Physical Sciences and Mathematics Commons^™

Total Synthesis Of Cytotoxic Mansouramycins From Amino Acids, Beatriz Gamez

Theses and Dissertations

Natural products produced by plants, animals, and microorganisms are of significant importance in chemistry for being major sources of molecular scaffolds essential for new drug discovery. Mansouramycins are cytotoxic bioactive compounds containing isoquinoline skeletons with substituents on the quinone and pyridine rings that may be difficult to synthesize. Synthetic processes exist for compounds B and D, however, there exists an absence of simple synthetic approaches to all four alkaloids.

This project aims to provide a general total synthetic pathway to Mansouramycins A—D from amino acids for possible use in cancer treatment via these isoquinolinequinones. Preliminary experimentation suggests there may be …

The Dmap-Catalyzed Acylation Of Alcohol -- A Mechanistic Study, Tania Veronica Alvarez Castro

Theses and Dissertations

The mechanistic studies of Acylation of Alcohols catalyzed by 4-(N,N- Dimethyl-amino)-pyridine (DMAP) has been heavily studied in the literature. This reaction has attracted considerable interest from the synthetic and mechanistic points of view in recent years. In this research, the acylation of alcohols is prepared from cyclohexanol and acetic anhydride that is catalyzed by DMAP using triethyl amine (NEt3) as the auxiliary base and dichloromethane (DCM) as solvent. The reaction and final product will be analyzed by using gas chromatography (GC) and reaction progress kinetic analysis (RPKA). The mechanistic insights obtained in the present study should be useful for understanding …

Chemical Investigation Of Avocado (Persea Americana) Seed Husk (Testa): A Waste Of Waste, Orlando A. Castillo Scheren

Theses and Dissertations

Food chemistry is a new field in the world and is currently still expanding into the types of market in which it can be tapped into. There are about 1.3 billion tons of food waste produced in 2016 in the world, and food chemistry is going to help get rid of that waste by finding new and exciting applications to the things currently considered as waste. In these products, there might be new and undiscovered drugs that can be used in the market to help treat diseases for which might not have a cure at the current moment. The avocado …

Developing A Uhf/Vhf Phased-Array Satellite Ground Station, Brent K. Cole

Theses and Dissertations

Earth-satellite communications and tracking of spacecraft are accomplished using ground stations. Traditionally, this has been achieved by using a large parabolic antenna or pair of antennas that point at a source of interest and mechanically steer the antenna(s) as the source moves throughout the sky. Phased arrays, which have often been used in radio astronomy, can provide multiple benefits when used as a ground station including fast scanning speeds across the sky, tracking and communication of multiple sources simultaneously, and significant improvements to overall gain, signal-to-noise ratio (SNR), and data bandwidth. This thesis presents a preliminary analysis of a 20-element …

Synthesis, Characterization, And Application Of Meso-Tetraphenyl Metalloporphyrin Photocatalysts Under Visible Light, Alexis Echavarria

Theses and Dissertations

The photocatalytic activity of meso-Tetraphenyl Metalloporphyrins with different metal centers was investigated. The synthesized metalloporphyrin photocatalysts was performed and analyzed using FT-IR spectroscopy, UV-VIS spectroscopy, and powder X-Ray Diffraction analysis. The synthesized TPP crystals were determined to be tetragonal crystal structure and the structure was observed in all synthesized metalloporphyrin catalysts. The Soret (B) bands, Q bands, FT-IR functional groups were identified. Reaction progress was investigated by sampling at intervals of one hour and analysis of the samples was performed using Gas Chromatography-Mass Spectrometry. GC-MS analysis was used to identify the products of the photochemical catalytic redox reactions performed under …

Neural Network Development In An Artificial Intelligence Gomoku Program, David Garcia

Theses and Dissertations

The game of Gomoku, also called Five in a Row, is an abstract strategy board game. The Gomoku program is constructed upon an algebraic monomial theory to aid values for each possible move and estimate chances for the artificial intelligence program to accomplish a winning path for each move and rounds. With the utilization of the monomial theory, winning configurations are successfully converted into monomials of variables which are represented on board positions. In the artificial intelligence program, an arduous task is how to perform the present configuration of the Gomoku game along with the past moves of the two …

On Coupled Reaction Diffusion Equations And Their Applications, Juan J. Huerta

Theses and Dissertations

Reaction-diffusion equations are nonlinear partial differential equations that have been used extensively in mathematical modeling. An interesting case in this type of equation is the Fisher-Kolmogorov system, which has been used to study a low-grade glioma, a group of primary brain tumors. In the first part of this thesis, a stochastic version of the Fisher-Kolmogorov system will be studied, and exact and numerical solutions will be presented.

