Physical Sciences and Mathematics Commons^™

Improving Failure Mode & Effect Analysis ( Fmea ) Method Using Discrete Event Simulation, Adil Abdukeyum

Theses and Dissertations

To improve system performances and process dependability, analyzing the system accurately is an essential step but difficult to achieve and it is even more challenging if the system is complex and dynamic. A popular tool called FMEA has been widely used to analyze and improve systems. However, both academia and industry acknowledge its subjectivity and lack of cause-effect analysis capability. Therefore, in this research, the author presents a more objective and data-driven method called Discrete Event Simulation to improve FMEA’s analysis capability. Also, how the Discrete Event Simulation may enhance the FMEA by a step-by-step analysis approach is presented by …

Towards Constructing Vertex Algebroids, Nicholas J. Klecki

Theses and Dissertations

The notion of vertex algebroids were introduced in the late 1990's as a crucial tool for the study of chiral differential operators and chiral de Rham complex. Vertex algebroids play vital role in the study of N-graded vertex algebra. Also, they have deep connection with representation theory of Leibniz algebras. However, the classification of irreducible modules of vertex algebroids is not completed.

The aim of this thesis is to investigate the possibility of using the simple Lie algebra G_2 and its irreducible modules to construct vertex A-algebroids B that contain G_2 as their Levi factor. Under very mild and natural …

Lie Groups And Euler-Bernoulli Beam Equation, Medeu Amangeldi

Theses and Dissertations

Lie groups approach in differential equations was a breakthrough subject in the late nineteenth century. Sophus Lie, a Norwegian mathematician, introduced the systematic approach to study the solutions of differential equations. The main goal of this thesis is to study, using Lie's approach, the Euler-Bernoulli beam equation subject to swelling force, the fourth-order nonlinear differential equation used to describe the beam deflection under the swelling force. In particular, we will classify the symmetry groups of this equation, obtain several reductions, and demonstrate both analytical and numerical solutions.

Embedding Factorizations, Anna Johnsen

Theses and Dissertations

Let $V$ be a set of $n$ vertices for some $n\in\mathbb{N}$ and let $E$ be a collection of $h$-subsets of $V$. Then $\mathscr G = (V,E)$ is an $h$-unifrom hypergraph and we refer to $V$ as its vertex set and to $E$ as its edge set. We say that $\mathscr G$ is complete and denote it by $K_n^h$ if every $h$-subset of $V$ is contained in $E$. If every edge in $E$ is repeated $\lambda$ times, we say $G$ is $\lambda$-fold. Specifically, $\lambda K_n^h$ is the complete $\lambda$-fold $n$-vertex $h$-uniform hypergraph with an edge set containing $\lambda$ copies of every …

A Computational Investigation Of The Biophysical Mechanisms Underlying Thermotaxis In The Afd Neurons Of Caenorhabditis Elegans, Zachary Mobille

Theses and Dissertations

Thermotaxis in the nematode Caenorhabditis elegans (C. elegans) is studied at the cellular scale of the amphid finger-like ciliated (AFD) neurons, which have previously been shown to be essential for thermoreception. The voltage and calcium signals of AFD during temperature stimuli are described with ordinary differential equations. The primary calcium model is a modified version of that published by Kuramochi and Doi in 2017 to explain the calcium responses of the chemosensitive amphid single-ciliated right (ASER) neuron to fluctuations in extracellular salt concentration. To account for the effects of temperature, changes to the stimuli conditions under which inactivation takes place …

Synthesis Of Oxyquinoliziniporphyrins And Pyridoquinoliziniporphyrins, Emma Cramer

Theses and Dissertations

N-confused porphyrins are porphyrin analogues that introduce a nitrogen outside of the macrocyclic cavity. Two novel N-confused type porphyrins were targeted for this study. Both syntheses use the key intermediate 4-quinolizone. Previous studies of N-confused pyriporphyrin showed that the system is nonaromatic and resembles structurally analogous benziporphyrins. However, modifications to systems of this type can introduce aromatic characteristics. The first system targeted introduced a quinolizone subunit into a porphyrin system. Quinolizone contains a thermodynamically stable amide and this unit disrupts the aromatic pathway. However, dipolar resonance contributors can potentially reinstate some aromatic character. A quinolizone dialdehyde was condensed with tripyrranes …

