdxA gene in metronidazole) among H. pylori strains isolated from U.A.E patients by using molecular methods, iii) Ascertain whether Cag A- positive H. …

Integrating Advanced Facades Intro Sustainable Office Buildings In The Emirate Of Abu Dhabi, Uae, Ahmad Omar Balhamar

Theses

Abu Dhabi emirate consume about 130 millions AED in air conditioning electricity bills, this amount is only for 700 buildings in Abu Dhabi City and 300 buildings in Musafah district. Abu Dhabi city consumes 239.70 Kw/m²/year; however Musafah district consumes 179.92 Kw/m²/year. The difference came from different in total area of glass building facades between Abu Dhabi city and Musafah district buildings. Despite the fact that Abu Dhabi is one of the hottest cities in the Gulf region, its modern office buildings are characterized by glass facades. Such a concept comes with increased air conditioning operational …

Germination Ecology Of Two Indigenous Range Grasses Lasiurus Scindicus And Panicum Turgidum, Naeema Sultan Abdullah Al-Shamisi

Theses

The utilization of indigenous forage species to replace the exotic ones could help in saving large amounts of water. The indigenous forage grasses Lasiurus scindicus and Panicum turgidum have been ranked among the plants that could tolerate drought during vegetative and reproductive stages and are currently being successfully used as fodders under experimental conditions in the UAE and in some parts of the world. However, there are no enough information about their dormancy and the environmental factors affecting their seed germination. In this study, the innate dormancy, light and temperature requirements, drought and salinity tolerances and the impact of dormancy …

Impact Of Heavy Metals On Childhood Behaviors And Development: A Uae Study, Said Yousef Ahmad Abdel Razeq

Theses

BACKGROUND: Environmental toxic metal exposure is well known to adversely affect children's development and behavior. To our knowledge, there are no studies that carefully examined this potential hazard in UAE and Gulf countries.

OBJECTIVES: The aim of this case-control study was to determine blood concentrations of 12 heavy metals in school-age children in Al Ain City. The other aim was to correlate the blood levels with developmental (e.g., learning disability) and behavioral (e.g., Attention Deficit/Hyperactivity Disorder) problems in children.

METHODS: One hundred and forty seven subjects (73 with developmental and/or behavioral disorders and 74 controls) participated in the study. The …

Workplace Privacy: An Environmental-Behaviour Analysis Of Etisalat Offices In Al-Ain, Latefa Ali Saleh Ahmad Alkuwaiti

Theses

The purpose of this study was to explore environmental quality factors in the workplace and to examine the level of job satisfaction among the employees of Etisalat Al-Ain through three main factors: visual privacy, acoustical privacy and social interaction. The theoretical and conceptual elements of the study evolved from the literature of office history, behaviour studies, building performance evaluation and job satisfaction.

Data were gathered in two stages, first phase with a population of 10 and second stage with 100 subjects of Etisalat employees, including both those working in open plan workstations and those who work in enclosed offices.

Using …

Water Demand Forecasting In Umm Al Quwain Using The Iwr-Main, Aysha Abdulla Al Mualla

Theses

Water demand forecasting has become an essential component in effective water resources planning and management. It provides valuable trigger in determining the time and the capacity for new water resources development. In the United Arab Emirates, the need for an accurate water demand forecasting becomes particularly important. The reasons for this include, and are not limited to, high temperature throughout the year, high population growth rates, and high development growth.