The second part of this thesis will show how the speed of information propagation affects disease spread and vaccination uptake through networks in epidemics. In this model, the information reaches different people at …

Chemical Modification And In Silico Validation Of Medicinally Privileged Molecular Scaffolds As Kras And Sars-Cov-2 Protease Inhibitors, Precious M. Okwuchukwu

Theses and Dissertations

Coronavirus disease was declared a global pandemic by WHO in March 2020, cancer is the second leading cause of death by a disease. Several scientists around the world are working relentlessly to discover an effective remedy to eradicate these deadly diseases. A natural polyphenol (magnolol) has been isolated from a tree Magnolia grandiflora (family Magnoliaceae) found on UTRGV campuses. This research is focused on design of a series of chemically modified sulfonyl derivatives based on the isolated magnolol framework and other medicinally privileged molecular scaffolds framework that can effectively bind to the COVID-19 main protease, SARS- CoV-2 3CL protease …

Bivariate Markov Chain Model Of Irritable Bowel Syndrome (Ibs) Subtypes And Abdominal Pain, Ricardo Reyna Jr.

Theses and Dissertations

Researchers use stochastic models like continuous-time Markov chains (CTMC) to model progression of morbidities of public health impact, like HIV and Hepatitis C. Most of the research in that area is done for a single disease. In this research, we use a bivariate continuous-time Markov chain (CTMC) to model progression of co-morbidities. In particular, we use a bivariate CTMC to model the joint progression of Irritable Bowel Syndrome (IBS) and abdominal pain. Symptoms of IBS are known to change throughout the duration of the disorder. Hence, patients are normally asked to make a journal of the stool type, symptoms, and …

Thermal And Spectroscopic Investigations On Polymer-Based Nanofibers, Omosola Oriretan

Theses and Dissertations

Nanofibers of Poly (ethylene oxide), PEO, Poly (vinylpyrrolidone) PVP, Co-nanofiber of PEO-PVP and PEO nanocomposite of various Fullerene compositions were prepared by dissolving PEO, PVP and Fullerene in water. The Fullerene nanoparticles were added to the PEO solutions, the mixtures were homogenized under high power sonication. The PEO solutions, PVP solutions, the co-polymer solutions of PEO-PVP and the PEO -Fullerene solutions were centrifugally spun using Force spinning™ machine. The obtained nanofibers and the nanocomposites were subjected to FTIR analysis, Raman analysis and various heating and cooling cycles with heating and cooling rates ranging from 10C/min to 600C/min using differential scanning …

Effects Of Elevated Temperature On 8-Hydroxy-2'-Deoxyguanosine Expression, Dna Damage And Cellular Apoptosis In The American Oyster (Crassostrea Virginica), Md Faizur Rahman

Theses and Dissertations

Global temperature increases due to anthropogenic activities. The effects of rising temperature are well documented in aquatic organisms. The American oyster is an ideal shellfish species to study on global warming and oxidative DNA damage. In this study, We observed the effects of high temperature on heat shock protein-70 (HSP70), 8-hydroxy-2’-deoxyguanosine (8-OHdG), ssDNA, dsDNA, caspase-3 (CASP3), BAX and γH2AX, a molecular marker of DNA damage, protein expressions in gills of oysters. Immunohistochemical results showed that elevated temperatures (28 and 32°C) significantly increased HSP70, 8-OHdG, dsDNA, γH2AX, BAX and CASP3 protein expressions in gills of oysters compare to control (24°C). In …

Artificial Intelligence In A Main Warehouse In Panasonic: Los Indios, Texas, Edison Antonio Trejo Hernandez

Theses and Dissertations

The Panasonic Company warehouse is located in Los Indios Texas. The warehouse presents the limitation of the great distances between its headquarters and the Main Warehouse for supplying the branches and main customers, which requires a considerable amount of time to maintain effective communication in the inventory area. In addition, during an online review, it can be confirmed that the website is disabled, contradicting its corporate policy.

