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Full-Text Articles in Physical Sciences and Mathematics

Impacts Of Diverse Crop Rotations And Integrated Crop-Livestock System On Soil Quality In South Dakota, Atilla Polat Jan 2018

Impacts Of Diverse Crop Rotations And Integrated Crop-Livestock System On Soil Quality In South Dakota, Atilla Polat

Electronic Theses and Dissertations

Crop diversification can be beneficial in improving soil quality parameters. Diverse crop rotations and integrated crop-livestock systems (ICLS), are two examples of crop diversification used in this study to assess soil quality. The objectives of this study were to: (i) assess the impacts of diverse rotations on soil quality parameters, and (ii) assess the impacts of low and high stocking density on soil quality parameters. Both of the studies were conducted separately and are presented as two different chapters. To accomplish objective (i), a long-term experiment was selected which was established near Brookings, South Dakota, USA at USDA-ARS lab in …


A Comprehensive Analysis Of Aromatic-Proton Mediated Hydrogen Bonds, Mona S. Alshamrani Jan 2018

A Comprehensive Analysis Of Aromatic-Proton Mediated Hydrogen Bonds, Mona S. Alshamrani

Electronic Theses and Dissertations

Hydrogen bonds play critical role in folding, structure and recognition of biological macromolecules (e.g., proteins, RNA, DNA). In addition to classical hydrogen bonds (e.g., ─OH---O=, ─OH---O─, ─NH---O─ etc.), structural analysis of protein and nucleic acids, almost a decade ago, showed that hydrogen bonds (e.g., CH---O) with hydrogen atoms on aliphatic carbon atoms (hereafter, aliphatic-protons) also play very important role in the structure and function of biomolecules. Even though, protons of aromatic ring systems (hereafter, aromatic-protons) are more polar than the aliphatic-protons, systematic analysis of hydrogen bonds of aromatic-protons have not been carried out. Therefore, I carried out a systematic analysis …


Location Optimization Of A Coal Power Plant To Balance Coal Supply And Electric Transmission Costs Against Plant’S Emission Exposure, Najam Khan Jan 2018

Location Optimization Of A Coal Power Plant To Balance Coal Supply And Electric Transmission Costs Against Plant’S Emission Exposure, Najam Khan

Electronic Theses and Dissertations

This research is focused on developing a location analysis methodology that can minimize the pollutant exposure to the public while ensuring that the combined costs of electric transmission losses and coal logistics are minimized. Coal power plants will provide a critical contribution towards meeting electricity demands for various nations in the foreseeable future. The site selection for a new coal power plant is extremely important from an investment point of view. The operational costs for running a coal power plant can be minimized by a combined emphasis on placing a coal power plant near coal mines as well as customers. …


Comparison Of Historical Precipitation For Aberdeen, Ipswich, And Eureka, South Dakota, Uday Singh Kshatriya Jan 2018

Comparison Of Historical Precipitation For Aberdeen, Ipswich, And Eureka, South Dakota, Uday Singh Kshatriya

Electronic Theses and Dissertations

The availability of water resources varies from time to time with the climate conditions. Keeping track of climate conditions would eventually benefit for the future predictions. The objective of this research was to compare and contrast the climate especially for Aberdeen, Ipswich and Eureka, South Dakota utilizing the historical monthly precipitation records and to develop the techniques that are reliable to estimate the missing data. For these necessary statistical analyses were performed using the monthly precipitation data from High Plains Regional Climate Center (HPRCC) for the annual and 8-Year periods for Aberdeen, Ipswich and Eureka, South Dakota. 63 water years …


Aspects Of White-Tailed Deer Ecology And Management: Effects Of Imidacloprid And An Evaluation Of Management At Great Swamp National Wildlife Refuge, Elise Hughes Berheim Jan 2018

Aspects Of White-Tailed Deer Ecology And Management: Effects Of Imidacloprid And An Evaluation Of Management At Great Swamp National Wildlife Refuge, Elise Hughes Berheim

Electronic Theses and Dissertations

White-tail deer (Odocoileus virginianus) are an economically and recreationally important species throughout their range, and understanding their ecology to implement beneficial management techniques is invaluable. This thesis focused on two studies 1) the effect of Imidacloprid on adult female and fawn physiology and 2) an evaluation of techniques to monitor white-tailed deer at Great Swamp National Wildlife Refuge (GSNWR). Imidacloprid, a widely-used pesticide, has been linked to lethal and sub-lethal effects in insects and small vertebrates, however, no research has been conducted on white-tailed deer. Twenty captive pregnant adult female and subsequent fawns housed at the South Dakota …