The Reemergence Of Eradicated Disease Due To Ecological Impact Of Climate Change, Claudia Kolakowski

Theses and Dissertations

Global warming is radically changing aspects of the Earth. As scientists continue to research the effects, the ramifications of melting permafrost is coming to light. We build off of a previously existing Anthrax model in the hopes to include climate change as a factor in Anthrax spread. Chapter II develops a simplified version of an Anthrax model. Parameters for the model are found by using previous research and eigenvalues are analyzed in order to find thresholds and equilibria. Chapter III consider the general solutions of the model through eigenvalues and eigenvectors. This model is then extended to include a parameter …

Barriers And Drivers Influencing The Growth Of E-Commerce In Uzbekistan, Madinakhon Tursunboeva

Theses and Dissertations

Electronic commerce (e-commerce) has become a major retail channel for businesses in developed countries. However, it is still considered an innovation in developing countries. Specifically, e-commerce in Uzbekistan is in the early stages of emergence despite its advance in recent years in terms of Internet penetration, a strong retail sector, new national regulations, and a young population. The study aimed to identify barriers and drivers influencing e-commerce growth in Uzbekistan. A Delphi research design was utilized to answer the research questions of the study, which categorized and ranked factors that Uzbekistani entrepreneurs are facing when engaging in e-commerce processes. A …

Impacts Of Land-Use Change On The Menominee River In Jo Daviess County, Illinois, Preston J. Konop

Theses and Dissertations

This study addresses land-use changes in Jo Daviess County, Illinois, and their effects on the Menominee River. The Menominee River flows north to south through Jo Daviess County, and southern Grant County, Wisconsin. Many of the surrounding properties are agricultural and have undergone developmental and land-use changes that may affect the flood flashiness of the Menominee River. The concern with increasing flood flashiness of the Menominee River include more frequent flooding events, undercutting of riverbanks, and increased amounts of sediment transport from upstream locations into the Mississippi River. Increases in impermeable surfaces have led to greater amounts of runoff during …

Privacy And The Digital Divide: Investigating Strategies For Digital Safety By People Of Color, Denavious Hoover

Theses and Dissertations

People of color are becoming increasingly concerned with digital privacy. They are concerned about the obfuscated data collection and sharing practices of major social media plat- forms and the strong entitlement of other users in the online space to their content. This study examines how people of color conceptualize and behave to produce safety in the online space, or, in other words, digital privacy. This study challenges notions that people are not purposeful about privacy in the online space and highlights the voices of people of color, whom are not of- ten included in theorizing or decision making about the …

Aqueous Kinetics Of Α-Hydroxyhippuric Acid Derivatives Bearing Electron-Withdrawing Groups As A Function Of Ph And Buffer Catalysts, Mohamad Imad Rafie

Theses and Dissertations

It has been shown that carbinolamides are intermediates in the enzyme-catalyzed synthesis of -amidated peptides. Although carbinolamides are important intermediates in the production of these hormones and have roles in other biological venues, little attention has been given to their mechanisms of reaction in water, and, thus, it is difficult to speculate how their reaction would be enzymatically catalyzed. The purpose of the work presented here was to synthesize structural analogs of the biological intermediates and study their mechanism of breakdown in water. -Hydroxyhippuric acid, a substrate for the enzymatic system, provides an easily modified template for the study of …

The Development Of A New Entry Point Into Enantiomerically Enriched Sulfinyl Derivatives, Jessica Shaw

Theses and Dissertations

Optical probes may be used as reliable tools for detecting and imagining the inside of cells for medical diagnostics. Among available options, the use of thiol probes is of interest as thiols are present in nearly all cells and their levels are tightly regulated, thus any variation is associated with disease. A proper thiol bioimaging probe must have a thiol cleavage group/reactive group and a fluorophore. It is found that novel sulfinate aryl ester (phenoxysulfinate esters) probes selectively cleave thiols at physiological pH and show much promise as effective tools for bioimaging.

