Physical Sciences and Mathematics Commons^™

A Mathematical Model Of The Effect Of Aspirin On Blood Clotting, Breeana J. Johng

Scripps Senior Theses

In this paper, we provide a mathematical model of the effect of aspirin on blood clotting. The model tracks the enzyme prostaglandin H synthase and an important blood clotting factor, thromboxane A₂, in the form of thromboxane B₂. Through model analysis, we determine conditions under which the reactions of prostaglandin H synthase are self-sustaining. Lastly, through numerical simulations, we demonstrate that the model accurately captures the steady-state chemical concentrations of interest in blood, both with and without aspirin treatment.