Satellite Remote Sensing Of Woody And Herbaceous Leaf Area For Improved Understanding Of Forage Resources And Fire In Africa, Milkah Njoki Kahiu Jan 2018

Satellite Remote Sensing Of Woody And Herbaceous Leaf Area For Improved Understanding Of Forage Resources And Fire In Africa, Milkah Njoki Kahiu

Electronic Theses and Dissertations

In sub-Saharan Africa (SSA) tree-grass systems commonly referred to as savannas dominating drylands, play a critical role in social, cultural, economic and environmental systems. These coupled natural-human systems support millions of people through pastoralism, are important global biodiversity hotspots and play a critical role in global biogeochemical cycles. Despite the importance of SSA savannas, they have been marginalized for years as most governments neglect dryland resources in favor of agricultural research and development assistance. Hence, lack of spatially and temporally accurate information on the status and trends in savanna resources has led to poor planning and management. This scenario calls …


Black-Tailed Prairie Dog (Cynomys Ludovicianus) State-And-Transition Model For Loamy Ecological Sites In Mlra 62 In Custer State Park, South Dakota, Mark R. Hendrix Jan 2018

Black-Tailed Prairie Dog (Cynomys Ludovicianus) State-And-Transition Model For Loamy Ecological Sites In Mlra 62 In Custer State Park, South Dakota, Mark R. Hendrix

Electronic Theses and Dissertations

Black-tailed prairie dogs (Cynomys ludovicianus) are native burrowing rodents that occupy large areas in the shortgrass and mixed-grass prairies of the Northern Great Plains. They are an important component of these prairie systems due to their impacts on plant communities. Currently State-and-Transition models (STMs) for grassland Ecological Site Descriptions (ESDs) address grazing by livestock as a major factor affecting states and phases within states. Impacts from other grazers, such as prairie dogs, are either not addressed directly, or are included only in a transition to a generalized early seral state. There are, however, dramatic differences in plant communities …


Evaluation Of Methods Used To Improve Grasslands As Ring-Necked Pheasant (Phasianus Colchicus) Brood Habitat, Mandy Orth Jan 2018

Evaluation Of Methods Used To Improve Grasslands As Ring-Necked Pheasant (Phasianus Colchicus) Brood Habitat, Mandy Orth

Electronic Theses and Dissertations

Management practices designed for upland game species often focus on nest survival and hen winter survival due to the importance of these life history stages on population vital rates. However, chick survival is an important component of gallinaceous bird population dynamics, but it is poorly understood and often tends to be overlooked. Ideal brood habitat not only provides open understory for easy movement and canopy cover for protection, but also provides an abundance of arthropod foods for chicks. It has been hypothesized that restricted movement of chicks through thick vegetation in unmanaged grasslands results in lower brood survival rates. Research …


Wi-Fi Finger-Printing Based Indoor Localization Using Nano-Scale Unmanned Aerial Vehicles, Appala Narasimha Raju Chekuri Jan 2018

Wi-Fi Finger-Printing Based Indoor Localization Using Nano-Scale Unmanned Aerial Vehicles, Appala Narasimha Raju Chekuri

Electronic Theses and Dissertations

Explosive growth in the number of mobile devices like smartphones, tablets, and smartwatches has escalated the demand for localization-based services, spurring development of numerous indoor localization techniques. Especially, widespread deployment of wireless LANs prompted ever increasing interests in WiFi-based indoor localization mechanisms. However, a critical shortcoming of such localization schemes is the intensive time and labor requirements for collecting and building the WiFi fingerprinting database, especially when the system needs to cover a large space. In this thesis, we propose to automate the WiFi fingerprint survey process using a group of nano-scale unmanned aerial vehicles (NAVs). The proposed system significantly …


Lignin Depolymerization: Mechanistic Analysis, Optimization And Application, Eric Michael Nagel Jan 2018

Lignin Depolymerization: Mechanistic Analysis, Optimization And Application, Eric Michael Nagel

