Physical Sciences and Mathematics Commons^™

Ligand Selectivity In The Recognition Of Protoberberine Alkaloids By Hybrid-2 Human Telomeric G-Quadruplex: Binding Free Energy Calculation, Fluorescence Binding, And Nmr Experiments, Nanjie Deng, Junchao Xia, Lauren Wickstrom, Clement Lin, Kaibo Wang, Peng He, Yunting Yin, Danzhou Yang

Publications and Research

The human telomeric G-quadruplex (G4) is an attractive target for developing anticancer drugs. Natural products protoberberine alkaloids are known to bind human telomeric G4 and inhibit telomerase. Among several structurally similar protoberberine alkaloids, epiberberine (EPI) shows the greatest specificity in recognizing the human telomeric G4 over duplex DNA and other G4s. Recently, NMR study revealed that EPI recognizes specifically the hybrid-2 form human telomeric G4 by inducing large rearrangements in the 50-flanking segment and loop regions to form a highly extensive four-layered binding pocket. Using the NMR structure of the EPI-human telomeric G4 complex, here we perform molecular dynamics free …

Densities For The Repeating Decimals Problems, Nelson A. Carella

Publications and Research

Let \(p\geq 2\) be a prime, and let $1/p=0.\overline{x_{w-1} \ldots x_1x_0}$, $x_i \in \{0,1, 2, \ldots , 9\}$. The period $w\geq 1$ of the repeating decimal $1/p$ is a divisor of $p-1$. This note shows that the counting function for the number of primes with maximal period $w=p-1$ has an effective lower bound $\pi_{10}(x)=\# \{ p\leq x:\ord_p(10)=p-1 \}\gg x/ \log x$. This is a lower bound for the number of primes \(p\leq x\) with a fixed primitive root \(10 \bmod p\) for all large

numbers \(x\geq 1\). An extension to repeating decimal $1/p$ with near maximal period $w=(p-1)/r$, where $r …

Squarefree Totients P-1 And Primitive Roots, Nelson A. Carella

Publications and Research

This note determines an effective asymptotic formula for the number of squarefree totients $p-1$ with a fixed primitive root t u 6= ±1, v2

Validation Of A Lottery, Xiaona Zhou

Publications and Research

The NY Pick 4 lottery consists of four "randomly" chosen digits from 0 to 9. For this to be fair, each digit should be equally likely to occur. To determine whether this is the case, a Chi-squared goodness of fit test will be applied to historical data. This provides a quantitative way of measuring how well the observed frequency of digits matches our expectations of a fair lottery. We also explore the "Lucky Sum", which is also a part of the Pick 4. We determine which sum is most likely to occur, and what the odds of winning are if …

Deep Learning Enables Robust Assessment And Selection Of Human Blastocysts After In Vitro Fertilization, Pegah Khosravi, Ehsan Kazemi, Qiansheng Zhan, Jonas E. Malmsten, Marco Toschi, Pantelis Zisimopoulos, Alexandros Sigaras, Stuart Lavery, Lee A. D. Cooper, Cristina Hickman, Marcos Meseguer, Zev Rosenwaks, Olivier Elemento, Nikica Zaninovic, Iman Hajirasouliha

Publications and Research

Visual morphology assessment is routinely used for evaluating of embryo quality and selecting human blastocysts for transfer after in vitro fertilization (IVF). However, the assessment produces different results between embryologists and as a result, the success rate of IVF remains low. To overcome uncertainties in embryo quality, multiple embryos are often implanted resulting in undesired multiple pregnancies and complications. Unlike in other imaging fields, human embryology and IVF have not yet leveraged artificial intelligence (AI) for unbiased, automated embryo assessment. We postulated that an AI approach trained on thousands of embryos can reliably predict embryo quality without human intervention. We …

Exploring A Practical Development Of Quantum Computing, Juliano A. Everett, Andrea N. Zambrano, Carlos Aguayza

Publications and Research

Tasked with describing a Quantum architecture (Superconducting loops), we additionally explored how the chosen architecture is used, developed, and how one could get started in understanding the way in which some quantum algorithms work with this architecture through Python and IBM's tools (Qiskit and IBM Q Experience).

