Physical Sciences and Mathematics Commons^™

Total Synthesis Of (+/-)-Goniomitine Via A Formal Nitrile/Donor-Acceptor Cyclopropane [3 + 2] Cyclization., Christian L Morales, Brian L Pagenkopf

Chemistry Publications

The total synthesis of (+/-)-goniomitine has been accomplished in 17 linear steps with 5.2% overall yield starting from commercially available delta-valerolactam. A synthetic highlight includes the first application of a formal [3 + 2] cycloaddition between a highly functionalized nitrile and a donor-acceptor cyclopropane to prepare an indole nucleus. The use of a microwave reactor is shown to greatly improve the reaction times for two steps.

Reduction Of Esters To Ethers Utilizing The Powerful Lewis Acid Bf2otf·Oet2, Brian Pagenkopf, Nicholas A. Morra

Chemistry Publications

No abstract provided.

First Total Synthesis And Structural Reassignment Of (-)-Aplysiallene., Jian Wang, Brian L Pagenkopf

Chemistry Publications

The first total synthesis of (-)-aplysiallene has been completed in 16 steps and features a key sequential Mukaiyama aerobic oxidative cyclization to prepare the fused bis-THF core. The original stereochemical assignment has been revised as shown.

C-2/C-3 Annulation And C-2 Alkylation Of Indoles With 2-Alkoxycyclopropanoate Esters., Barbora Bajtos, Ming Yu, Hongda Zhao, Brian L Pagenkopf

Chemistry Publications

The annulation reaction between various indoles and 2-alkoxycyclopropanoate esters is reported. Both high efficiency and complete stereochemical control were observed in some cases with this annulation process. A single stereocenter on the cyclopropane controls the diastereoselective formation of up to four new stereocenters. A different reaction course was observed with 3-substituted indole substrates, and an intervening C-3 to C-2-migration process arose that gives synthetically useful C-2 alkylation indole products.

Agent Design Of Smart License Management System Using Gaia Methodology, Qian Zhao, Yu Zhou, Mark Perry

Computer Science Publications

Modern software services and data centers require a license management system to regulate the agreements that have been reached between subscriber and provider. License management helps to track usage and protect service from abuse. License agreements provide the basis for enforcement and regulation. The automation of license agreements is desired by providers and subscribers to improve transaction efficiency, give flexibility, and minimize unwanted cost.

We have proposed a framework, called SmArt (Semantic Agreement) system, that enables agreement automation in the autonomic computing context using ontology and agent technologies. This paper applies the SmArt system to the domain of license management …

Employing Intelligent Agents To Automate Sla Creation, Halina Kaminski, Mark Perry

Computer Science Publications

Service Level Agreements (SLAs) are commonly prepared and signed agreements that form the contracts between a service provider and its customers, defining the obligations and liabilities of the parties. Naturally, SLAs should reflect the business needs of both customer and supplier. SLAs are usually formed through either the adoption of a boilerplate agreement from the provider, or through a mediation/negotiation process between the parties. With the increasing adoption of software supply being implemented as a network service, such schemes are rigid or slow and costly, This paper proposes a system that the parties can use to facilitate both fast and …

Open Source Software Licensing Patterns, Halina Kaminski, Mark Perry

Computer Science Publications

No abstract provided.

Cholecystectomy Deferral In Patients With Endoscopic Sphincterotomy, Vivian Mcalister, Eric Davenport, Elizabeth Renouf

Surgery Publications

BACKGROUND: Cholecystectomy is not required in up to 64% of patients who adopt a wait-and-see policy after endoscopic clearance of common bile duct stones. Although reports of retrospective cohort series have shown a higher mortality among patients who defer cholecystectomy, it is not known if this is due to the patients' premorbid health status or due to the deferral of cholecystectomy. Randomised clinical trials of prophylactic cholecystectomy versus wait-and-see have not had sufficient power to demonstrate differences in survival.

OBJECTIVES: To evaluate the beneficial and harmful effects of cholecystectomy deferral (wait-and-see) versus elective (prophylactic) cholecystectomy in patients who have had …

Managing The Business Of Software Product Line: An Empirical Investigation Of Key Business Factors, Faheem Ahmed, Luiz Fernando Capretz

Electrical and Computer Engineering Publications

Business has been highlighted as a one of the critical dimensions of software product line engineering. This paper’s main contribution is to increase the understanding of the influence of key business factors by showing empirically that they play an imperative role in managing a successful software product line. A quantitative survey of software organizations currently involved in the business of developing software product lines over a wide range of operations, including consumer electronics, telecommunications, avionics, and information technology, was designed to test the conceptual model and hypotheses of the study. This is the first study to demonstrate the relationships between …