Electronic Theses and Dissertations

Lignin is the most abundant aromatic biopolymer and is a potential source for phenolic chemical feedstocks. Lignin is composed of phenolic units connected by more than eight different linkages, the most common being β-O-4 which constitutes 50-60%. The hydrothermal decomposition of a guaiacol based β-O-4 lignin dimer was studied under neutral and basic conditions to elucidate the mechanism of β-O-4 bond cleavage and the formation of downstream products. Phenol-carbonyl condensation and vinyl-ether formation were shown to be the primary causes for low monomer yields under the tested conditions. Three Ni catalyst systems, Ni/C + H2, Ni/C-Zn, and Ni/Zn, …


Application Of Drainage Water Management And Saturated Buffers For Conservation Drainage In South Dakota, Abhinav Sharma Jan 2018

Application Of Drainage Water Management And Saturated Buffers For Conservation Drainage In South Dakota, Abhinav Sharma

Electronic Theses and Dissertations

Edge of field practices such as drainage water management (DWM) and saturated buffers can reduce nutrient transport from croplands to surface waterbodies. DWM uses stackable weir boards in a control structure to manipulate the water table depth throughout the cropping season and reduce the amount of nutrient rich water draining out from the field. Saturated buffers, on the other hand, use a control structure to divert water draining out from the cropland to a vegetative strip via a subsurface tile installed parallel to a waterway. For the saturated buffer systems, a combination of natural denitrification, nitrogen mineralization, and plant uptake …


A Development Of Travel Time Equation For Overland Flow As Affected By Vegetation, Naga Vara Prasad Ganti Jan 2018

A Development Of Travel Time Equation For Overland Flow As Affected By Vegetation, Naga Vara Prasad Ganti

Electronic Theses and Dissertations

In overland flow water research, travel time is a significant parameter used in estimating peak discharge in channels or rivers. Overland flow is assumed to be in turbulent condition to estimate travel time using Manning’s Velocity Equation (MVE). When the flow is in a laminar condition, Grismer’s Laminar Mean Velocity Equation (GLMVE) is applied but fails to consider the roughness parameter. A review of the literature shows numerous equations for overland travel time, but there is no known equation that determines the mean velocity of overland flow under laminar condition with a roughness coefficient or other coefficient related to the …


Evaluating E. Coli Particle Attachment And The Impact On Transport During High Flows, Louis Amegbletor Jan 2018

Evaluating E. Coli Particle Attachment And The Impact On Transport During High Flows, Louis Amegbletor

Electronic Theses and Dissertations

Fecal indicator bacteria, including E. coli, are the leading cause of water quality impairments within assessed waters in the United States. The source of E. coli includes WWTP, leaking sewers, animal manure, wildlife, livestock, and stream bed sediment. Storm events contribute to bacteria loading within waters through wash-in of land sources of bacteria and resuspension of bacteria within sediments. Bacteria introduced into the water column are either attached to particles or are unattached (or free-living). The goal of this study was to examine the attachment of E. coli to different particle sizes, including their impact on contributing to water …


Biomass Burning In The Conterminous United States: A Comparison And Fusion Of Active Fire Observations From Polar-Orbiting And Geostationary Satellites For Emissions Estimation, Fangjun Li Jan 2018

Biomass Burning In The Conterminous United States: A Comparison And Fusion Of Active Fire Observations From Polar-Orbiting And Geostationary Satellites For Emissions Estimation, Fangjun Li

Electronic Theses and Dissertations

Biomass burning is an important source of atmospheric greenhouse gases and aerosol emissions that significantly influence climate and air quality. Estimation of biomassburning emissions (BBE) has been limited to the conventional method in which parameters (i.e., burned area and fuel load) can be challenging to quantify accurately. Recent studies have demonstrated that the rate of biomass combustion is a linear function of fire radiative power (FRP), the instantaneous radiative energy released from actively burning fires, which provides a novel pathway to estimate BBE. To obtain accurate and timely BBE estimates for near real-time applications (i.e., air quality forecast), the satellite …


Statistical Algorithms And Bioinformatics Tools Development For Computational Analysis Of High-Throughput Transcriptomic Data, Adam Mcdermaid Jan 2018

Statistical Algorithms And Bioinformatics Tools Development For Computational Analysis Of High-Throughput Transcriptomic Data, Adam Mcdermaid

Electronic Theses and Dissertations

Next-Generation Sequencing technologies allow for a substantial increase in the amount of data available for various biological studies. In order to effectively and efficiently analyze this data, computational approaches combining mathematics, statistics, computer science, and biology are implemented. Even with the substantial efforts devoted to development of these approaches, numerous issues and pitfalls remain. One of these issues is mapping uncertainty, in which read alignment results are biased due to the inherent difficulties associated with accurately aligning RNA-Sequencing reads. GeneQC is an alignment quality control tool that provides insight into the severity of mapping uncertainty in each annotated gene from …