The structure of the thesis proposal is arranged in four chapters from the Introduction, Statement of the Problem and Purposes; Previous Studies and Definition of the literature; the Research Methodology and the resources …

A Targeted Adversarial Attack On Support Vector Machine Using The Boundary Line, Yessenia Rodriguez

Theses and Dissertations

In this thesis, a targeted adversarial attack is explored on a Support Vector Machine (SVM). SVM is defined by creating a separating boundary between two classes. Using a target class, any input can be modified to cross the “boundary line,” making the model predict the target class. To limit the modification, a percentage of an image of the target class is used to get several random sections. Using these sections, the input will be moved in small steps closer to the boundary point. The section that took the least number of steps to cause the model to predict the target …

Reinforcement Learning Environment For Orbital Station-Keeping, Armando Herrera Iii

Theses and Dissertations

In this thesis, a Reinforcement Learning Environment for orbital station-keeping is created and tested against one of the most used Reinforcement Learning algorithm called Proximal Policy Optimization (PPO). This thesis also explores the foundations of Reinforcement Learning, from the taxonomy to a description of PPO, and shows a thorough explanation of the physics required to make the RL environment. Optuna optimizes PPO's hyper-parameters for the created environment via distributed computing. This thesis then shows and analysis the results from training a PPO agent six times.

Effects Of Seasonal Variations And Heat Exposure On Antioxidant Expression And Redox Status In The American Oyster, Crassostrea Virginica: Field And Laboratory Studies, Md Sadequr Rahman

Theses and Dissertations

Increasing atmospheric temperatures influence physiological functions in aquatic organisms. In this study, I observed the effects of seasonal (field study) and laboratory heat exposure (16, 22, 26, and 30°C for 1-week) on prooxidant-antioxidant homeostasis in gills and digestive glands of American oyster. Histological analysis showed an increase in mucus secretion with elevated temperatures in both organs. Immunohistochemical analysis showed a significant increase of heat shock protein-70, dinitrophenyl, and 3-nitrotyrosine protein expressions with higher seasonal and laboratory temperatures indicating heat-induced oxidative and nitrosative stress. This was concomitant with gradual rise in cellular apoptosis. Interestingly, catalase and superoxide dismutase expressions also increased …

Influence Of Landscape Factors On Wildlife Presence And Road Mitigation Structure Performance, Taylor M. Hopkins

Theses and Dissertations

There are roughly 80 ocelots (Leopardus pardalis) remaining in the United States, with the entire population constrained to south Texas, with roadkill being a predominant source of mortality. To prevent additional roadkill and maintain wildlife movement, Texas Department of Transportation constructed 11.9 kilometers of wildlife exclusion fencing, 5 wildlife crossing structures (WCS), and 18 wildlife guards on State Highway 100. This thesis focused on determining the effort required for a control-impact monitoring study, the influence of biotic and abiotic factors around the roadway on wildlife presence, and the performance of mitigation structures and the road mitigation corridor. This …

Analysis Of The Functional Relationship Of Protein Kinase Families Using Phospho-Proteomics Data, David A. Parra Peña

Theses and Dissertations

As cancer research advances, Mass-spectrometry based proteomics is becoming a widely used technique for proteome characterization. Phosphoproteomics is a specific type of proteomics that characterizes proteins with the reversible post-translational modification of phosphorylation PTM), which has allowed the identifications of thousands of phosphorylation sites. These phosphorylation sites, also known as substrates, are known to interact with a protein type named kinases. Studies have shown that abnormal phosphorylation activity is related to cancer diseases. Moreover, these kinases are divided into families, based on the similarity of their catalytic domain, as this part of their amino acid sequence determines a large part …

Methods For Multi-Source Resolution In Pulsar Timing Array Based Gravitational Wave Detection, Yiqian Qian

Theses and Dissertations

With next-generation radio telescopes, namely the Five-hundred-meter Aperture Spherical Telescope(FAST) and Square Kilometer Array(SKA), scheduled to come online during this decade, hundreds of well-timed millisecond pulsars (MSPs) will be added to the Pulsar Timing Arrays (PTAs) being used currently for Gravitational Wave (GW) searches. This will greatly increase the distances to which GW sources in the very low frequency band can be detected. Among these sources will be super massive black hole binaries (SMBHBs) formed out of gigantic black holes weighing in at million to billion times the mass of our Sun. Although the large number of MSPs will improve …

