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Synthesis And In Vitro Antimicrobial And Cytotoxicity Activities Of 2-[(2-Nitro-1-Phenylalkyl)Thio]Benzoic Acid Derivatives, Mehtap Gökçe, Semra Utku, Erdoğan Berçi̇n, Berri̇n Özçeli̇k, Taner Karaoğlu, Ni̇ngur Noyanalpan

Turkish Journal of Chemistry

In this research 14 compounds were tested for their antimicrobial activity. The synthesis of 7 compounds corresponding to 2-[(2-nitro-1-phenyl-propyl)thio]benzoic acids 4 has not been reported before and 7 compounds corresponding to 2-[(2-nitro-1-phenyl-ethyl) thio]benzoic acid 3 were reported by our research group. The antibacterial activity of the title compounds was evaluated by 2 Gram (+) (Staphylococcus aureus, Bacillus subtilis) and 2 Gram (-)(Pseudomonas aeruginosa, Escherichia coli) microorganisms. The antifungal activity of the compounds was also determined against yeast-like fungi (Candida albicans, C. krusei). For antibacterial activity, ampicillin and for antifungal activity, fluconazole and ketoconazole have been used as reference compounds. All …