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Full-Text Articles in Physical Sciences and Mathematics

Probe-Level Statistical Models For Differential Expression Of Genes In Bovine Nt Studies, Jason L. Bell Jan 2009

Probe-Level Statistical Models For Differential Expression Of Genes In Bovine Nt Studies, Jason L. Bell

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

A brief introduction of microarray technology and its uses is given. This technology is commonly used in agricultural research, including research in nuclear transfer, which motivated this study. There are 3 classes of statistical models compared: probeset-level, weighted probeset-level and probe-level.

Different statistical mod els are compared on 3 spike-in experiments to assess the relative performance in identifying differentially expressed genes . A novel nested factorial model was found to outperform all other models compared in this study in one spike-in experiment, and was found to be competitive in its performance relative to the other models on the other spike-in …


Comparison Of Random Forests And Cforest: Variable Importance Measures And Prediction Accuracies, Rong Xia Jan 2009

Comparison Of Random Forests And Cforest: Variable Importance Measures And Prediction Accuracies, Rong Xia

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Random forests are ensembles of trees that give accurate predictions for regression, classification and clustering problems. The CART tree, the base learn er employed by random forests, has been criticized because of bias in the selection of splitting variables. The performance of random forests is suspect due to this criticism. A new implementation of random forests, Cforest, which is claimed to outperform random forests in both predictive power and variable importance measures , was developed based on Ctree, an implementation of conditional inference trees.

We address the underlying mechanism of random forests and Cforest in this report. Comparison of random …