Nonwovens Of Ceramic Decorated Cellulose Based Fine Fibers For Leaded Water Purification, Alejandro J. Castillo

Theses and Dissertations

Fine fibers of cellulose acetate were Forcespun and used to make nonwoven mats of cellulose. Nonwovens were activated using a solution combustion synthesis which deposited iron nitride onto fibers. Cellulose and cellulose composite mats were tested as adsorbents for lead ion in water. Cellulose showed slightly higher adsorption capacities (mg/g) up to 1300 mg/g lead loading. Adsorption data were further analyzed using several isotherms, of which the Dubinin-Raduskevich gave the best fits.

Searching For Low Frequency Fast Radio Bursts With Vlite, Suryarao Bethapudi

Theses and Dissertations

The VLITE (VLA Low Band Ionosphere and Transient Experiment; http://vlite.nrao.edu) program performs commensal observations using 16 antennas of the Very Large Array radio telescope from 320-384 MHz. The VLITE-Fast program searches for short time-scale (<100ms) transients, such as Fast Radio Bursts (FRBs), in real time and triggers recording of baseband voltages for offline imaging. Searches are made possible by a 12 node cluster, each housing GPUs for digital signal processing. A real-time Message Passing Interface (MPI)-based co-adder incoherently sums the data streams from all the antennas to boost the signal-to-noise. To undo the dispersion effects of signal propagation through the ionized interstellar medium, the co-added stream is de-dispersed and matched-filtered to search for transients. This operation is completely performed on GPUs by the software package Heimdall . A selection logic is applied to the candidates and interesting candidates with their corresponding data are processed and packaged in a binary file along with a diagnostic plot. Furthermore, a Machine Learning classification is applied on the reduced data product and, based on its decision, baseband voltages are recorded. Reduced data products collected over 126 days of on-sky operation form the VLITE-Fast Pathfinder Survey (VFPS). This pipeline has triggered on single pulses from 7 known radio pulsars. Lastly, the pipeline capabilities are tested against pure random noise and simulated injected signals.

Flexible Dye-Sensitized Solar Cells: A Study Of Photoanode And Counter Electrode Materials, Brishty Deb Choudhury

Theses and Dissertations

Compare to flat devices based on rigid substrates, fiber-shaped dye sensitized solar cells hold advantages of smaller size, light weight, facile fabrication, flexibility, and low cost, thus a promising direction for applications such as wearable electronic devices. Due to their unique photovoltaic properties, nanostructured morphologies of TiO2 on flexible substrate have been studied extensively in the recent years for applications in dye sensitized solar cells (DSSCs). Micro-structured electrode materials with high surface area can facilitate rapid charge transport and thus improve the light-to-current conversion efficiency. In the first part of this work the nano-tree morphology of the TiO2 photoanode material …

Searching For Pulsars Using The Long Wavelength Array Telescope, Keeisi A. Caballero Valdez

Theses and Dissertations

Radio pulsars are fascinating celestial objects known to display both periodic and transient behavior. Pulsars are characterized by narrow electromagnetic radiation beams which restrict the number of pulsars visible from Earth due to the necessary alignment of the radiation beam across an observer’s line of sight. Pulsars are useful tools for a broad range of applications and provide important information about the process of stellar evolution, tests for relativistic theories of gravity and the search for low-frequency gravitational waves. Over 2,500 pulsars have been observed since their initial discovery in 1967 but the search for these objects is continuously warranted. …

Unbinding Of Testosterone From The Androgen Receptor And Two Bf-3 Site Mutants, Muniruzzaman Chowdhury

Theses and Dissertations

The androgen receptor (AR) can be activated by molecules binding in the steroid binding pocket. It can also be regulated allosterically by cofactors binding to the AF-2 surface site as well as by exogenous small molecules binding to the BF-3 surface site. Recent data indicated that mutations in the BF-3 site changed the amount of the endogenous steroid needed to activate the receptor, indicating that mutations of BF-3 can cause an allosteric effect. Molecular dynamics and steered molecular dynamics simulations were used to study the allosteric effect of the mutations on AR structure and the unbinding pathways of testosterone (TES) …

