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Full-Text Articles in Physical Sciences and Mathematics
Synthesis Of Fluorinated Proline Analogs For The Potential Inhibition Of Proline Oxidase, Brent Hilbert
Synthesis Of Fluorinated Proline Analogs For The Potential Inhibition Of Proline Oxidase, Brent Hilbert
Honors Theses, 1963-2015
Proline oxidase is an enzyme that has been isolated from the inner membrane of rat liver mitochondria. It is the catalyst in the first step of the metabolic pathway for proline-glutamate interconversion. The enzyme is specific for L-proline which is oxidized to Æ-pyrroline- 5-carboxylic acid. 4,4- difluoro-L-proline has demonstrated irreversible inhibition of proline oxidase. Further kinetic studies of this inhibition need to be performed in order to elucidate a mechanism for the inhibition. Information regarding the site of the oxidation of proline may also be obtained from these studies. New synthetic routes to 4,4-difluoro-L-proline, and the "cis" and "trans" non- …
A Spectroscopic Study Of A Rationally Designed Zinc Binding Protein, Jill Funk
A Spectroscopic Study Of A Rationally Designed Zinc Binding Protein, Jill Funk
Honors Theses, 1963-2015
Recently, biomedical science has turned its drug research endeavors towards a philosophy known as rational drug design. Its goal is to avoid the guesswork and instead design and create the exact proteins that are needed. In order for rational drug design to be feasible, a better understanding of protein structure and function needs to be obtained. This research analyses the structure and function of a "rationally" designed mutation of the calcium binding protein parvalbumin. Parvalbumin was chosen because certain aspects of its composition facilitate analysis and in addition, there is extensive data already known about the protein. The mutation involved …