In this context, the synthesis of the related …

An Investigation Of Gene Regulatory Network State Space Variability, Sara Faye Liesman

Theses and Dissertations

Genes are segments of DNA that provide a blueprint for cells and organisms to effectively control processes and regulations within individuals. There have been many attempts to quantify these processes, as a greater understanding of how genes operate could have large impacts on both personalized and precision medicine. Gene interactions are of particular interest, however, current biological methods can not easily reveal the details of these interactions. Therefore, we infer networks of interactions from gene expression data which we call a gene regulatory network, or GRN. Due to the robust behavior of genes and the inherent variability within interactions, models …

A Study Of The Efficacy Of Machine Learning For Diagnosing Obstructive Coronary Artery Disease In Non-Diabetic Patients, Demond Larae Handley

Theses and Dissertations

According to the Centers for Disease Control and Prevention, about 18.2 million adults age 20 and older have Coronary Artery Disease in the United States. Early diagnosis is therefore of crucial importance to help prevent debilitating consequences, and principally death for many patients. In this study we use data containing gene expression values from peripheral blood samples in 198 non-diabetic patients, with the goal of developing an age and sex gene expression model for diagnosis of Coronary Artery Disease. We employ machine learning methods to obtain a classification based on genetic information, age and sex. Our implementation uses feed forward …

Perceptions Of A Small Midwestern Food Cooperative: A Case Study, Rebecca Forsythe

Theses and Dissertations

The purpose of this research is to illuminate how individuals form perceptions of cooperatives, specifically of Green Top Grocery, a cooperative located in Bloomington Illinois, using the Bourdieu-sian habitus and notions of capital as a frame. Green Top Grocery suffers from fiscal instability since they opened in 2017. They also struggle to gain support of lower income individuals, a key demographic they sought to help since their inception based on their stated values. By conducting qualitative interviews of three sample groups: Green Top Grocery board members and leadership, local food access experts, and West Bloomington residents, and non-participant observations, this …

Rapid Vertical Flow Assay On Aunp Plasmonic Paper For Sers-Based Point Of Need Diagnostics, Richard Frimpong

Theses and Dissertations

SERS based immunoassays for point-of-care diagnostics is a promising tool to facilitate biomarker detection for early disease diagnosis and control. The technique is based on a sandwiched system in which antigen is first captured by a selective substrate and then labeled by an extrinsic Raman label (ERL). Here, we report on the use of gold nanoparticle modified filter paper as a novel capture membrane in a vertical flow format. This vertical flow configuration affords reproducible flow of sample and label through the capture substrate to overcome diffusion limited kinetics and significantly reduced assay time. The filter paper was selected due …

Adsorption Behavior Of Chemically / Charged Modified Antibodies On Gold Nanoparticles, Samuel Okyem

Theses and Dissertations

Gold nanoparticles (AuNPs) have been exploited in the various domains of science such as drug delivery, bio-sensing, immunoassays and environmental sensors, due to their optical properties and intriguing surface chemistry. Different scientific procedures have been used to effectively immobilize antibodies onto AuNPs. Although acceptable outcomes have been achieved in the immobilization of antibodies onto AuNPs, the sensitivity of these immobilized antibodies to target antigen or binding sites is limited due to improper orientation of the antibodies. Also, the possibility of nanoparticle aggregation when exposed to proteins limits its biomedical applicability.

There is some evidence that the surface charge of antibodies …

Investigating The Reversibility Of Protein Adsorption On Gold Nanoparticles And The Role Of Free Thiol, Awosiji Olatunde Awotunde

Theses and Dissertations

Protein-gold nanoparticle (AuNP) bioconjugates have many potential applications in nanomedicine. A thorough understanding of the interaction between the protein and AuNP is critical to engineering these functional bioconjugates with desirable properties. In this work, we investigate the role of free thiols presented by the protein on the stability of the protein-AuNP conjugate. Human serum albumin (HSA) was modified with 2-iminothiolane (Traut’s reagent) to introduce additional thiols on the protein surface, and three variants of HSA were synthesized to present 1, 5, and 20 free thiols by controlling the molar excess of the chemical modifier. Protein exchange studies on AuNPs were …

Oxadiazinones As Chiral Auxiliaries: Chiral Templates For Asymmetric Conjugate Addition In The Synthesis Of ( R )-( + )-Tolterodine, Fatima Olayemi Obe

Theses and Dissertations

The stereoselective formation of carbon-carbon bonds through the process of conjugate addition has proven to be a very important methodology in synthetic organic chemistry. In this context, oxadiazinones are chiral auxiliaries that have been applied in the asymmetric aldol addition reaction to synthesize valuable synthetic fragments such as the aldol side chain of the multi-drug resistance medicinal agent, hapalosin. This thesis describes efforts that were directed towards employing oxadiazinones as chiral scaffolds for the process of asymmetric conjugate addition with the ultimate objective of using this methodology in the preparation of medicinal agents such as Tolterodine. Preliminary efforts focused on …