The main objective of this study is to forecast the water demand in UAQ for the next 25 years using the IWR-MAIN software. Two methods; namely the Constant Use Rate …

Investigation On The Minimization Of Sulfur Dioxide Emissions At Abu Dhabi Gas Liquefaction Company Limited (Adgas) And Its Impact On Ambient Air Quality, Haitham Salmeen Abdulla Babahar

Theses

The processing of sour gases within Abu Dhabi Gas Liquefaction Company (ADGAS) LNG Trains located in Das Island involves sulfur dioxide (SO₂) emissions that mainly result from fuel gas usage to produce steam and electricity, and incomplete recovery of sulfur from acid gases. ADGAS SO₂ emissions affect the ambient air quality in Das Island, and this has the potential to affect the health of the residents of the island. The aim of this work is to explore the feasible technologies to minimize SO₂ emissions from ADGAS, and study the impact of such on the ambient air …

Development And Characterization Of Sulfur Dioxide Gas Analyzer, Samira Mohamed Saeed Mohamed Baomran

Theses

Sulfur dioxide (SO₂) is considered one of the main contaminants in air because of its major contribution to acid rain and due to the major health concerns associated with exposure to high concentrations of SO₂. Hence, there has been a great interest in the determination of SO₂ because of continuous monitoring its impacts on the environment and public health. However, limited reports targeted SO₂ in gas streams.

Therefore, the primary objective of the present work was to develop affordable gas analyzer for continuous monitoring of SO₂ in gas streams. The principle of operation …

Influence Of Iron And Iron-Bearing Minerals On Soil Magnetic Properties, Suzan Marwan Ramadan Shahin

Theses

In this study, soil magnetic properties (magnetic susceptibility/ permeability) due to iron and iron bearing minerals have been evaluated by using MS2B on different percentage levels from pure iron, hematite and magnetite content at different conditions. The study shows that soil magnetic behavior has a strong dependency on grain size, temperature, water content, pH and compositional content.

Also, soil electrical behaviors have been studied due to iron and iron bearing minerals by using Impedance/ gain-phase Analyzer on different soil magnetic inclusion at different percentages. The study has established the strong effect of the magnetic inclusion on the measurements of relative …

Fluoride And Phosphate Glass Whispering Gallery Micro-Resonators, Jonathan Ward

Theses

This PhD work focuses on spherical microlasers made from commercial and experimental laser glasses. The laser light in a microsphere is confined in a region called a whispering gallery mode, which has unique properties that allow for many nonlinear effects to be observed with only sub-mW pump powers. Efficient coupling of light into the microsphere is attained by using adiabatically tapered fibres fabricated using various heating methods including a CO₂ laser, a sapphire tube furnace and electric heaters. However, the best result is obtained using a fibre pulling rig with an oxy-butane torch as the heat source. This system …

The Geometry Of The Space Of Oriented Geodesics Of Hyperbolic 3-Space, Nikos Georgiou

Theses

In this thesis we construct a Kähler structure (J, Ω, G) on the space L(H³) of oriented geodesics of hyperbolic 3-space H³ and investigate its properties. We prove that (L(H³),J) is biholomorphic to (see thesis pdf), and that the Kähler metric G is of neutral signature, conformally flat and scalar flat.

We establish that the identity component of the isometry group of the metric G on L(H³) is isomorphic to the identity component of the hyperbolic isometry group. We show that the geodesics of G correspond to ruled minimal surfaces in H3, which …

Field Induced Domain Wall Collisions In Thin Magnetic Nanowires, Andrew Kunz

Physics Faculty Research and Publications

In a two-dimensional magnetic nanowire, it is possible to engineer collisions between two domain walls put into motion by an externally applied field. We show that the topological defects that define the domain wall can be controlled to allow for both domain wall annihilation and preservation during the collisions as long as the wire remains thin. The preservation process can be used to release pinned domain walls from notches with small applied fields.

