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The Dmap-Catalyzed Acylation Of Alcohol -- A Mechanistic Study, Tania Veronica Alvarez Castro
The Dmap-Catalyzed Acylation Of Alcohol -- A Mechanistic Study, Tania Veronica Alvarez Castro
Theses and Dissertations
The mechanistic studies of Acylation of Alcohols catalyzed by 4-(N,N- Dimethyl-amino)-pyridine (DMAP) has been heavily studied in the literature. This reaction has attracted considerable interest from the synthetic and mechanistic points of view in recent years. In this research, the acylation of alcohols is prepared from cyclohexanol and acetic anhydride that is catalyzed by DMAP using triethyl amine (NEt3) as the auxiliary base and dichloromethane (DCM) as solvent. The reaction and final product will be analyzed by using gas chromatography (GC) and reaction progress kinetic analysis (RPKA). The mechanistic insights obtained in the present study should be useful for understanding …