Physical Sciences and Mathematics Commons^™

Molecular Docking Study Of Itpa Protein Substrate Complex, Aulane F. Mpouli

2020 McNair Scholar Collection

ITPA is an enzyme that is responsible for maintaining a proper level of nonstandard nucleotides in cells. The enzyme is associated with adverse drug reactions for thiopurine or ribavirin therapy. The prediction of drug interactions sites in ITPA protein is important for modulating ITPA-related drug toxicity. There are a vast number of tools available to predict molecular interactions between receptors and ligands. The methods utilized in this study include computational docking to explore bound conformation and energy in the binding of ITP to ITPA protein. The docking results reveal how well ITPA and ITP bind together in comparison to the …

Heavy Metals In Particulate Matter In Spokane County, Delaney M. White

2020 Symposium Posters

Heavy metals in particulate matter (e.g., dust) have multiple negative health ramifications for humans including cancer, infertility, and reduced lung function. The Spokane Regional Clean Air Agency (SRCAA) has seven air quality monitoring stations around Spokane County to measure total levels of PM2.5 (particles with a diameter less than 2.5 micrometers) and PM10 (particles with a diameter less than 10 micrometers). For comparison, the width of a human hair is between 50 and 70 micrometers. The objective of this research is to examine the heavy metal composition of the particulate matter including elements such as lead, copper, and zinc. We …

Chemical Weathering Of Deposits From The 1980 Mount St. Helens Eruption And Its Effect On Stream Water Chemistry, Darlene Gilroy, Dr. Carmen Nezat

2020 Symposium Posters

Chemical weathering is an ongoing natural phenomenon that aids in the breakdown of solid rocks and contributes to the chemistry of natural waters and soils. Therefore, studying chemical weathering in a given area may provide a better understanding of the natural influencers on nearby water chemistry. The eruption of Mount St. Helens (MSH) in 1980 provides a unique opportunity to study the chemical weathering of young rocks which typically weather more rapidly than older rocks.

The aim of the study was to determine the relative resistance of the volcanic rocks from the 1980 MSH eruption to chemical weathering by using …

Experiments To Synthesize Soft-Sedimentary Deformation And Clastic Dikes, Chelsi K. Howard

2020 Symposium Posters

Clastic dikes are intrusions of sediments into layers of other sedimentary strata that are found in various places across eastern Washington. Three notable sites include Burlingame Canyon in Touchet, WA, Tucannon Valley near Starbuck, WA and Campion Park in Spokane, WA. Clastic dikes are thought to be formed by either overburden stress or from seismic activity. In eastern WA, the dikes were formed by large overburden pressure and seismic-like forces caused by cataclysmic floods that washed over eastern WA (known as the Missoula floods). We recreated this environment by layering saturated sand below and on top of kaolinite clay, and …

Impact Of Compactive Effort On Soil Strength Of Glacial Lake Columbia Soils, Alexander M. Navarra, Dwight Hendrickson, Jaremy Shaw

2020 Symposium Posters

Glacial Lake Columbia (GLC) existed from 15,550 (+/- 450) to 13,050 (+/- 650) years ago (Atwater, 1986) as a result of the Okanagan Lobe of the Cordilleran Ice Sheet damming the Columbia River near present-day Grand Coulee Dam. The lake deposited a fine-grained basal layer that had interbeds of coarse Missoula Flood deposits and later lake deposits above. Because these GLC deposits are present around most of the Spokane area, they are important to civil engineering and development. We sampled the basal layer of GLC soils from the Peone Prairie, WA. We performed prerequisite testing before the main experiment, with …

Predicting The Properties Of Materials And Biomolecules With Computer Modeling, Gladys Greene, Yao Houndonougbo

2020 Symposium Posters

Abstract:

The advance of theoretical chemistry methods and the increase in computing power have resulted in the frequent use of computer in chemistry, material science, and biology. Zeolitic imidazole frameworks (ZIFs) are a subclass of MOFs which are materials that are made by coordinating transition metal ions to organic ligands to form porous network structures. We have performed Gibbs ensemble Monte Carlo simulations to study the equilibrium selectivity for an equimolar mixture of CO₂ /CH₄ in ZIF-93 at 298K and for pressures up to 80 bar. The results of the simulations revealed the role of pressure in the …

