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Effects Of Corn Oil And Benzyl Acetate On Number And Size Of Azaserine-Induced Foci In The Pancreas Of Lew And F344 Rats, Daniel S. Longnecker, B D. Roebuck, Thomas J. Curphey, Evelyne Lhoste, Charles I. Coon, Denise Macmillan
Effects Of Corn Oil And Benzyl Acetate On Number And Size Of Azaserine-Induced Foci In The Pancreas Of Lew And F344 Rats, Daniel S. Longnecker, B D. Roebuck, Thomas J. Curphey, Evelyne Lhoste, Charles I. Coon, Denise Macmillan
Dartmouth Scholarship
The response of LEW and F344 strain rats to the pancreatic carcinogen azaserine was compared using the size and number of azaserine-induced acidophilic acinar cell foci and nodules as parameters in a 4-month experiment. A second experiment compared the effect of corn oil intake by gavage and dietary routes on the growth of azaserine-induced pancreatic lesions in LEW rats. A third experiment tested the activity of benzyl acetate in regard to its ability to induce acinar cell foci or to promote the growth of such foci in azaserine-treated rats. The results showed that equivalent doses of azaserine induce two to …