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Full-Text Articles in Physical Sciences and Mathematics
Computational Simulation And Analysis Of Neuroplasticity, Madison E. Yancey
Computational Simulation And Analysis Of Neuroplasticity, Madison E. Yancey
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Homeostatic synaptic plasticity is the process by which neurons alter their activity in response to changes in network activity. Neuroscientists attempting to understand homeostatic synaptic plasticity have developed three different mathematical methods to analyze collections of event recordings from neurons acting as a proxy for neuronal activity. These collections of events are from control data and treatment data, referring to the treatment of neuron cultures with pharmacological agents that augment or inhibit network activity. If the distribution of control events can be functionally mapped to the distribution of treatment events, a better understanding of the biological processes underlying homeostatic synaptic …
Characterization Of Calbindin Positive Interneurons Within The Ventral Horn Of The Mouse Spinal Cord, Taylor L. Floyd, David R. Ladle
Characterization Of Calbindin Positive Interneurons Within The Ventral Horn Of The Mouse Spinal Cord, Taylor L. Floyd, David R. Ladle
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Sensory-motor circuits in the spinal cord integrate sensory feedback from muscles and modulate locomotor behavior. Although we know how the sensory-motor system generally works, the main issue lies in identifying all neurons involved and understanding their interrelationships. Many interneurons contribute to sensory-motor circuits and have been well studied. For example, Renshaw cells (RC) are inhibitory interneurons that prevent motor neurons from over-activity. A distinguishing feature of RCs is that they are the only interneurons within the ventral-most region of the spinal cord expressing the calcium binding protein calbindin (CB). Recent studies have found other subpopulations of ventral horn interneurons outside …