Arabidopsis Thaliana Glx2-1 Contains A Dinuclear Metal Binding Site, But Is Not A Glyoxalase 2, Pattraranee Limphong, Michael W. Crowder, Brian Bennett, Christopher A. Makaroff

Physics Faculty Research and Publications

In an effort to probe the structure and function of a predicted mitochondrial glyoxalase 2, GLX2-1, from Arabidopsis thaliana, GLX2-1 was cloned, overexpressed, purified and characterized using metal analyses, kinetics, and UV–visible, EPR, and ¹H-NMR spectroscopies. The purified enzyme was purple and contained substoichiometric amounts of iron and zinc; however, metal-binding studies reveal that GLX2-1 can bind nearly two equivalents of either iron or zinc and that the most stable analogue of GLX2-1 is the iron-containing form. UV–visible spectra of the purified enzyme suggest the presence of Fe(II) in the protein, but the Fe(II) can be oxidized over …

Mutation Of H63 And Its Catalytic Affect On The Methionine Aminopeptidase From Escherichia Coli, Sanghamitra Mitra, Brian Bennett, Richard C. Holz

Chemistry Faculty Research and Publications

In order to gain insight into the mechanistic role of a flexible exterior loop near the active site, made up of Y62, H63, G64, and Y65, that has been proposed to play an important role in substrate binding and recognition in the methionyl aminopeptidase from Escherichia coli (EcMetAP-I), the H63A enzyme was prepared. Mutation of H63 to alanine does not affect the ability of the enzyme to bind divalent metal ions. The specific activity of H63A EcMetAP-I was determined using four different substrates of varying lengths, namely, l-Met-p-NA, MAS, MGMM and MSSHRWDW. For the smallest/shortest …

A Versatile Preparation Of Geländer-Type P-Terphenyls From A Readily Available Diacetylenic Precursor, Matthew J. Modjewski, Sergey V. Lindeman, Rajendra Rathore

Chemistry Faculty Research and Publications

A series of doubly bridged p-terphenyls (4) have been synthesized utilizing a facile three-step synthesis starting from the readily available diacetylenic precursor (1) in excellent overall yields, and their structures were confirmed by 1H/13C NMR spectroscopy as well as by X-ray crystallography. The racemization barrier between the meso and chiral atropisomers of one of the derivatives of 4 was found to be ∼12 kcal/mol by variable-temperature NMR spectroscopy. The versatility of the protocol developed herein was further demonstrated by the preparation of a quadruply bridged penta-p-phenylene derivative.

A Versatile Synthesis Of Electroactive Stilbenoprismands For Effective Binding Of Metal Cations, Sergey V. Lindeman, Rajendra Rathore, Paromita Debroy

Chemistry Faculty Research and Publications

A versatile synthesis of a new class of polyaromatic receptors (stilbenoprismands) containing a Δ-shaped cavity similar to that of the π-prismand together with an intimately coupled electroactive stilbenoid moiety was accomplished via an efficient intramolecular McMurry coupling reaction. The presence of the Δ-shaped cavity in stilbenoprismands allows an efficient binding of a single silver cation as probed by ¹H NMR spectroscopy. Electron-rich stilbenoprismands undergo a ready oxidation to their highly robust cation−radical and dicationic salts. X-ray structure determination of a representative dicationic stilbenoprismand showed that the charges were largely localized on the tetraarylethylene moiety, which results in a twisting …

Octamethoxydibenzochrysene: Isolation And X-Ray Crystallographic Characterization Of A Twisted Polyaromatic Cation Radical, Tushar Navale, Linyi Zhai, Sergey V. Lindeman, Rajendra Rathore

Chemistry Faculty Research and Publications

The isolation and X-ray crystal structure determination of octamethoxydibenzochrysene (3) cation radical together with DFT calculations allow us to delineate evidence that the complex structural changes (i.e. elongation and shortening of various bonds) in a polyaromatic hydrocarbon can be predicted based on the positioning of the largest bonding and antibonding character of the HOMO.

Terphenyl Crowns: A New Family Of Receptors Containing Ethereal Canopies That Direct Potassium Cation Onto Benzenoid Platforms For Cation–Π Interactions, Ruchi Shukla, Sergey V. Lindeman, Rajendra Rathore

Chemistry Faculty Research and Publications

We have synthesized three simple and versatile terphenyl crowns (TC) receptors containing ethereal canopies that direct a potassium cation for efficient cation–π interactions as established by ¹H NMR spectroscopy and by isolation and X-ray crystallography of their K⁺ salts.

