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Full-Text Articles in Physical Sciences and Mathematics
Synthesis And Antimicrobial Activity Of Novel 2-[4-(1h-Benzimidazol-1-Yl)Phenyl]-1h-Benzimidazoles, Mehmet Alp, Ali̇ Hakan Göker, Nurten Altanlar
Synthesis And Antimicrobial Activity Of Novel 2-[4-(1h-Benzimidazol-1-Yl)Phenyl]-1h-Benzimidazoles, Mehmet Alp, Ali̇ Hakan Göker, Nurten Altanlar
Turkish Journal of Chemistry
A new class of 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles (13--22) were synthesized via cyclocondensation reaction of the substituted 1,2-phenylenediamines (1, 4--12) and 1-(4-formylpheny)-1H-benzimidazole (3). The synthesized compounds were evaluated for antibacterial and antifungal activities against S. aureus, methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans by the tube dilution method. Compounds 13, 15, 18, 20, and 21 have moderate antifungal activity against C. albicans.
Convenient Method For Synthesis Of Various Fused Heterocycles Via Utility Of 4-Acetyl-5-Methyl-1-Phenyl-Pyrazole As Precursor, Sobhi Mohamed Gomha, Ahmad Sami Shawali, Abdou Osman Abdelhamid
Convenient Method For Synthesis Of Various Fused Heterocycles Via Utility Of 4-Acetyl-5-Methyl-1-Phenyl-Pyrazole As Precursor, Sobhi Mohamed Gomha, Ahmad Sami Shawali, Abdou Osman Abdelhamid
Turkish Journal of Chemistry
A new, less expensive, solvent-free procedure was developed for the synthesis of some new derivatives of various fused heterocyclic ring systems, namely azolopyridazine, azolotriazine, azinotriazine, thienopyridine, and pyrazolopyridine. The structures of the products prepared were established by their spectral data and elemental analyses. Eight compounds were evaluated for their in vitro antimicrobial activity. Some of the tested compounds exhibited moderate to significant antibacterial and antifungal activities.