Nitrate Transport In The Unsaturated Zone, Patience Bosompemaa

Theses and Dissertations

Abundance of nitrate in the soil is a basic issue in agricultural land-use regions, causing eutrophication and pollution of water bodies. The study focuses on the role of a saturated buffer zone (SBZ) to remove nitrate from the groundwater resulting from agricultural activities. The study area is herbaceous SBZ located in central Illinois (40.614382ºN, -89.023542ºW), which lies between a stream and a farm located upgradient. The SBZ has been outfitted with an agricultural runoff treatment system that diverts tile drainage into the subsurface of the SBZ rather than discharging into the stream. Within the SBZ three experimental areas composed of …

Reliability Improvement On Feasibility Study For Selection Of Infrastructure Projects Using Data Mining And Machine Learning, Xi Hu

Theses and Dissertations

With the progressive development of infrastructure construction, conventional analytical methods such as correlation index, quantifying factors, and peer review are no longer satisfactory in support for decision-making of implementing an infrastructure project in the age of big data. This study proposes using a mathematical model named Fuzzy-Neural Comprehensive Evaluation Model (FNCEM) to improve the reliability of the feasibility study of infrastructure projects by using data mining and machine learning. Specifically, the data collection on time-series data, including traffic videos (278 Gigabytes) and historical weather data, uses transportation cameras and online searching, respectively. Meanwhile, the researcher sent out a questionnaire for …

The Role Of Floating Gardens To Alter The Water Quality Of The Chicago River: Chicago, Il, Emmett Andrew Spooner

Theses and Dissertations

The pollution of heavy metals within surface water is a rising global concern. As heavy metals are transported through rivers, they can bioaccumulate through the food web, leading to harmful concentrations within waterways. In urban areas such as the city of Chicago, Illinois, the use of road salts is a concern as elevated concentrations of chloride (Cl–) can reduce surface water quality. Since surface waters can carry heavy metals and Cl– salts over a large distance, methods of in-situ phytoremediation are of growing importance. Through a pilot project, a floating garden system has been installed along a portion of the …

The Water Is Always Running: Vaporwave, Fluxus, And The Role Of Defamiliarization In Music-Led Virtual Realities, Zachary William Buckley

Theses and Dissertations

This thesis examines how a Fluxus approach to participatory music can leverage environmental metaphors and affordances, heighten user awareness of their interactions through a making-strange approach to musical interaction, and balance functional and creative user experiences in a meaningful and participatory musical interaction. This research has been conducted using the virtual reality experience The Water Is Always Running. This work presents an unusual music-making environment, a 3D kitchen with dishwashing simulation, to explore how a making-strange approach to musical interaction and participation can heighten the awareness of process for the user. To create this work, ideas have been leveraged from …

Spatiotemporal Analysis Of Lake Water Quality Indicators On Small Lakes, Lake Bloomington And Evergreen Lake In Central Illinois, Using Satellite Remote Sensing, Gare Ambrose-Igho

Theses and Dissertations

This research explores the use of Sentinel-2 satellite to determine the spatiotemporal patterns of lake water quality indicators (e.g. chlorophyll a) in Lake Bloomington and Evergreen Lake. Lake water quality issues related to algal blooms is a serious problem in basins with abundant agricultural lands causing harmful effects to freshwater ecosystems such as pollution of beaches, taste and odor problems in drinking water, depletion of oxygen levels causing fish kills and the issue of water exceeding safe drinking water standards. Developing monitoring techniques using various water quality indicators of algal blooms is crucial. In this project, remote sensing and field …

Syntheses, Characterization, And Preliminary Evaluation Of Potential Ruthenium Anticancer Complexes Containing Schiff Base Ligands, Stephen Mensah

Theses and Dissertations

Platinum-based drugs have over the years been administered in the treatment of tumours.

