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Investigating Materials That Promote New Organic Methodology And Remediation Of Volatile Organic Compounds, Mckenzie Louise Campbell
Investigating Materials That Promote New Organic Methodology And Remediation Of Volatile Organic Compounds, Mckenzie Louise Campbell
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The need for environmentally safe reagents for the promotion of organic transformations is critical in order to reduce hazardous waste and byproducts associated with industrial-scale chemical processes. We have developed two practical methods that obviate the need for harsh oxidative and toxic brominating reagents in electrophilic halogenation reactions.
In our hands, a catalytic loading of the inexpensive, commercially available V2O5 (~$0.25/g) promotes the bromolactonization of a series of substituted alkenoic acids in isolated yields up to 97% by means of the in situ generation of bromenium (Br+) from bromide (Br−) at room temperature. This process obviates the need for molecular …
Part 1: One Minute Peptoid Synthesis, From Peptoid Oligomers To Peptoid Polymers - Part 2: Synthesis Of Creatine Derivatives, Dan Y. Dong
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Part 1:
Peptoids are isomers of peptides where the side chains are on the nitrogens instead of the carbons, which have been developed for a variety of biomedical, nano, and materials applications. Conventional peptoid synthesis uses molar concentrations of reagents and hours of reaction time per residue, thus practically limiting the lengths of peptoids. Recently, we have managed to improve yields and make peptoids of unprecedented lengths while reducing the reaction times and concentrations of reagents. Indeed, we have demonstrated that the conventional longer reaction times degrade the peptoids and lead to lower purities. In addition, by using microwave conditions, …
Development Of Sulfur And Selenium Halogen Bonded Synthons And Mechanosynthesis Of Halogen Bonded Cocrystals, Adam Michael Siegfried
Development Of Sulfur And Selenium Halogen Bonded Synthons And Mechanosynthesis Of Halogen Bonded Cocrystals, Adam Michael Siegfried
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The halogen bond, XB, has been known since the nineteenth century. A XB involves the donation of electron density from a donor such as N, O, S, or Se to an electropositive region on another atom typically iodine or bromine. XB acceptors are Lewis bases and XB donors are Lewis acids keeping terminology hydrogen bonding. The highly directional characteristic of the halogen bond paired with phenyl embrace interactions provide very useful supramolecular synthons allowing for the engineering of cocrystals with specific directional bonding motifs.
Nitrogen electron acceptors such as quinoxaline, phenazine, 4,4’-bipyridine, and 4,4’-dimethyl-2,2’-bipyridine are cocrystallized with 1,4-diiodotetrafluorobenzene (1,4-F4DIB), 1,4-difluorotetraiodobenzine …