Diffusion Of Falsehoods On Social Media, Kelvin Kizito King

Theses and Dissertations

Misinformation has captured the interest of academia in recent years with several studies looking at the topic broadly. However, these studies mostly focused on rumors which are social in nature and can be either classified as false or real. In this research, we attempt to bridge the gap in the literature by examining the impacts of user characteristics and feature contents on the diffusion of (mis)information using verified true and false information. We apply a topic allocation model augmented by both supervised and unsupervised machine learning algorithms to identify tweets on novel topics. We find that retweet count is higher …

Complete Integrability And Discretization Of Euler Top And Manakov Top, Austin Marstaller

Theses and Dissertations

The Euler top is a completely integrable system with physical system implications and the Manakov top is its four-dimensional extension. We are concerned about their complete integrability and the preservation of this property under a specific discretization known as the Hirota-Kimura Discretization. Surprisingly, it is not guaranteed that under any discretization the conserved quantities are preserved and therefore they must be discovered. In this work we construct the Poisson bracket and Lax pair for each system and provide the Lie algebra background needed to do such such constructions.

Development And Assessment Of An Environmental Dna (Edna) Assay For The Rio Grande Siren And Review Of Edna Metabarcoding Applications, Krista M. Ruppert

Theses and Dissertations

Environmental DNA (eDNA) assays have become a major aspect of amphibian surveys in the past decade. These methods are highly sensitive, making them well-suited for monitoring rare and cryptic species. Current efforts to study the Rio Grande Siren in south Texas have been hampered due to the cryptic nature of these aquatic salamanders. Arid conditions further add to the difficulty in studying this species, as many water bodies they inhabit are ephemeral, sometimes constraining sampling efforts to a short window after heavy rain. Additionally, sirens are known to cease activity and reside underground when ponds begin to dry or as …

Pipe Flow Of Newtonian And Non-Newtonian Fluids, Erick Sanchez

Theses and Dissertations

We consider an incompressible, viscous fluid in a cylindrical pipe. We obtain velocity profile for both Newtonian fluid and non-Newtonian fluids such as shear-thinning, shear- thickening and Bingham plastic fluids. The flow is governed by the equation of continuity (conservation of mass) and the momentum equation. After presenting the governing system in the cylindrical coordinate system and assuming that the flow is due to the pressure drop and wall shear stress, we derive the expressions for the velocity component in the axial direction for these cases. Some computational results of the velocity profiles for various cases are presented. We will …

Creativity And Engagement In Ideas Crowdsourcing: A Situation Awareness Perspective, James Gitau Wairimu

Theses and Dissertations

This dissertation investigates the influence of performance feedback in user motivation and creativity development in idea crowdsourcing engagement. Creativity occurs when users of idea crowdsourcing communities engage in direct and indirect interactions that expose them to a pool of knowledge that enhances their cognitive development leading to the contribution of novel ideas for innovation in organizations. Additionally, participant motivation to engage in ideas crowdsourcing is increased through rewards and conditions that make the ideation process more inclusive and enjoyable. An idea network design is developed by applying social network analysis principles. The idea network design consists of mechanisms for motivating …

Predicting Patterns Of Heavy Metal Contamination In Rio Grande Valley Agricultural Soils, Joy Z. Youwakim

Theses and Dissertations

The Rio Grande Valley of Texas is the statewide leader in the production of produce and grains and is irrigated by the Rio Grande River, in which heavy metal contaminants have been documented by both the International Boundary Water Commission and the United States Geological Survey. This work attempts to observe and document patterns of heavy metal pooling in order to mitigate the increased risk of contamination due to urbanization. We hypothesize that relationships exist between heavy metal content and proximity to roads, land use, and soil type. This research tests these relationships through soil sampling and atomic absorption spectrometry …

The Application Of Advanced Technologies For Agriculture And Rangeland Management, Matthew D. Kutugata

Theses and Dissertations

This project demonstrates two applications of remote sensing in agricultural and rangeland environments. In the first, an unmanned aerial system (UAS) equipped with a multi-spectral sensor was used to estimate canopy cover across four different cover crop trials at four time periods. In the second, a local database of stationary camera trap images of wildlife was used to train a convolutional neural network to automatically catalogue images by identifying the animal in those images. Both projects aimed to provide an example of how remote sensing platforms and machine learning techniques can facilitate the rapid collection and processing of large-scale field …