Physical Sciences and Mathematics Commons^™

One Step Quick Detection Of Cancer Cell Surface Marker By Integrated Nife-Based Magnetic Biosensing Cell Cultural Chip, Chenchen Bao, Lei Chen, Tao Wang, Daxiang Cui, Chong Lei, Yong Zhou, Furong Tian

Articles

RGD peptides has been used to detect cell surface integrin and direct clinical effective therapeutic drug selection. Herein we report that a quick one step detection of cell surface marker that was realized by a specially designed NiFe-based magnetic biosensing cell chip combined with functionalized magnetic nanoparti- cles. Magnetic nanoparticles with 20-30 nm in diameter were prepared by coprecipitation and modified with RGD-4C, and the resultant RGD-functionalized magnetic nanoparticles were used for targeting cancer cells cul- tured on the NiFe-based magnetic biosensing chip and distinguish the amount of cell surface receptor-integrin. Cell lines such as Calu3, Hela, A549, CaFbr, HEK293 …

Decomposition Of Ireland’S Carbon Emissions From 1990-2010: An Extended Kaya Identity, Tadhg O'Mahony

Articles

In recent decades, Ireland has been an important example of a development pathway where rapid economic growth was accompanied by rising energy demand and increasing carbon emissions. Understanding the driving forces of carbon emissions is necessary for policy formulation and decomposition analysis is widely used for this purpose. This study uses an extended Kaya identity as the scheme and applies the log mean Divisia index (LMDI I) as the decomposition technique. Change in carbon emissions is decomposed from 1990 – 2010 and includes a measure of the effect of renewable energy penetration. Results illustrate that scale effects of affluence and …

Synthesis And Modification Of Octafluoro[2.2]Paracyclophane (Parylene Af4), Craig Hicks, Brendan Duffy, Gráinne Hargaden

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Parylenes are a class of organic compounds which have gained significant attention due to their application as coatings in areas such as medical devices and electronics. This review highlights the development of synthetic pathways to Octafluoro[2.2]Paracyclophane, commonly referred to as parylene AF4. Methods which have been used to functionalise AF4 are also presented.

Teaching Law And Digital Age Legal Practice With An Ai And Law Seminar: Justice, Lawyering And Legal Education In The Digital Age, Kevin D. Ashley

Articles

A seminar on Artificial Intelligence ("Al") and Law can teach law students lessons about legal reasoning and legal practice in the digital age. Al and Law is a subfield of Al/computer science research that focuses on designing computer programs—computational models—that perform legal reasoning. These computational models are used in building tools to assist in legal practice and pedagogy and in studying legal reasoning in order to contribute to cognitive science and jurisprudence. Today, subject to a number of qualifications, computer programs can reason with legal rules, apply legal precedents, and even argue like a legal advocate.

This article provides a …

A Comparison Of Raman, Ftir And Atr-Ftir Micro Spectroscopy For Imaging Human Skin Tissue Sections., Syed Mehmood Ali, Franck Bonnier, Helen Lambkin, Kathleen Flynn, V Mcdonagh, Claragh Healy, T C. Lee, Fiona Lyng, Hugh Byrne

Articles

Raman and Infrared absorption spectroscopies are compared for the analysis of human hand skin tissue sections. The tissue sections have been formalin fixed and paraffin processed, and subsequently dewaxed. Fourier Transform infrared (FTIR) spectra are preprocessed using the resonant Mie – extended multiplicative scattering algorithm to remove spectral artefacts. FTIR images of resolution 4cm^-1, analysed using K-means cluster analysis, reveal the double layer structure of the dermis and epidermis, but no further layer differentiation is achieved using the higher spatial resolution of the Attenuated Total Reflection imaging or improved spectral resolution of 2cm^-1. At comparable spectral …

The Bio-Nano-Interface In Predicting Nanoparticle Fate And Behaviour In Living Organisms: Towards Grouping And Categorising Nanomaterials And Ensuring Nanosafety By Design, Hugh Byrne, Arti Ahluwalia, Diana Boraschi,, Bengt Fadeel, Peter Gehr, Arno C. Gutleb, Michaela Kendall, Manthos Papadopoulos, Iseult Lynch

Articles

In biological media, nanoparticles acquire a coating of biomolecules (proteins, lipids, polysaccharides) from their surroundings, which reduces their surface energy and confers a biological identity to the particles. This adsorbed layer is the interface between the nanomaterial and living systems and therefore plays a significant role in determining the fate and behaviour of the nanoparticles. This review summarises the state of the art in terms of understanding the bio-nano interface and provides direction for potential future research directions and some recommendations for future priorities and strategies to support the safe implementation of nanotechnologies. The central premise is that nanomaterials must …

