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Physical Sciences and Mathematics Commons

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Full-Text Articles in Physical Sciences and Mathematics

The Homeo Domain Of A Murine Protein Binds 5' To Its Own Homeo Box., Abraham Fainsod, Leonard D. Bogarad, Tarmo Ruusala, Martin Lubin Dec 1986

The Homeo Domain Of A Murine Protein Binds 5' To Its Own Homeo Box., Abraham Fainsod, Leonard D. Bogarad, Tarmo Ruusala, Martin Lubin

Dartmouth Scholarship

Nuclear protein extracts from day 12.5 mouse embryos were used to study protein binding to DNA sequences 5' of the Hox 1.5 homeo box. Embryos of this developmental stage are known to express this gene. DNA binding protein blotting and retardation gel techniques show that murine embryonic nuclear proteins specifically bind a 753-base pair (bp) DNA fragment from the region upstream of the Hox 1.5 homeo box. A fusion protein containing the Hox 1.5 homeo domain constructed in lambda gt11 also binds the same 753-bp DNA fragment. Specific binding of the fusion protein to the upstream DNA fragment shows that …


Effects Of Corn Oil And Benzyl Acetate On Number And Size Of Azaserine-Induced Foci In The Pancreas Of Lew And F344 Rats, Daniel S. Longnecker, B D. Roebuck, Thomas J. Curphey, Evelyne Lhoste, Charles I. Coon, Denise Macmillan Sep 1986

Effects Of Corn Oil And Benzyl Acetate On Number And Size Of Azaserine-Induced Foci In The Pancreas Of Lew And F344 Rats, Daniel S. Longnecker, B D. Roebuck, Thomas J. Curphey, Evelyne Lhoste, Charles I. Coon, Denise Macmillan

Dartmouth Scholarship

The response of LEW and F344 strain rats to the pancreatic carcinogen azaserine was compared using the size and number of azaserine-induced acidophilic acinar cell foci and nodules as parameters in a 4-month experiment. A second experiment compared the effect of corn oil intake by gavage and dietary routes on the growth of azaserine-induced pancreatic lesions in LEW rats. A third experiment tested the activity of benzyl acetate in regard to its ability to induce acinar cell foci or to promote the growth of such foci in azaserine-treated rats. The results showed that equivalent doses of azaserine induce two to …


A Dna Sequence Analysis Program For The Apple Macintosh, Robert H. Gross Jan 1986

A Dna Sequence Analysis Program For The Apple Macintosh, Robert H. Gross

Dartmouth Scholarship

This paper describes a new set of programs * for analyzing DNA sequences using the Apple Macintosh computer, a computer ideally suited for this kind of analysis. Because of the Macintosh interface and the availability of high quality software-only speech synthesis, these programs are truly easy to use. Instead of typing in commands, the user directs the program by making selections with the mouse, thereby eliminating most typographical and syntax errors. Output options are selected by “pressing buttons” and then clicking “OK” with the mouse. DNA sequences are confirmed by having the program speak them. The high resolution graphics on …