Substrate Induced Structural And Dynamics Changes In Human Phosphomevalonate Iinase And Implications For Mechanism, Andrew Lawrence Olson, Huili Yao, Timothy J. Herdendorf, Henry M. Miziorko, Supa Hannongbua, Patchareenat Saparpakom, Sheng Cai, Daniel S. Sem

Chemistry Faculty Research and Publications

Phosphomevalonate kinase (PMK) catalyzes an essential step in the mevalonate pathway, which is the only pathway for synthesis of isoprenoids and steroids in humans. PMK catalyzes transfer of the γ-phosphate of ATP to mevalonate 5-phosphate (M5P) to form mevalonate 5-diphosphate. Bringing these phosphate groups in proximity to react is especially challenging, given the high negative charge density on the four phosphate groups in the active site. As such, conformational and dynamics changes needed to form the Michaelis complex are of mechanistic interest. Herein, we report the characterization of substrate induced changes (Mg-ADP, M5P, and the ternary complex) in PMK using …

Sedimentation On A Mixed Siliciclastic/Carbonate Continental Margin Over Decadal To Millennial Timescales: Gulf Of Papua, Zahid Muhammad

LSU Doctoral Dissertations

Sediments from the Gulf of Papua were examined to estimate particle flux and sediment mass accumulation rates on multiple timescales. Patterns of sediment mass accumulation and inventory-derived 210Pb fluxes display regional variations, decreasing seaward, and along isobaths seaward from the northeastern shelf edge. The amount of terrigenous sediment load being discharged annually from the shelf and accumulating in Pandora Trough is approximately 7-14×106 tonnes. The existence of possible turbidity-current transport and deposition have been documented in deeper parts of the Gulf of Papua. High excess 210Pb fluxes estimated from seabed inventories at the shelf edge and upper slope are consistent …

Testing Of Gdcl3 Doping In Water Cherenkov Antineutrino Detectors, William Fitzgerald Coleman

LSU Doctoral Dissertations

Improved neutron and neutrino detection using water Cherenkov detectors loaded with gadolinium has been proposed for potential application in both large and small volume detectors. In this thesis, work performed to determine the effect on transparency resulting from use of GdCl3 in stainless steel constructed water Cherenkov detectors is presented. In addition, results of an experiment performed using a small volume water Cherenkov de- tector are reported. This was the first use of gadolinium loaded water to detect reactor antineutrinos.

Computational Studies Of The Properties Of Copper Oxide Clusters And The Reactions Of Phenol And Chlorinated Phenols With Copper Oxide Clusters, Gyun-Tack Bae

LSU Doctoral Dissertations

We used ab initio simulations and calculations to study the structures and stabilities of copper oxide clusters, CunOn (n=1-8) and CuOn (n=1-6). The lowest energy structures of neutral and charged copper oxide clusters were determined using primarily the B3LYP/LANL2DZ model chemistry. In CunOn clusters with n=1-8, a transition from planar to nonplanar geometries occurs at n=4. In CuOn clusters with n=1-6, all geometries of neutral, positively, and negatively charged clusters are planar or near planar structures. Selected electronic properties, including binding energies, ionization energies, and electronic affinities, were calculated and examined as a function of n. Stabilities were examined by …

Polymer-Based Microfluidic Devices For High Throughput Single Molecule Detection: Applications In Biological And Drug Discovery, Paul Ichide Okagbare

LSU Doctoral Dissertations

The realization of high throughput sample processing has become a primary ambition in many research applications with an example being high throughput screening (HTS), which represents the first step in the drug discovery pipeline. Microfluidics is a viable platform for parallel processing of biochemical reactions to increase data production rates due to its ability to generate fluidic networks with a high number of processors over small footprints suitable for optical imaging. Single-molecule detection (SMD) is another technology which has emerged to facilitate the realization of high throughput data processing afforded by its ability to eliminate sample processing steps and generate …