Results For Nonwieferich Primes, Nelson A. Carella

Publications and Research

Let $v\geq 2$ be a fixed integer, and let $x \geq 1$ be a large number. The exact asymptotic counting function for the number of nonWieferich primes $p\leq x$ such that $ v^{p-1}-1 \equiv 0 \bmod p^2$ in the interval $[1,x]$ is proposed in this note. The current results in the literature provide lower bounds, which are conditional on the $abc$ conjecture or the Erdos binary additive conjecture.

Comparative Clinical Outcomes Between Direct Oral Anticoagulants And Warfarin Among Elderly Patients With Non-Valvular Atrial Fibrillation In The Cms Medicare Population, Alpesh Amin, Oluwaseyi Dina, Allison Keshishian, Amol Dhamane, Anagha Nadkarni, Eric Carda, Cristina Russ, Lisa Rosenblatt, Jack Mardekian, Huseyin Yuce, Christine L. Baker

Publications and Research

Atrial fibrillation (AF) prevalence increases with age; > 80% of US adults with AF are aged ≥ 65 years. Compare the risk of stroke/systemic embolism (SE), major bleeding (MB), net clinical outcome (NCO), and major adverse cardiac events (MACE) among elderly non-valvular AF (NVAF) Medicare patients prescribed direct oral anticoagulants (DOACs) vs warfarin. NVAF patients aged ≥ 65 years who initiated DOACs (apixaban, dabigatran, and rivaroxaban) or warfarin were selected from 01JAN2013-31DEC2015 in CMS Medicare data. Propensity score matching was used to balance DOAC and warfarin cohorts. Cox proportional hazards models estimated the risk of stroke/SE, MB, NCO, and MACE. 37,525 …

Optical Detection And Storage Of Entanglement In Plasmonically Coupled Quantum-Dot Qubits, M. Otten, S.K. Gray, German Kolmakov V

Publications and Research

Recent proposals and advances in quantum simulations, quantum cryptography, and quantum communications substantially rely on quantum entanglement formation. Contrary to the conventional wisdom that dissipation destroys quantum coherence, coupling with a dissipative environment can also generate entanglement. We consider a system composed of two quantum-dot qubits coupled with a common, damped surface plasmon mode; each quantum dot is also coupled to a separate photonic cavity mode. Cavity quantum electrodynamics calculations show that upon optical excitation by a femtosecond laser pulse, entanglement of the quantum-dot excitons occurs, and the time evolution of the g(2) pair correlation function of the cavity photons …

Proceedings Of The Cuny Games Conference 5.0, Robert O. Duncan, Joe Bisz, Julie Cassidy, Kathleen Offenholley, Carolyn Stallard, Deborah Sturm, Anders A. Wallace

Publications and Research

The CUNY Games Network is an organization dedicated to encouraging research, scholarship and teaching in the developing field of games-based learning. We connect educators from every campus and discipline at CUNY and beyond who are interested in digital and non-digital games, simulations, and other forms of interactive teaching and inquiry-based learning. The CUNY Games Conference distills its best cutting-edge interactive presentations into a two-day event to promote and discuss game-based pedagogies in higher education, focusing particularly on non-digital learning activities that faculty can use in the classroom every day. The conference will include workshops lead by CUNY Games Organizers on …

A Multi-Criteria Gis Model For Suitability Analysis Of Locations Of Decentralized Wastewater Treatment Units: Case Study In Sulaimania, Iraq, Ako Rashed Hama, Rafea Hashim Al-Suhili, Zeren Jamal Ghafour

Publications and Research

Sulaimania is a City located in Kurdistan region in the north of Iraq. The city is facing a lack of water, and it will reach a very critical condition shortly. One of the potential solutions is to reuse the treated wastewater for non-direct human uses such as irrigation, washing, firefighting, groundwater recharging, and others. There is no sewage treatment plant in the city. The wastewater flows into a stream through some sewer outlets, and that causes big environmental issues. Decentralized wastewater treatment units (DTUs) are suggested to solve the issue. The treated wastewater will be used for the irrigation of …

Annihilator Dimers Enhance Triplet Fusion Upconversion, Andrew B. Pun, Samuel N. Sanders, Matthew Y. Sfeir, Luis M. Campos, Daniel N. Congreve

