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Full-Text Articles in Physical Sciences and Mathematics
Role Of Non-Muscle Myosin Ii In Hs578t/Hs578ts(I)8 Triple Negative Breast Cancer Progression, Shimara Gunawardana
Role Of Non-Muscle Myosin Ii In Hs578t/Hs578ts(I)8 Triple Negative Breast Cancer Progression, Shimara Gunawardana
Electronic Theses and Dissertations
Loss of cell-cell adhesion and migration are prerequisites for the formation of metastases. These events are mediated by changes in the actomyosin cytoskeleton. Nonmuscle myosin II (NMII) belongs to the myosin superfamily of motor proteins which binds to actin and controls actin cross-linking and contraction, however its role and regulation in cell-adhesion and migration remains poorly understood. In this study, we report that associations of α5β1integrin receptors and Ncadherins with NMII isoforms NM-IIA and NMII-B correlate with increased cell-cell adhesion and reduced migratory behavior of the parental Hs578T cells of the Hs578T/Hs578Ts(i)8 triple-negative breast cancer progression model. Using blebbistatin, a …