Physical Sciences and Mathematics Commons^™

Effects Of Shear Stress On The Distribution Of Kindlins In Endothelial Cells, Sidney V. Jones

ETD Archive

Endothelial cells (ECs) are exposed to changes in shear stress under a variety of physiological and pathological circumstances and respond by changing their shape, gene expression and cytoskeletal arrangement. Integrins are central mediators of these mechanotransduction responses of ECs and integrin function is in turn controlled by interaction of their short cytoplasmic tails with cytoplasmic binding partners. Recent studies have demonstrated the importance of the kindlin family members, known cytoplasmic tail binding proteins, as regulators of integrin function. Our lab has previously shown that kindlin-2 (K2) and kindlin-3 (K3) are both expressed and functionally significant for integrin mediated cellular events …