Raman Micro Spectroscopy Study Of The Interaction Of Vincristine With A549 Cells Supported By Expression Analysis Of Bcl-2 Protein, Haq Nawaz, Amaya Garcia, Aidan Meade, Fiona Lyng, Hugh Byrne

Articles

Understanding the interaction of anticancer drugs with model cell lines is important to elucidate the mode of action of these drugs as well as to develop cost effective and rapid screening methods. Raman spectroscopy has been demonstrated to be a valuable technique for high throughput, noninvasive analysis. The interaction of vincristine with a human lung adenocarcinoma cell line (A549)was investigated using Raman micro spectroscopy. The results were correlated with parallel measurements from the MTT cytotoxicity assay, which yielded an IC₅₀ value of 0.10 ± 0.03 μM. The Raman spectral data acquired from vincristine treated A549 cells was analysed to …

Electric Field Standing Wave Effects In Ft-Ir Transflection Spectra Of Biological Tissue Sections: Simulated Models Of Experimental Variability, Tomasz P. Wrobel, Barbara Wajnchold, Hugh Byrne, Malgorzata Baranska

Articles

The so-called electric field standing wave effect (EFSW) has recently been demonstrated to significantly distort FT-IR spectra acquired in a transflection mode, both experimentally and in simulated models, bringing into question the appropriateness of the technique for sample characterization, particularly in the field of spectroscopy of biological materials. The predicted effects are most notable in the regime where the sample thickness is comparable to the source wavelength. In this work, the model is extended to sample thicknesses more representative of biological tissue sections and to include typical experimental factors which are demonstrated to reduce the predicted effects. These include integration …

Novel Microwave Assisted Synthesis Of Zns Nanomaterials, Suresh Pillai, Michael Seery, Damian Synnott, John Colreavy, Stephen Hinder

Articles

A novel ambient pressure microwave-assisted technique is developed in which silver and indium modified ZnS is synthesised. The as prepared ZnS is characterised by X-ray diffraction, UV-Vis spectroscopy, X-ray photoelectron spectroscopy and luminescence spectroscopy. This procedure produced crystalline materials with particle sizes below 10 nm. The synthesis technique leads to defects in the crystal which induce mid energy levels in the band gap and lead to indoor light photocatalytic activity. Increasing the amount of silver causes a phase transition from cubic blende to hexagonal phase ZnS. In a comparative study, when the ZnS cubic blende is heated in a conventional …

Uv And Visible Light Activated Tio2 Photocatalysis Of 6-Hydroxymethyluracil, A Model Compound For The Potent Cyanotoxin Cylindrospermopsin, Cen Zhao, Miquel Pelaez, Dionysios Dionysiou, Suresh Pillai, John Byrne, Kevin O'Shea

Articles

TiO₂ photocatalyses of 6-hydroxymethyl uracil (6-HOMU) a model compound for the potent cyanotoxin, cylindrospermopsin (CYN), were carried out employing visible and UV irradiation using different non-metal doped TiO₂ materials, nitrogen and fluorine-TiO₂ (NF-TiO₂), phosphorus and fluorine-TiO₂ (PF-TiO₂) and sulfur-TiO₂ (S-TiO₂). The model compound was readily degraded under UV TiO₂ photocatalysis with pseudo-first-order rate constants (k) of 2.1, 1.0, and 0.44 h⁻¹ for NF-TiO₂, PF-TiO₂ and S-TiO₂, respectively. Under visible light activated (VLA), NF-TiO₂ was the most active photocatalyst, PF-TiO …

Sol-Gel Characteristics For Corrosion Resistance Of Anodised Aluminium, Michael Whelan, John Cassidy, Brendan Duffy

Articles

Conventional anodising electrolytes based on sulphuric acid, oxalic acid and phosphoric acid have been used to form nanoporous layers on AA3003-H14 and sealed with silane based sol-gel sealers. It is shown that the sol-gel chemistries have varying levels of pore penetration depending on the synthesis conditions. The extent of sol-gel penetration and pore sealing is analysed by electron microscopy and energy dispersive x-ray spectroscopy. To describe the sealing phenomena observed a sol-gel penetration and sealing rating has been proposed to explain the interactions of the sol-gels with the pores of the anodised layers. The corrosion resistance of the sol-gel sealed …

Weyl-Titchmarsh Type Formula For Periodic Schrodinger Operator With Wigner-Von Neumann Potential, Sergey Simonov, Pavel Kurasov

Articles

Schroedinger operator on the half-line with periodic background potential perturbed by a certain potential of Wigner-von Neumann type is considered. The asymptotics of generalized eigenvectors for the values of the spectral parameter from the upper half-plane and on the absolutely continuous spectrum is established. Weyl-Titchmarsh type formula for this operator is proven.