Variable Selection Techniques For Clustering On The Unit Hypersphere, Damon Bayer Jan 2018

Variable Selection Techniques For Clustering On The Unit Hypersphere, Damon Bayer

Electronic Theses and Dissertations

Mixtures of von Mises-Fisher distributions have been shown to be an effective model for clustering data on a unit hypersphere, but variable selection for these models remains an important and challenging problem. In this paper, we derive two variants of the expectation-maximization framework, which are each used to identify a specific type of irrelevant variables for these models. The first type are noise variables, which are not useful for separating any pairs of clusters. The second type are redundant variables, which may be useful for separating pairs of clusters, but do not enable any additional separation beyond the separability provided …


Quantifying Potential Long-Term Changes In Erosion, Discharge, And Total Suspended Solids Resulting From Agricultural Land Use Change In South Dakota, Hector Manuel Menendez Iii Jan 2018

Quantifying Potential Long-Term Changes In Erosion, Discharge, And Total Suspended Solids Resulting From Agricultural Land Use Change In South Dakota, Hector Manuel Menendez Iii

Electronic Theses and Dissertations

South Dakota is a mosaic of grasslands, wetlands, and cropland. A continuing shift from grassland to cropland has occurred over the past decade and is expected for the next 50 years. Rate of future conversion may vary greatly in response to regulatory, economic, and social factors. Concern has risen over environmental consequences associated with land conversion, which include but are not limited to changes in rill and sheet erosion rates from cultivated soils, stream and river discharge, and water quality. Quantifying future changes for these three externalities is important to understand the possible long-term consequences of complex grassland conversion decisions …


Mapping And Risk Assessment Of Juniper Encroachment Into A Prairie Landscape, Kyle D. Kaskie Jan 2018

Mapping And Risk Assessment Of Juniper Encroachment Into A Prairie Landscape, Kyle D. Kaskie

Electronic Theses and Dissertations

Juniper encroachment is a considerable threat to the prairie ecosystems of the Great Plains because it has the potential to alter native grasslands by changing soil characteristics, limiting herbaceous biomass, and hindering native community regeneration. Accurate maps of juniper cover and predictions of areas at risk for future expansion are needed to support proactive management measures. Therefore, our objectives are to: (1) Develop a practical workflow for large-scale juniper mapping using Landsat 8 Operational Land Imager (OLI) imagery and partial unmixing techniques, (2) Compare the classification accuracies from the resulting map based on different juniper density thresholds and different types …


Modeling Soil Organic Carbon In Select Soils Of Southeastern South Dakota, Shaina Westhoff Jan 2018

Modeling Soil Organic Carbon In Select Soils Of Southeastern South Dakota, Shaina Westhoff

Electronic Theses and Dissertations

Soil organic matter (SOM) is composed of living biomass, dead plant and animal residues, and humus. Humus is a class of complex, organic molecules that are largely responsible for improving soil water holding capacity, nutrient mineralization, nutrient storage, and other critical soil functions. Soil organic carbon (SOC) accounts for approximately 60 percent of SOM and thus SOC is recognized as a strong indicator of soil health. Land use changes and intense cultivation of arable soils in the United States over the past century have led to large decreases in SOM. The objective of this research was to develop a multiple …


Quantifying The Short-Term Impacts Of Cover Crops And Grazing On Soil Health Under An Integrated Crop-Livestock System In South Dakota, Vishal Seth Jan 2018

Quantifying The Short-Term Impacts Of Cover Crops And Grazing On Soil Health Under An Integrated Crop-Livestock System In South Dakota, Vishal Seth

Electronic Theses and Dissertations

Cover crops and grazing under Integrated Crop-Livestock System (ICLS) can impact the rhizosphere nutrient cycling and may have potential to increase the long-term sustainability and economic profitability of agricultural production system. In South Dakota, crop production practices and livestock husbandry are both common which provide the opportunity for ICLS to be successful in this region. However, little is known about the impacts of the cover crops and grazing under ICLS on soil properties in this region. The present study was conducted at South Dakota State University Research Farm (44°20'34.8"N, 96°48'14.8"W), Brookings, SD, to quantify the impacts of cover crops and …


Role Of Non-Muscle Myosin Ii In Hs578t/Hs578ts(I)8 Triple Negative Breast Cancer Progression, Shimara Gunawardana Jan 2018