Publications and Research

Optical upconversion is a net process by which two low energy photons are converted into one higher energy photon. There is vast potential to exploit upconversion in applications ranging from solar energy and biological imaging to data storage and photocatalysis. Here, we link two upconverting chromophores together to synthesize a series of novel tetracene dimers for use as annihilators. When compared with the monomer annihilator, TIPS–tetracene, the dimers yield a strong enhancement in the triplet fusion process, also known as triplet–triplet annihilation, as demonstrated via a large increase in upconversion efficiency and an order of magnitude reduction of the threshold …

Extraction Of Acids And Bases From Aqueous Phase To A Pseudoprotic Ionic Liquid, Nikolas Patsos, Karin Lewis, Francesco Picchioni, Mark N. Kobrak

Publications and Research

We report experiments on the extraction of acids and bases from an aqueous phase to a pseudoprotic ionic liquid phase consisting of an equimolar mixture of trihexylamine and octanoic acid. We observed the extraction of a wide range of acids and bases, and investigated the mechanism of extraction in detail. Our results confirmed the observation of the Hofmeister effect in these systems reported in our previous work, where the extent of the extraction of copper salts was significantly influenced by the interactions between extracted inorganic anions and the organic phase. Our results further demonstrated that the organic layer served as …

Self-Assembled Bismuth Selenide (Bi2se3) Quantum Dots Grown By Molecular Beam Epitaxy, Marcel S. Claro, Ido Levy, Abhinandan Gangopadhyay, David J. Smith, Maria C. Tamargo

Publications and Research

We report the growth of self-assembled Bi2se3 quantum dots (QDs) by molecular beam epitaxy on GaAs substrates using the droplet epitaxy technique. The QD formation occurs after anneal of Bismuth droplets under Selenium flux. Characterization by atomic force microscopy, scanning electron microscopy, X-ray diffraction, high-resolution transmission electron microscopy and X-ray reflectance spectroscopy is presented. Raman spectra confirm the QD quality. The quantum dots are crystalline, with hexagonal shape, and have average dimensions of 12-nm height (12 quintuple layers) and 46-nm width, and a density of 8.5 × 109 cm−2. this droplet growth technique provides a means to produce topological insulator …

Allergen Sensitization And Asthma Outcomes Among World Trade Center Rescue And Recovery Workers, Belen Rojano, Erin West, Emily Federmann, Steven Markowitz, Denise Harrison, Laura Crowley, Paula Busse, Alex D. Federman, Juan P. Wisnivesky

Publications and Research

A large number of World Trade Center (WTC) rescue and recovery workers are affected by asthma. While physical and mental health comorbidities have been associated with poor asthma control in this population, the potential role of allergen sensitization is unknown. This study examined the association of indoor sensitization and exposure as a risk factor for increased asthma morbidity in WTC workers. We used data from a prospective cohort of 331 WTC workers with asthma. Sensitization to indoor allergens was assessed by measurement of antigen-specific serum immunoglobulin E (IgE) levels. We used validated tools to evaluate the exposure to indoor allergens. …

Site M0078, Lisa C. Mcneill, Donna J. Shillington, Gareth D. O. Carter, Jeremy D. Everest, Erwan Le Ber, Richard E. L. Collier, Aleksandra Cvetkoska, Gino De Gelder, Paula Diz, Mai-Linh Doan, Mary Ford, Robert L. Gawthorpe, Maria Geraga, Jack Gillespie, Romain Hemelsdaël, Emilio Herrero-Bervera, Mohammad Ismaiel, Liliane Janikian, Katerina Kouli, Shunli Li, Malka Leah Machlus, Marco Maffione, Carol Mahoney, Georgios Michas, Clint Miller, Casey W. Nixon, Sabire Asli Oflaz, Abah Philip Omale, Konstantinos Panagiotopoulos, Sofia Pechlivanidou, Marcie Purkey Phillips, Simone Sauer, Joana Seguin, Spyros Sergiou, Natalia V. Zakharova

Publications and Research

No abstract provided.