Characterizing Complexity In A Semiconductor With Optical Feedback From Two Mirrors, Layla M. Abrams

2020 Symposium Posters

Lasers are stable devices with a broad spectrum of applications. They can be perturbed to induce complex dynamics in their output intensity. One interesting regime in semiconductor lasers is that the output intensity of the laser emits a sequence of non-regular optical spikes. This behavior resembles that of neurons. We use a semiconductor laser with optical feedback from two mirrors to characterize the behavior of the laser's power output. The data is then analyzed by transforming the intensity time series into a sequence of patterns or words. By doing this we want to explore how the laser changes its preferred …

Geotechnical Engineering: Particle Size Distribution Of Layered Glacial Lake Columbia And Ice Age Flood Deposits In Latah Valley, Spokane, Wa, Aaron Cleveland, Kassie Allen

2020 Symposium Posters

We collected samples from the Latah Valley in Spokane, WA, of Missoula Flood deposits interbedded with Glacial Lake Columbia Sediments. We conducted tests on these soils according to ASTM standards. We performed Specific Gravity tests according to ASTM D854, and determined particle size distribution for these soils by conducting sieve and hydrometer analyses according to ASTM D422. We then plotted these data to create particle size distribution curves. Specific Gravities for the all of the samples collected range from 2.36 to 2.67. The flood deposits are dominated by coarse sand and gravel and the Glacial Lake Columbia deposits are dominated …

Comparison Of The Tally Numbering System To Traditional Arithmetic Systems In Field Programmable Gate Arrays, Robert Paul Shredow

EWU Masters Thesis Collection

This research explores the use of heterogeneous computing platforms for use in machine learning as well as different neural network architectures. These platforms and architectures can be used to accelerate the complex operations that are required for machine learning, more specifically neural networks. The use of different architectures, implementing different types of numbering and mathematics systems is explored in hopes of accelerating mathematical functions. The heterogeneous computing platform explored in this thesis is a Field Programmable Gate Arrays (FPGA), specifically a SoC/FPGA which is a ARM CPU and a FPGA in the same chip. FPGAs are unique because they are …

Comparison Of Wetland Restoration Techniques In And Around Turnbull National Wildlife Refuge, Cheney, Wa, Jade S. Clinkenbeard

EWU Masters Thesis Collection

Throughout the West, wetlands have been drained or filled in for agricultural or urban uses. Staff at Turnbull National Wildlife Refuge (TNWR) in Cheney work with local landowners to restore wetlands through excavation or flooding techniques. Unfortunately, TNWR staff cannot evaluate the wetlands to determine which technique is most successful. This thesis project compared the macroinvertebrate and plant communities and the limnological features of wetlands restored through excavation and flooding with those of unaltered, reference wetlands on TNWR. I hypothesized that the reference wetlands would hold water longest and would have higher plant diversity and macroinvertebrate diversity and abundance than …

Using Blockchain For Digital Card Game, Raymond A. Swannack

EWU Masters Thesis Collection

In recent years, the popularity of both online card games and blockchain technology have grown exponentially. While combining these two does not immediately seem like an obvious idea, they in fact complement each other nicely. Blockchain allows for players to actually own their cards, in a way that was unheard of in the digital format just a few years ago. It also gives them the freedom to use them in any way they like, just like in real life. In this thesis we will look into how viable this idea really is. We use the Ethereum virtual machine to simulate …

Structural Dynamics Of Inosine Triphosphate Pyrophosphatase (Itpa) Protein And Two Clinically Relevant Mutants: Molecular Dynamics Simulations, Yao Houndonougbo, Bethany Pugh, Kandise Vanwormer, Caitlin April, Nicholas Burgis

Chemistry and Biochemistry Faculty Publications

The inosine triphosphate pyrophosphatase (ITPA) protein is responsible for removing noncanonical purine nucleoside triphosphates from intracellular nucleotide pools. Absence of ITPA results in genomic instability and increased levels of inosine in DNA and RNA. The proline to threonine substitution at position 32 (P32T) affects roughly 15% of the global population and can modulate treatment outcomes for cancer, lupus, and hepatitis C patients. The substitution of arginine with cysteine at position 178 (R178C) is extremely uncommon and has only been reported in a small cohort of early infantile encephalopathy patients suggesting that a functional ITPA protein is required for life in …