Role Of Non-Muscle Myosin Ii In Hs578t/Hs578ts(I)8 Triple Negative Breast Cancer Progression, Shimara Gunawardana

Electronic Theses and Dissertations

Loss of cell-cell adhesion and migration are prerequisites for the formation of metastases. These events are mediated by changes in the actomyosin cytoskeleton. Nonmuscle myosin II (NMII) belongs to the myosin superfamily of motor proteins which binds to actin and controls actin cross-linking and contraction, however its role and regulation in cell-adhesion and migration remains poorly understood. In this study, we report that associations of α5β1integrin receptors and Ncadherins with NMII isoforms NM-IIA and NMII-B correlate with increased cell-cell adhesion and reduced migratory behavior of the parental Hs578T cells of the Hs578T/Hs578Ts(i)8 triple-negative breast cancer progression model. Using blebbistatin, a …


Development Of A High Performance Liquid Chromatography Method For The Analysis Of Next-Generation Cyanide Antidote, 3-Mercaptopyruvate, In Plasma, Elaf Alzhrani Jan 2018

Development Of A High Performance Liquid Chromatography Method For The Analysis Of Next-Generation Cyanide Antidote, 3-Mercaptopyruvate, In Plasma, Elaf Alzhrani

Electronic Theses and Dissertations

Although the current FDA approved cyanide antidotes (i.e., sodium nitrite, sodium thiosulfate, and hydoxocoboalamine) are effective for treating cyanide poisoning, each individual antidote has major limitations, including large effective dosage, delayed onset of action, or dependence on enzymes generally confined to specific organs. To overcome these current limitations, next-generation cyanide antidotes are being investigated, including 3-mercaptopyruvate (3-MP). Analytical methods capable of detecting 3-MP from plasma are essential for the development of 3-MP as a nextgeneration cyanide antidote. Although 3-MP has been analyzed by LC-MS-MS, this instrument is not widely available. Therefore, a high performance liquid chromatography (HPLC) method with fluorescence …


Land Use Change Sustainability And Carbon Turnover Rate In The Northern Great Plains Soil, Deepak Raj Joshi Jan 2018

Land Use Change Sustainability And Carbon Turnover Rate In The Northern Great Plains Soil, Deepak Raj Joshi

Electronic Theses and Dissertations

Sustainable land management involves the management of land, water, biodiversity and other resources that meet human requirements while maintaining ecosystem services. In the northern Great Plains (NGP), the combined impacts of landuse and climate variability have placed many soils at the tipping point of sustainability. The objectives of this study were to: 1) calculate land-use changes from 2006 to 2012 and from 2012 to 2014 in South Dakota and Nebraska; 2) assess if land use changes had impacted on soil sustainability; 3) calculate variation in total carbon budget and turnover due to seasonal climate variability, biomass quality and soil properties; …


Walleye Fishery Ecology In Lake Oahe Of The Dakotas, Eli Felts Jan 2018

Walleye Fishery Ecology In Lake Oahe Of The Dakotas, Eli Felts

Electronic Theses and Dissertations

Walleye Sander vitreus is among the most popular sport fishes in North America and is the most sought-after fish in both South Dakota and North Dakota. Lake Oahe, a large main stem Missouri River reservoir, spans state boundaries and provides one of the most popular and productive Walleye fisheries in both Dakotas. The Walleye population of Lake Oahe has experienced wide fluctuations in abundance and size structure over the last 25 years which has caused high variability in angler use and satisfaction. Much of this variation is thought to be driven by Rainbow Smelt Osmserus mordax, which are the dominant …


Molecular Level Encapsulation Of Chromophores Using Pillar[5]Arenes For Enhanced Photostability, Manik Gudimani Jan 2018

Molecular Level Encapsulation Of Chromophores Using Pillar[5]Arenes For Enhanced Photostability, Manik Gudimani

Electronic Theses and Dissertations

Organic π-conjugated materials have been researched extensively for a number of applications including organic photovoltaics, electrooptic (EO) modulation, solid-state lasing, organic light emitting diodes (OLEDs), biological imaging and sensing, chemical sensing and ligands for photocatalysts. These organic optoelectronic materials have one major issue that affects its performance and lifetime—photostability. For some applications, hermetical packaging, which is expensive, is required to prevent degradation by light and oxygen. Photooxidation occurs when a material is exposed to light and causes structural and chemical changes leading to photodegradation of the material. The two primary degradation mechanisms responsible for photooxidation involve superoxide radical anion and …