Site M0079, Lisa C. Mcneill, Donna J. Shillington, Gareth D. O. Carter, Jeremy D. Everest, Erwan Le Ber, Richard E. L. Collier, Aleksandra Cvetkoska, Gino De Gelder, Paula Diz, Mai-Linh Doan, Mary Ford, Robert L. Gawthorpe, Maria Geraga, Jack Gillespie, Romain Hemelsdaël, Emilio Herrero-Bervera, Mohammad Ismaiel, Liliane Janikian, Katerina Kouli, Shunli Li, Malka Leah Machlus, Marco Maffione, Carol Mahoney, Georgios Michas, Clint Miller, Casey W. Nixon, Sabire Asli Oflaz, Abah Philip Omale, Konstantinos Panagiotopoulos, Sofia Pechlivanidou, Marcie Purkey Phillips, Simone Sauer, Joana Seguin, Spyros Sergiou, Natalia V. Zakharova

Publications and Research

No abstract provided.

High-Resolution Record Reveals Climate-Driven Environmental And Sedimentary Changes In An Active Rift, Lisa C. Mcneill, Donna J. Shillington, Gareth D. O. Carter, Jeremy D. Everest, Robert L. Gawthorpe, Clint Miller, Marcie P. Phillips, Richard E. Ll. Collier, Aleksandra Cvetkoska, Gino De Gelder, Paula Diz, Mai-Linh Doan, Mary Ford, Maria Geraga, Jack Gillespie, Romain Hemelsdael, Emilio Herrero-Bervera, Mohammad Ismaiel, Liliane Janikian, Katerina Kouli, Erwan Le Ber, Shunli Li, Marco Maffione, Carol Mahoney, Malka L. Machlus, Georgios Michas, Casey W. Nixon, Sabire Asli Oflaz, Abah P. Omale, Kostas Panagiotopoulos, Sofia Pechlivanidou, Simone Sauer, Joana Seguin, Spyros Sergiou, Natalia V. Zakharova, Sophie Green

Publications and Research

Young rifts are shaped by combined tectonic and surface processes and climate, yet few records exist to evaluate the interplay of these processes over an extended period of early rift-basin development. Here, we present the longest and highest resolution record of sediment flux and paleoenvinronmental changes when a young rift connects to the global concerns. New results from International Ocean Discovery Program (IODP) Expedition 381 in the Corinth Rift shows 10s-100s of kyr cyclic variations in basin paleoenvironment as eustatic sea level fluctuated with respect to sills bounding this semi-isolated basin, and reveal substantial corresponding changes in the volume and …

Data Report: Summary Of Xrf Scanning On Core Sections, Iodp Expedition 381, Lisa C. Mcneill, Gino De Gelder, Malka Leah Machlus, N. Fabregas, Carol Mahoney, Sofia Pechlivanidou, Joana Seguin, Robert L. Gawthorpe, Donna J. Shillington, Gareth D. O. Carter, Jeremy D. Everest

Publications and Research

No abstract provided.

Expedition 381 Facies Associations, Lisa C. Mcneill, Donna J. Shillington, Gareth D. O. Carter, Jeremy D. Everest, Erwan Le Ber, Richard E. L. Collier, Aleksandra Cvetkoska, Gino De Gelder, Paula Diz, Mai-Linh Doan, Mary Ford, Robert L. Gawthorpe, Maria Geraga, Jack Gillespie, Romain Hemelsdaël, Emilio Herrero-Bervera, Mohammad Ismaiel, Liliane Janikian, Katerina Kouli, Shunli Li, Malka Leah Machlus, Marco Maffione, Carol Mahoney, Georgios Michas, Clint Miller, Casey W. Nixon, Sabire Asli Oflaz, Abah Philip Omale, Konstantinos Panagiotopoulos, Sofia Pechlivanidou, Marcie Purkey Phillips, Simone Sauer, Joana Seguin, Spyros Sergiou, Natalia V. Zakharova

Publications and Research

No abstract provided.