Eigenfunction Expansions Associated With The One-Dimensional Schrödinger Operator, Daphne Gilbert

Articles

We consider the form of eigenfunction expansions associated with the time-independent Schrödinger operator on the line, under the assumption that the limit point case holds at both of the infinite endpoints. It is well known that in this situation the multiplicity of the operator may be one or two, depending on properties of the potential function. Moreover, for values of the spectral parameter in the upper half complex plane, there exist Weyl solutions associated with the restrictions of the operator to the negative and positive half-lines respectively, together with corresponding Titchmarsh-Weyl functions.

Bayesian Model Selection For Exponential Random Graph Models, Alberto Caimo, Nial Friel

Articles

Exponential random graph models are a class of widely used exponential family models for social networks. The topological structure of an observed network is modelled by the relative prevalence of a set of local sub-graph configurations termed network statistics. One of the key tasks in the application of these models is which network statistics to include in the model. This can be thought of as statistical model selection problem. This is a very challenging problem---the posterior distribution for each model is often termed ``doubly intractable'' since computation of the likelihood is rarely available, but also, the evidence of the posterior …

Endomorphisms Of Abelian Groups With Small Algebraic Entropy, D. Dikranjan, Ketao Gong, P. Zanardo

Articles

We study the endomorphisms ϕ of abelian groups G having a “small” algebraic entropy h (where “small” usually means ). Using essentially elementary tools from linear algebra, we show that this study can be carried out in the group , where an automorphism ϕ with must have all eigenvalues in the open circle of radius 2, centered at 0 and ϕ must leave invariant a lattice in , i.e., be essentially an automorphism of . In particular, all eigenvalues of an automorphism ϕ with must be roots of unity. This is a particular case of a more general fact known …

Extreme Wave Events In Ireland: 14 680 Bp–2012, Laura Cooke, John M. Dudley, Frédéric Dias

Articles

The island of Ireland is battered by waves from all sides, most ferociously on the west coast as the first port of call for waves travelling across the Atlantic Ocean. However, when discussing ocean events relevant to the nation of Ire- land, one must actually consider its significantly larger designated continental shelf, which is one of the largest seabed territories in Europe. With this expanded definition, it is not surprising that Ireland has been subject to many oceanic events which could be designated as “extreme”; in this paper we present what we believe to be the first catalogue of such …

The Bench Synthesis Of Silver Nanostructures Of Variable Size And An Introductory Analysis Of Their Optical Properties, Aoife Power, Tony Betts, John Cassidy

Articles

A laboratory practical was designed for use by both undergraduate and second level students to demonstrate the synthesis and characterisation of tuneable silver colloids. It clearly illustrates the novel optical properties of silver nanoparticles compared to the bulk metal. The synthesis is both rapid and repeatable, and can be conducted on the laboratory bench at room temperature.

Spectral Multiplicity Of Selfadjoint Schrodinger Operators On Star-Graphs With Standard Interface Conditions, Sergey Simonov, Harald Woracek

Articles

We analyze the singular spectrum of selfadjoint operators which arise from pasting a finite number of boundary relations with a standard interface condition. A model example for this situation is a Schroedinger operator on a star-shaped graph with continuity and Kirchhoff conditions at the interior vertex. We compute the multiplicity of the singular spectrum in terms of the spectral measures of the Weyl functions associated with the single (independently considered) boundary relations. This result is a generalization and refinement of Theorem of I.S. Kac.

Ultrasound For Improved Crystallisation In Food Processing, N. Misra, Navneet Deora, Brijesh Tiwari, Patrick Cullen

Articles

Within the food industry, controlling crystallisation is a key factor governing food structure, texture and consumer appeal, with some foods requiring the promotion of crystallisation in a controlled manner (e.g. chocolate) and others a check (e.g. in honey). Sonocrystallisation is the application of ultrasound energy to control the nucleation of a crystallisation process. The use of power ultrasound provides a non-invasive approach to producing crystals with desired properties. Sonocrystallisation facilitates process control, primarily by modulating crystal size distribution and morphology. This paper details the governing mechanisms of sonocrystallisation. Proven and potential applications of the process in foods, including chocolates, honey, …

On The Persistence Properties Of The Cross-Coupled Camassa-Holm System, David Henry, Darryl Holm, Rossen Ivanov

Articles

In this paper we examine the evolution of solutions, that initially have compact support, of a recently-derived system of cross-coupled Camassa-Holm equations. The analytical methods which we employ provide a full picture for the persistence of compact support for the momenta. For solutions of the system itself, the answer is more convoluted, and we determine when the compactness of the support is lost, replaced instead by an exponential decay rate.