Fast Isotope Ratio Mass Spectrometry (Firms): A Tandem Mass Spectrometry Technique For The Rapid And Semi-Comprehensive Evaluation Of Isotope Ratios, Fredrick Ochieng Jan 2018

Fast Isotope Ratio Mass Spectrometry (Firms): A Tandem Mass Spectrometry Technique For The Rapid And Semi-Comprehensive Evaluation Of Isotope Ratios, Fredrick Ochieng

Electronic Theses and Dissertations

Isotope ratios (IRs) are a measure of the variation in abundance of light isotopes versus heavy isotopes of an element, e.g. 1H/2H,12C/13C, and 14N/15N. Because IRs change as a molecule undergoes certain chemical and physical processes, they represent unique fingerprints that can be used to trace the source of a chemical compound. Current techniques for determination of IRs each have major limitations, such as loss of structural information, vulnerability to contamination, high cost, large sample size requirements, low precision, limited applicability, and lengthy analysis. Fast Isotope Ratio Mass Spectrometry (FIRMS) …


The Impact Of Data Sovereignty On American Indian Self-Determination: A Framework Proof Of Concept Using Data Science, Joseph Carver Robertson Jan 2018

The Impact Of Data Sovereignty On American Indian Self-Determination: A Framework Proof Of Concept Using Data Science, Joseph Carver Robertson

Electronic Theses and Dissertations

The Data Sovereignty Initiative is a collection of ideas that was designed to create SMART solutions for tribal communities. This concept was to develop a horizontal governance framework to create a strategic act of sovereignty using data science. The core concept of this idea was to present data sovereignty as a way for tribal communities to take ownership of data in order to affect policy and strategic decisions that are data driven in nature. The case studies in this manuscript were developed around statistical theories of spatial statistics, exploratory data analysis, and machine learning. And although these case studies are …


Modeling Water Availability, Risk And Resilience In A Semi-Arid Basin In Southern Africa, Esther N. Mosase Jan 2018

Modeling Water Availability, Risk And Resilience In A Semi-Arid Basin In Southern Africa, Esther N. Mosase

Electronic Theses and Dissertations

Climate variability need to be incorporated into the management and planning of water resources, particularly in arid and semi-arid regions, where water availability is more sensitive to rainfall and air temperature. This study used modified Man-Kendall trend analysis test and ArcGIS to process data. Annual means of rainfall, minimum temperature and maximum temperature in the Limpopo River Basin (LRB) varied between 160 and 1109 mm, 8 °C to 20 °C and 23 °C to 32 °C respectively. The spatial pattern is generally increasing from west to east for rainfall and minimum temperature while maximum temperature increases from south to north …


Greenhouse Gas Emissions From Soil Applied Nitrogen Fertilizers, Samuel Thies Jan 2018

Greenhouse Gas Emissions From Soil Applied Nitrogen Fertilizers, Samuel Thies

Electronic Theses and Dissertations

Greenhouse gases (GHG) absorb and emit radiant energy in the thermal range. Their concentrations in the atmosphere are increasing and becoming an ever increasing issue as the Earth’s average temperature continues to rise. Agricultural practices, such as applying nitrogen fertilizer to increase crop yield can be a major source of GHG emissions and methods are needed to decrease these emissions. The measurements of GHG emissions have been difficult, expensive, and erratic. However, advancing technologies have increased the accuracy and confidence in measuring GHG emissions. The objectives of this study were to determine the 1) effects of different nitrogen fertilizer sources, …


Development Of Biclustering Techniques For Gene Expression Data Modeling And Mining, Juan Xie Jan 2018

Development Of Biclustering Techniques For Gene Expression Data Modeling And Mining, Juan Xie

Electronic Theses and Dissertations

The next-generation sequencing technologies can generate large-scale biological data with higher resolution, better accuracy, and lower technical variation than the arraybased counterparts. RNA sequencing (RNA-Seq) can generate genome-scale gene expression data in biological samples at a given moment, facilitating a better understanding of cell functions at genetic and cellular levels. The abundance of gene expression datasets provides an opportunity to identify genes with similar expression patterns across multiple conditions, i.e., co-expression gene modules (CEMs). Genomescale identification of CEMs can be modeled and solved by biclustering, a twodimensional data mining technique that allows clustering of rows and columns in a gene …