Expedition 381 Methods, Lisa C. Mcneill, Donna J. Shillington, Gareth D. O. Carter, Jeremy D. Everest, Erwan Le Ber, Richard E. L. Collier, Aleksandra Cvetkoska, Gino De Gelder, Paula Diz, Mai-Linh Doan, Mary Ford, Robert L. Gawthorpe, Maria Geraga, Jack Gillespie, Romain Hemelsdaël, Emilio Herrero-Bervera, Mohammad Ismaiel, Liliane Janikian, Katerina Kouli, Shunli Li, Malka Leah Machlus, Marco Maffione, Carol Mahoney, Georgios Michas, Clint Miller, Casey W. Nixon, Sabire Asli Oflaz, Abah Philip Omale, Konstantinos Panagiotopoulos, Sofia Pechlivanidou, Marcie Purkey Phillips, Simone Sauer, Joana Seguin, Spyros Sergiou, Natalia V. Zakharova

Publications and Research

No abstract provided.

Expedition 381 Summary, Lisa C. Mcneill, Donna J. Shillington, Gareth D. O. Carter, Jeremy D. Everest, Erwan Le Ber, Richard E. L. Collier, Aleksandra Cvetkoska, Gino De Gelder, Paula Diz, Mai-Linh Doan, Mary Ford, Robert L. Gawthorpe, Maria Geraga, Jack Gillespie, Romain Hemelsdaël, Emilio Herrero-Bervera, Mohammad Ismaiel, Liliane Janikian, Katerina Kouli, Shunli Li, Malka Leah Machlus, Marco Maffione, Carol Mahoney, Georgios Michas, Clint Miller, Casey W. Nixon, Sabire Asli Oflaz, Abah Philip Omale, Konstantinos Panagiotopoulos, Sofia Pechlivanidou, Marcie Purkey Phillips, Simone Sauer, Joana Seguin, Spyros Sergiou, Natalia V. Zakharova

Publications and Research

The primary objective of International Ocean Discovery Program Expedition 381 was to retrieve a record of early continental rifting and basin evolution from the Corinth rift, central Greece. Continental rifting is fundamental for the formation of ocean basins, and active rift zones are dynamic regions of high geohazard potential. However, the detailed spatial and temporal evolution of a complete rift system needed to understand rift development from the fault to plate scale is poorly resolved. In the active Corinth rift, deformation rates are high, the recent synrift succession is preserved and complete offshore, and earlier rift phases are preserved onshore. …

Site M0080, Lisa C. Mcneill, Donna J. Shillington, Gareth D. O. Carter, Jeremy D. Everest, Erwan Le Ber, Richard E. L. Collier, Aleksandra Cvetkoska, Gino De Gelder, Paula Diz, Mai-Linh Doan, Mary Ford, Robert L. Gawthorpe, Maria Geraga, Jack Gillespie, Romain Hemelsdaël, Emilio Herrero-Bervera, Mohammad Ismaiel, Liliane Janikian, Katerina Kouli, Shunli Li, Malka Leah Machlus, Marco Maffione, Carole Mahoney, Georgios Michas, Clint Miller, Casey W. Nixon, Sabire Asli Oflaz, Abah Philip Omale, Konstantinos Panagiotopoulos, Sofia Pechlivanidou, Marcie Purkey Phillips, Simone Sauer, Joana Seguin, Spyros Sergiou, Natalia V. Zakharova

Publications and Research

No abstract provided.

Peculiar Optical Properties Of Bilayer Silicene Under The Influence Of External Electric And Magnetic Fields, Thi-Nga Do, Godfrey Gumbs, Po-Hsin Shih, Danhong Huang, Chih-Wei Chiu, Chia-Yun Chen, Ming-Fa Lin

Publications and Research

We conduct a comprehensive investigation of the effect of an applied electric field on the optical and magneto-optical absorption spectra for AB-bt (bottom-top) bilayer silicene. The generalized tightbinding model in conjunction with the Kubo formula is efficiently employed in the numerical calculations. The electronic and optical properties are greatly diversified by the buckled lattice structure, stacking configuration, intralayer and interlayer hopping interactions, spin-orbital couplings, as well as the electric and magnetic fields (Ez ˆz & Bz ˆz ). An electric field induces spin-split electronic states, a semiconductor-metal phase transitions and the Dirac cone formations in different valleys, leading to the …

