Physical Sciences and Mathematics Commons^™

Stimulus-Dependent Differences In Signalling Regulate Epithelial-Mesenchymal Plasticity And Change The Effects Of Drugs In Breast Cancer Cell Lines, Joseph Cursons, Karl-Johan Leuchowius, Mark Waltham, Eva Tomaskovic-Crook, Momeneh Foroutan, Cameron P. Bracken, Andrew Redfern, Edmund J. Crampin, Ian Street, Melissa J. Davis, Erik W. Thompson

Australian Institute for Innovative Materials - Papers

Introduction: The normal process of epithelial mesenchymal transition (EMT) is subverted by carcinoma cells to facilitate metastatic spread. Cancer cells rarely undergo a full conversion to the mesenchymal phenotype, and instead adopt positions along the epithelial-mesenchymal axis, a propensity we refer to as epithelial mesenchymal plasticity (EMP). EMP is associated with increased risk of metastasis in breast cancer and consequent poor prognosis. Drivers towards the mesenchymal state in malignant cells include growth factor stimulation or exposure to hypoxic conditions.

Methods: We have examined EMP in two cell line models of breast cancer: the PMC42 system (PMC42-ET and PMC42-LA …

Citrate Synthase Activity Does Not Account For Age-Related Differences In Maximum Aerobic Performance In House Sparrows (Passer Domesticus), William A. Buttemer, C Bech, Mark A. Chappell

Faculty of Science - Papers (Archive)

We measured basal (BMR) and peak metabolic rates (PMR) in juvenile and adult House Sparrows. Juvenile birds had significantly higher BMR, but lower PMR than adult birds, despite having statistically indistinguishable body masses. We then evaluated the relation between PMR and masses of central and peripheral organs and found that pectoral muscle mass best correlated with PMR in both groups, accounting for about 35% of the variation in PMR. Because citrate synthase (CS) has such major importance in affecting the first committed step in the tricarboxylic acid cycle, we characterized CS activity levels In extracted muscles to see if this …

Differences In Soft-Sediment Macrobenthic Assemblages Invaded By Caulerpa Taxifolia Compared To Uninvaded Habitats, Justin G. Mckinnon, Paul E. Gribben, Andrew R. Davis, Dianne F. Jolley, Jeffrey T. Wright

Faculty of Science - Papers (Archive)

Caulerpa taxifolia is a habitat-forming green alga that has invaded several temperate regions worldwide. Although C. taxifolia covers large areas of soft-sediment habitat, little is known about its effects on soft-sediment invertebrate assemblages. We compared soft-sediment macroinvertebrate assemblages in 2 estuaries in southeastern Australia invaded by C. taxifolia to examine 2 main predictions: (1) areas covered with C. taxifolia will have different assemblages compared to unvegetated sediment because infauna are inhibited but epifauna are facilitated, and (2) areas with C. taxifolia will have different assemblages compared to those with native seagrasses (Halophila ovalis and Zostera capricorni) because infauna are inhibited …

Function Spaces And Multiplier Operators, R. Nillsen, S. Okada

Faculty of Informatics - Papers (Archive)

Let G denote a locally compact Hausdorff abelian group. Then a bounded linear operator T from L^2(G) into L^2(G) is a bounded multiplier operator if, under the Fourier transform on L^2(G ), for each function f in L^2(G), T(f) changes into a bounded function U times the Fourier transform of f. Then U is called the multiplier of T. An unbounded multiplier operator has a similar definition, but its domain is a dense subspace of L^2(G) and the multiplier function need not be bounded. For example, differentiation on the first order Sobolev subspace of L^2(R) is an unbounded multiplier operator …