Mathematical Modelling At Secondary School: The Macsi-Clongowes Wood College Experience, J.P.F. Charpin, S. O'Hara, Dana Mackey

Articles

In Ireland, to encourage the study of STEM (science, technology, engineering and mathematics) subjects and particularly mathematics, the Mathematics Applications Consortium for Science and Industry (MACSI) and Clongowes Wood College (County Kildare, Ireland) organized a mathematical modelling workshop for senior cycle secondary school students. Participants developed simple mathematical models for everyday life problems with an open-ended answer. The format and content of the workshop are described and feedback from both students and participating teachers is provided. For nearly all participants, this workshop was an enjoyable experience which showed mathematics and other STEM components in a very positive way.

A Viewpoint Of Tanzania E-Commerce And Implementation Barriers, George S. Oreku, Fredrick Mtenzi, Al-Dahoud Ali

Articles

The growing rate of ICT utilization particularly the Internet and mobile phones has influenced at an exponential rate online interaction and communication among the generality of the populace. However, with the enormity of businesses on the Internet, Tanzania is yet to harness the opportunities for optimal financial gains. This study is exploratory in nature as it attempts to unveil the prospects of ecommerce implementation, participation, motivation and opportunity to the developing countries like Tanzania where by the domestic market is very big to ensure the growth of agricultural sector. The paper proposes to investigate the ability of consumers to purchase …

Octree-Based Indexing For 3d Point Clouds Within An Oracle Spatial Dbms, Bianca Schoen-Phelan, Abu Saleh Mohammad Mosa, Debra Laefer, Michela Bertolotto

Articles

A large proportion of today’s digital data has a spatial component. The storage and effective 10 management of such data poses particular challenges. Nowhere is this truer than with Light De-11 tection and Ranging (LiDAR), where datasets of even small geographic areas may contain sever-12 al hundred millions points. Currently available spatial information systems do not provide suita-13 ble support for 3D data. As a consequence, while a specific system can be used to store the data, 14 another has to be used to process it. Typically several software applications are used to analyze 15 and process LiDAR data, requiring …

Criminalizing Hacking, Not Dating: Reconstructing The Cfaa Intent Requirement, David Thaw

Articles

Cybercrime is a growing problem in the United States and worldwide. Many questions remain unanswered as to the proper role and scope of criminal law in addressing socially-undesirable actions affecting and conducted through the use of computers and modern information technologies. This Article tackles perhaps the most exigent question in U.S. cybercrime law, the scope of activities that should be subject to criminal sanction under the Computer Fraud and Abuse Act (CFAA), the federal "anti-hacking" statute.

At the core of current CFAA debate is the question of whether private contracts, such as website "Terms of Use" or organizational "Acceptable Use …

Using Semi-Supervised Classifiers For Credit Scoring, Kenneth Kennedy, Brian Mac Namee, Sarah Jane Delany

Articles

In credit scoring, low-default portfolios are those for which very little default history exists. This makes it problematic for financial institutions to estimate a reliable probability of a customer defaulting on a loan. Banking regulation (Basel II Capital Accord), and best practice, however, necessitate an accurate and valid estimate of the probability of default. In this article the suitability of semi-supervised one-class classification algorithms as a solution to the lowdefault portfolio problem are evaluated. The performance of one-class classification algorithms is compared with the performance of supervised two-class classification algorithms. This study also investigates the suitability of oversampling, which is …

G-Strands And Peakon Collisions On Diff(R), Darryl Holm, Rossen Ivanov

Articles

A G-strand is a map g : R x R --> G for a Lie group G that follows from Hamilton's principle for a certain class of G-invariant Lagrangians. Some G-strands on finite-dimensional groups satisfy 1+1 space-time evolutionary equations that admit soliton solutions as completely integrable Hamiltonian systems. For example, the SO(3)-strand equations may be regarded physically as integrable dynamics for solitons on a continuous spin chain. Previous work has shown that G-strands for diffeomorphisms on the real line possess solutions with singular support (e.g. peakons). This paper studies collisions of such singular solutions of G-strands when G = Diff( …