Unfortunately, platinum resistance and the severe side effects associated with the treatments has necessitated the research for new anti-cancer drugs. Ruthenium(II) and Ruthenium(III) complexes have shown promise as useful alternative anticancer agents. The lead candidates include the Ru(II) complex RAPTA-C, a ruthenium(II)-arene complex [Ru(η6-p-cymene)Cl2(1,3,5-triaza-7-phosphaadamantane)] and the Ru(III) complex NAMI-A [imidazoleH][trans-Ru(imidazole) (dimethyl sulfoxide)Cl4]. Both compounds have shown potent cytotoxic activity in several primary human tumor models. Unfortunately, NAMI-A could not advance in clinical evaluations due to limited efficacy in vivo, while the clinical evaluation of RAPTA-C is unknown. …

Potential For On-Site, Prosecutorial Evidence From Drug Residues Collected On Plasmonic Paper: A Pilot Study For Sers-Psi-Ms, Daniel S. Burr

Theses and Dissertations

Given the potential impact of improvements to on-site drug testing, as well as recent, successful displays of paper spray ionization mass spectrometry (PSI-MS) in this regard, this thesis pilots the implementation of Raman spectroscopy as a compliment to MS for field-based confirmatory drug testing. Surface enhanced Raman scattering (SERS) is utilized for applications to trace detection. Two-tiered analysis of individual drug samples is enabled using triangularly-cut plasmonic papers, from which both SERS and PS-MS analysis may be performed. Several drug compounds, representative of traditional and emerging drug types, are examined by these techniques, both separately and as a fully integrated, …

Using Satellite-Based Hydro-Climate Variables And Machine Learning For Streamflow Modeling At Various Scales In The Upper Mississippi River Basin, Dongjae Kwon

Theses and Dissertations

Streamflow data are essential to study the hydrologic cycle and to attain appropriate water resource management policies. However, the availability of gauge data is limited due to various reasons such as economic, political, instrumental malfunctioning, and poor spatial distribution. Although streamflow can be simulated by process-based and machine learning approaches, applicability is limited due to intensive modeling effort, or its black-box nature, respectively. Here, we introduce a machine learning (Boosted Regression Tree (BRT)) approach based on remote sensing data to simulate monthly streamflow for three of varying sizes watersheds in the Upper Mississippi River Basin (UMRB). By integrating spatial land …

Chloride Signature And Transport In An Urban-Agricultural Watershed, Andrew Oberhelman

Theses and Dissertations

Manual and high frequency observations (n = 535) of chloride (Cl-), bromide (Br-), nitrate (NO3-N), sodium (Na+), calcium (Ca2+), and potassium (K+) of stream and tile-drain waters were conducted in an urban-agricultural watershed (8% urban, 87% agriculture) to investigate the importance of stormflow to Cl- transport and to explore potential differences in the signature of Cl- originating from an urban source as compared to an agricultural source. The study was conducted in Evergreen Lake Watershed (ELW) located in central Illinois. Manual samplings were conducted on a weekly interval from February 2018 to February 2019 at three station along Six Mile …

Capture Zone Analysis Of A Wellfield To Assess Contaminant Transport, Prince Kojo Oware

Theses and Dissertations

Radium is a common contaminant to the deep Cambrian- Ordovician aquifer in northern Illinois. Deep groundwater aquifers are used as fresh water resource in many parts of the world. Due to overuse, increase in salinity, natural and human-driven contamination, sustainability of these aquifer systems is uncertain. The purpose of this study is to better understand the groundwater flow system in deep bedrock aquifers in northern Illinois, and its control on the radium contamination in Rochelle’s Public Water Supply Wells (PWSW). We have tested two hypotheses: (1) the Radium (Ra) transport is driven by large pumping centers that interrupt groundwater flow …

Hydrogeologic Characteristics And Groundwater Sustainability Of A Deep Bedrock Aquifer System In Illinois, Luis Martinez

Theses and Dissertations

Population growth and climate change has made groundwater an increasingly important freshwater resource. This study uses MODFLOW to estimate sustainable yield of a deep St. Peter Aquifer in Bloomington, IL. The city of Bloomington has installed two high capacity wells into the St. Peter Sandstone to meet its growing water demands. The St. Peter Aquifer is confined, receiving almost no modern recharge and is experiencing overexploitation in parts of Northern Illinois. I hypothesize that existing fast depletion of the deep St. Peter occurs due to lower-than-expected aquifer parameters of the aquifer. Further, current pumping of groundwater from the St. Peter, …