Geoarchaeological Evidence Of Middle-Age Tsunamis At Stromboli And Consequences For The Tsunami Hazard In The Southern Tyrrhenian Sea, M. Rosi, S. T. Levi, M. Pistolesi, A. Bertagnini, D. Brunelli, V. Cannavo, A. Di Renzoni, F. Ferranti, A. Renzulli, D. Yoon

Publications and Research

Large-scale landslides at volcanic islands are one of the most dangerous geological phenomena, able to generate tsunamis whose effects can propagate far from the source. However, related deposits are scarcely preserved on-land in the geologic records, and are often difficult to be interpreted. Here we show the discovery of three unprecedented well-preserved tsunami deposits related to repeated flank collapses of the volcanic island of Stromboli (Southern Italy) occurred during the Late Middle Ages. Based on carbon datings, on stratigraphic, volcanological and archaeological evidence, we link the oldest, highest-magnitude investigated tsunami to the following rapid abandonment of the island which was …

Observational Time Series For Lakes Azuei And Enriquillo: Surface Area, Volume, And Elevation, Mahrokh Moknatian, Michael Piasecki

Publications and Research

In this report, we present historical time series of surface area, volume, and elevation for lakes Azuei (Haiti) and Enriquillo (Dominican Republic). The intention is to present a history of the lakes’ levels for both bodies of water as derived from Landsat imagery that is augmented by reports and narratives that reach further back in time. We also summarize lake level time series data collected and developed through various other efforts and compare these data sets to our time series. The time series contains 45 years’ worth of data ranging from 1972 to 2017 which we developed from Landsat imagery …

Scalar Transport Over A Forest Edge With Impact Of Vertical Distribution Of Foliage And Source Types, Yulong Ma, Heping Liu, Zhenqing Liu, Chuixiang Yi, Brian Lamb

Publications and Research

The dynamics of forest-boundary-layer interactions over a forest edge have been an interesting research topic in recent years. A better understanding of edge flow has implications for the siting and interpretation of flux measurements near a forest edge. In the present study, we use large-eddy simulations with the newly developed multi-layer canopy model MCANOPY to investigate canopy flows, or more specifically scalar transfer, over a forest edge. Two important impact factors for edge flows are considered: the vertical distribution of foliage and the scalar source/sink distribution. The simulations show that both factors have non-ignored impacts on the scalar transfer over …

Episodic And Continuous Recharge Estimation From High-Resolution Well Records, Timothy Eaton

Publications and Research

Water table fluctuation (WTF) methods are a primary and well-established way to determine groundwater recharge based on the direct response of the water table to precipitation input. An emerging complexity of recharge is whether it occurs as an episodic and transient process, or a continuous steady-state process, however most studies have not focused on these short-term vs long-term timescales, in part because of a lack of data resolution. Here, high-resolution (subhourly) precipitation and water level data are analyzed for wells in the suburbs of New York City using two contrasting WTF approaches, with a common mathematical basis, that are suited …

Graded Quivers And B-Branes At Calabi-Yau Singularities, Cyril Closset, Sebastían Franco, Jirui Guo, Azeem Hasan

Publications and Research

A graded quiver with superpotential is a quiver whose arrows are assigned degrees c ∈ {0, 1, · · · , m}, for some integer m ≥ 0, with relations generated by a superpotential of degree m − 1. Ordinary quivers (m = 1) often describe the open string sector of D-brane systems; in particular, they capture the physics of D3-branes at local Calabi-Yau (CY) 3-fold singularities in type IIB string theory, in the guise of 4d N = 1 supersymmetric quiver gauge theories. It was pointed out recently that graded quivers with m = 2 and m …

New Perspectives On The Schrödinger-Pauli Theory Of Electrons: Part I, Viraht Sahni

Publications and Research

Schrödinger-Pauli (SP) theory is a description of electrons in the presence of a static electromagnetic field in which the interaction of the magnetic field with both the orbital and spin moments is explicitly considered. The theory is described from the new perspective of the individual electron via its equation of motion or ‘Quantal Newtonian’ first law. The law is in terms of ‘classical’ fields whose sources are quantum mechanical expectation values of Hermitian operators taken with respect to the system wave function. The law states that each electron experiences an external and an internal field, the sum of which vanish. …