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Articles 1 - 6 of 6
Full-Text Articles in Physical Sciences and Mathematics
The Role Of Platelets In Hyaluronan Degradation, Sami Albeiroti
The Role Of Platelets In Hyaluronan Degradation, Sami Albeiroti
ETD Archive
Following tissue injury, platelets rapidly interact with the exposed extracellular matrix (ECM) of blood vessel wall and the surrounding tissues. Hyaluronan (HA) is a major polysaccharide component of the ECM and plays a significant role in regulating inflammation. Human platelets can degrade HA from the surfaces of activated endothelial cells into fragments capable of inducing immune responses by monocytes. In addition, platelets contain the enzyme hyaluronidse-2 (HYAL2), one of two major hyaluronidases that digest HA in somatic tissues. The deposition of HA increases in the inflamed tissues in several inflammatory diseases, including Inflammatory Bowel Disease (IBD). This study provides evidence …
Hyaluronan Rafts On Airway Epithelial Cells, Amineh M. Abbadi
Hyaluronan Rafts On Airway Epithelial Cells, Amineh M. Abbadi
ETD Archive
Many cells, including murine airway epithelial cells, respond to a variety of inflammatory stimuli by synthesizing leukocyte-adhesive hyaluronan cables that remain attached to their cell surfaces. This study shows that air-liquid interface cultures of murine airway epithelial cells (AECs) also actively synthesize and release a majority of their HA onto their ciliated apical surfaces to form a heavy chain-hyaluronan (HC-HA) matrix in the absence of inflammatory stimuli. These matrices do not resemble the rope-like HA cables, but occur in distinct sheets, or rafts, that can capture and embed leukocytes from cell suspensions. The HC-HA modification involves the transfer of heavy …
Enzyme-Based Nitric Oxide Releasing Thin Films And Scaffolds, Mutha Merenna Nuwan Bhagya Gunasekera
Enzyme-Based Nitric Oxide Releasing Thin Films And Scaffolds, Mutha Merenna Nuwan Bhagya Gunasekera
ETD Archive
Nitric oxide synthase enzyme (NOS) embedded in thin films and scaffolds, when exposed to a solution of its substrate arginine, a source of reducing equivalents, and other required ingredients of the NOS reaction, can release fluxes of nitric oxide (NO). The latter is a molecule known to counteract platelet aggregation, and thus can prevent the thrombosis cascade on the surfaces of implantable medical devices. Therefore NO antithrombogenic regimens such as active coatings and embedded scaffolds have the potential to increase the lifespan of implantable biomaterials. Layer-by-layer electrostatic adsorption allows for assembly of multi-component protein/polyelectrolytes nanostructured films. Electrospun fiber matrices may …
Magnesium As A Regulator Of Hepatic Nadph In The Hepatocyte :;Prospective Roles Of Magnesium In Diabetes And Obesity Onset, Chesinta B. Voma
Magnesium As A Regulator Of Hepatic Nadph In The Hepatocyte :;Prospective Roles Of Magnesium In Diabetes And Obesity Onset, Chesinta B. Voma
ETD Archive
No abstract provided.
The Role Of Rnase L In Thymic Homeostasis And Humoral Responses, Lin Zhang
The Role Of Rnase L In Thymic Homeostasis And Humoral Responses, Lin Zhang
ETD Archive
RNase L is highly expressed in the spleen, thymus, and multiple immune cells, suggesting that it may play an important role in the immune system against microbes. Previous studies in the lab have shown that deficiency of RNase L results in enlarged thymuses in mice at young age. However, relatively little is known about its influence on the thymic development and adaptive immunogenicity. The present Ph.D. study focuses on investigating the role of RNase L in the thymic homeostasis and humoral immune responses, thereby gaining new insights into the molecular aspects in thymocyte development, maturation and adaptive immunity.By using RNase …
Effects Of Shear Stress On The Distribution Of Kindlins In Endothelial Cells, Sidney V. Jones
Effects Of Shear Stress On The Distribution Of Kindlins In Endothelial Cells, Sidney V. Jones
ETD Archive
Endothelial cells (ECs) are exposed to changes in shear stress under a variety of physiological and pathological circumstances and respond by changing their shape, gene expression and cytoskeletal arrangement. Integrins are central mediators of these mechanotransduction responses of ECs and integrin function is in turn controlled by interaction of their short cytoplasmic tails with cytoplasmic binding partners. Recent studies have demonstrated the importance of the kindlin family members, known cytoplasmic tail binding proteins, as regulators of integrin function. Our lab has previously shown that kindlin-2 (K2) and kindlin-3 (K3) are both expressed and functionally significant for integrin mediated cellular events …